2018
Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
Kim KY, Tanaka Y, Su J, Cakir B, Xiang Y, Patterson B, Ding J, Jung YW, Kim JH, Hysolli E, Lee H, Dajani R, Kim J, Zhong M, Lee JH, Skalnik D, Lim JM, Sullivan GJ, Wang J, Park IH. Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a. Nature Communications 2018, 9: 2583. PMID: 29968706, PMCID: PMC6030064, DOI: 10.1038/s41467-018-04818-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCCAAT-Enhancer-Binding ProteinsCellular ReprogrammingCellular Reprogramming TechniquesChimeraDNA MethylationEpigenesis, GeneticFemaleFibroblastsGene Knockout TechniquesHEK293 CellsHistone CodeHistone-Lysine N-MethyltransferaseHistonesHumansMaleMesodermMiceMouse Embryonic Stem CellsNeural PlateNuclear ProteinsPrimary Cell CultureRecombinant ProteinsUbiquitin-Protein LigasesConceptsEmbryonic stem cellsUnique epigenetic statesBivalent histone modificationsRecruitment of DNMT1Bivalent histone marksCell typesDNA-binding proteinsSpecialized cell typesStem cellsPluripotent stem cellsTrithorax groupBivalent domainsMesoderm specificationCOMPASS complexHeterochromatin formationEpigenetic stateCell specificationHistone marksLineage specificationHistone modificationsEpigenetic regulationSpecific lineagesDNA methylationTranscriptional marksEpigenetic changes
2017
Genetic and Epigenetic Considerations in iPSC Technology
Tanaka Y, Park I. Genetic and Epigenetic Considerations in iPSC Technology. 2017, 51-86. DOI: 10.1201/b21629-3.Peer-Reviewed Original ResearchInduced pluripotent stem cell reprogrammingMethylation patternsN-terminal tail domainsHigher-order structure of chromatinInduced pluripotent stem cellsSomatic cellsDNA methylation patternsStructure of chromatinDeoxyribonucleic acidEfficiency of iPSC generationPosttranslational modificationsEpigenetic modificationsHistone octamerDNA wrappingEpigenetic changesHigher-order structureSomatic reprogrammingEpigenetic modulationEpigenetic considerationsReprogrammingHistonePluripotent statePluripotent stem cellsIPSC generationOriginal somatic cells