2022
Pressure‐based estimation of right ventricular ejection fraction
Heerdt PM, Singh I, Elassal A, Kheyfets V, Richter MJ, Tello K. Pressure‐based estimation of right ventricular ejection fraction. ESC Heart Failure 2022, 9: 1436-1443. PMID: 35150211, PMCID: PMC8934966, DOI: 10.1002/ehf2.13839.Peer-Reviewed Original ResearchConceptsRight ventricular ejection fractionCardiac magnetic resonance imagingRight heart catheterizationPulmonary arterial hypertensionMagnetic resonance imagingRV pressure waveformsVentricular ejection fractionRV responseEjection fractionMale PAH patientsCardiac MRI measurementsReceiver operator characteristic curvePressure waveformROC curve analysisClinical reference standardOperator characteristic curveSignificant reductionMeasurements of RVEFPAH patientsArterial hypertensionHeart catheterizationSecondary outcomesStudy cohortLimits of agreementBland-Altman analysis
2021
Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension
Elassal A, Steppan J, Charania S, Santhanam L, Singh I, Heerdt PM. Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension. Journal Of Pharmacological And Toxicological Methods 2021, 112: 107102. PMID: 34245885, PMCID: PMC8616781, DOI: 10.1016/j.vascn.2021.107102.Peer-Reviewed Original ResearchConceptsRight ventricular ejection fractionPulmonary arterial hypertensionRV pressure waveformsVentricular ejection fractionEjection fractionDepressed right ventricular ejection fractionClear prognostic significanceRight ventricular pressurePressure waveformVolume measurementsPAH therapyPulmonary hypertensionArterial hypertensionPrognostic significanceBland-Altman analysisVentricular pressureRat modelRV volumesRodent modelsDrug effectsHypertensionDrug developmentBeat intervalsRatsRelevant targetsSex-Related Differences in Dynamic Right Ventricular-Pulmonary Vascular Coupling in Heart Failure With Preserved Ejection Fraction
Singh I, Oliveira RKF, Heerdt PM, Pari R, Systrom DM, Waxman AB. Sex-Related Differences in Dynamic Right Ventricular-Pulmonary Vascular Coupling in Heart Failure With Preserved Ejection Fraction. CHEST Journal 2021, 159: 2402-2416. PMID: 33388286, DOI: 10.1016/j.chest.2020.12.028.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiac CatheterizationEchocardiographyExercise ToleranceFemaleFollow-Up StudiesHeart FailureHeart VentriclesHumansIncidenceMalePulmonary ArteryPulmonary Wedge PressureRetrospective StudiesSex DistributionSex FactorsStroke VolumeSystoleUnited StatesVascular ResistanceVentricular Function, RightVentricular PressureConceptsRV-PA couplingRV-PA uncouplingFemale patientsMale patientsPeak VORV contractilityEjection fractionHeart failureRight ventricular-pulmonary vascular couplingRV-pulmonary arterial couplingAge-matched control subjectsInvasive pulmonary hemodynamicsMaximum incremental exercisePulmonary arterial elastanceRV pressure waveformsPeak exercise capacityRight ventricular dysfunctionSingle-beat analysisEnd-systolic elastanceSex-related differencesPA elastanceRV afterloadVentricular dysfunctionAfterload mismatchContractile impairment
2019
A pressure-based single beat method for estimation of right ventricular ejection fraction: proof of concept
Heerdt PM, Kheyfets V, Charania S, Elassal A, Singh I. A pressure-based single beat method for estimation of right ventricular ejection fraction: proof of concept. European Respiratory Journal 2019, 55: 1901635. PMID: 31771999, PMCID: PMC7885179, DOI: 10.1183/13993003.01635-2019.Peer-Reviewed Original ResearchConceptsSingle-beat methodEjection fractionEnd-systolic ventricular elastanceRight ventricular ejection fractionRV pressure waveformsRight ventricular contractilityVentricular ejection fractionRV ejection fractionEes/EaVentricular contractilityCardiovascular decompensationVentricular elastancePressure waveformRight Ventricular-Arterial Uncoupling During Exercise in Heart Failure With Preserved Ejection Fraction Role of Pulmonary Vascular Dysfunction
Singh I, Rahaghi FN, Naeije R, Oliveira RKF, Systrom DM, Waxman AB. Right Ventricular-Arterial Uncoupling During Exercise in Heart Failure With Preserved Ejection Fraction Role of Pulmonary Vascular Dysfunction. CHEST Journal 2019, 156: 933-943. PMID: 31103695, DOI: 10.1016/j.chest.2019.04.109.Peer-Reviewed Original ResearchConceptsEes/EaRV-PA uncouplingPulmonary vascular dysfunctionResistive afterloadHeart failureVascular dysfunctionRight ventricular-pulmonary artery couplingLower pulmonary artery complianceRight ventricular-arterial uncouplingInvasive pulmonary hemodynamicsPulmonary arterial elastanceRV contractile reserveRV pressure waveformsVentricular-arterial uncouplingRight ventricular dysfunctionExercise-induced decreasePulmonary artery complianceExercise-induced increaseGroup of patientsLower peak VOLower stroke volumePeak oxygen consumptionSingle-beat analysisEnd-systolic elastancePVR response