Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences
Ganel L, Chen L, Christ R, Vangipurapu J, Young E, Das I, Kanchi K, Larson D, Regier A, Abel H, Kang CJ, Scott A, Havulinna A, Chiang CWK, Service S, Freimer N, Palotie A, Ripatti S, Kuusisto J, Boehnke M, Laakso M, Locke A, Stitziel NO, Hall IM. Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences. Human Genomics 2021, 15: 34. PMID: 34099068, PMCID: PMC8185936, DOI: 10.1186/s40246-021-00335-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedApoptosis Regulatory ProteinsCell LineageDNA Copy Number VariationsDNA, MitochondrialExome SequencingFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenome, MitochondrialGTP-Binding ProteinsHumansMaleMembrane ProteinsMendelian Randomization AnalysisMiddle AgedPhenotypePolymorphism, Single NucleotideProto-Oncogene Proteins c-mybSequence Analysis, DNAConceptsCell type compositionGenome copy numberBlood-derived DNAMitochondrial genome copy numberCombination of genomesCopy numberBulk DNA sequencingDNA sequencingPolygenic risk scoresNumber of mitochondriaExome sequencing dataRelated traitsSequencing dataMetabolic traitsTraitsCommon variantsLociRare variantsSequencingDNAFinnish individualsMendelian randomization frameworkUK BiobankMetS traitsGenomeAssociation of structural variation with cardiometabolic traits in Finns
Chen L, Abel HJ, Das I, Larson DE, Ganel L, Kanchi KL, Regier AA, Young EP, Kang CJ, Scott AJ, Chiang C, Wang X, Lu S, Christ R, Service SK, Chiang CWK, Havulinna AS, Kuusisto J, Boehnke M, Laakso M, Palotie A, Ripatti S, Freimer NB, Locke AE, Stitziel NO, Hall IM. Association of structural variation with cardiometabolic traits in Finns. American Journal Of Human Genetics 2021, 108: 583-596. PMID: 33798444, PMCID: PMC8059371, DOI: 10.1016/j.ajhg.2021.03.008.Peer-Reviewed Original ResearchMeSH KeywordsAllelesCardiovascular DiseasesCholesterolDNA Copy Number VariationsFemaleFinlandGenome, HumanGenomic Structural VariationGenotypeHigh-Throughput Nucleotide SequencingHumansMaleMitochondrial ProteinsPromoter Regions, GeneticPyruvate Dehydrogenase (Lipoamide)-PhosphatasePyruvic AcidSerum Albumin, HumanConceptsSingle nucleotide variantsCopy number variantsQuantitative traitsGenome-wide significant associationStructural variationsTrait mapping studiesDeep whole-genome sequencing dataGenome structural variationsWhole-genome sequencing dataStrong phenotypic effectsComplex genomic regionsCardiometabolic traitsLow-frequency structural variationsEvolutionary timeGenomic regionsPhenotypic effectsSequencing dataNucleotide variantsGenotype dataGene deletionNumber variantsTraitsGenetic associationCandidate associationsExome sequencing