Featured Publications
Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis
Barmada A, Klein J, Ramaswamy A, Brodsky N, Jaycox J, Sheikha H, Jones K, Habet V, Campbell M, Sumida T, Kontorovich A, Bogunovic D, Oliveira C, Steele J, Hall E, Pena-Hernandez M, Monteiro V, Lucas C, Ring A, Omer S, Iwasaki A, Yildirim I, Lucas C. Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis. Science Immunology 2023, 8: eadh3455-eadh3455. PMID: 37146127, PMCID: PMC10468758, DOI: 10.1126/sciimmunol.adh3455.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsContrast MediaCOVID-19COVID-19 VaccinesCytokinesGadoliniumHumansKiller Cells, NaturalLeukocytes, MononuclearMyocarditisSARS-CoV-2ConceptsMRNA vaccinesSARS-CoV-2 mRNA vaccinesSARS-CoV-2 mRNA vaccinationC-reactive protein levelsB-type natriuretic peptidePeripheral blood mononuclear cellsCardiac tissue inflammationDeep immune profilingSerum soluble CD163Vaccine-associated myocarditisCohort of patientsBlood mononuclear cellsCytotoxic T cellsLate gadolinium enhancementHypersensitivity myocarditisElevated troponinMRNA vaccinationImaging abnormalitiesNK cellsImmune profilingKiller cellsMyeloid responseNatriuretic peptideHumoral mechanismsInflammatory cytokines
2007
Role of Procalcitonin and CRP in Differentiating a Stable From a Deteriorating Clinical Course in Pediatric Febrile Neutropenia
Secmeer G, Devrim I, Kara A, Ceyhan M, Cengiz B, Kutluk T, Buyukpamukcu M, Yetgin S, Tuncer M, Uludag AK, Tezer H, Yildirim I. Role of Procalcitonin and CRP in Differentiating a Stable From a Deteriorating Clinical Course in Pediatric Febrile Neutropenia. Journal Of Pediatric Hematology/Oncology 2007, 29: 107-111. PMID: 17279007, DOI: 10.1097/mph.0b013e3180320b5b.Peer-Reviewed Original ResearchConceptsNeutropenic fever patientsC-reactive proteinIntensive chemotherapyNeutropenic feverPCT concentrationsErythrocyte sedimentation rate levelsHacettepe University Ihsan Doğramaci Children's HospitalHours of onsetRole of procalcitoninValue of procalcitoninErythrocyte sedimentation ratePediatric febrile neutropeniaFebrile neutropeniaInflammation parametersControl patientsCRP levelsFebrile episodesOccult infectionUnderlying diseaseAntibiotic therapyClinical courseChildren's HospitalProspective studyTherapy modificationLeukocyte count