2024
Development and comparison of immunologic assays to detect primary RSV infections in infants
Anderson L, Jadhao S, Hussaini L, Ha B, McCracken C, Gibson T, Yildirim I, Yi J, Stephens K, Korski C, Kao C, Sun H, Lee C, Jaunarajs A, Rostad C, Anderson E. Development and comparison of immunologic assays to detect primary RSV infections in infants. Frontiers In Immunology 2024, 14: 1332772. PMID: 38283339, PMCID: PMC10811012, DOI: 10.3389/fimmu.2023.1332772.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusIgG enzyme immunoassayNeutralizing antibody assaysELISPOT assayAntibody assayRSV antibodiesEnzyme immunoassayRSV infectionSubgroup ARespiratory syncytial virus seasonDocumented RSV infectionPrimary RSV infectionEffective respiratory syncytial virusVaccine clinical trialsEvidence of past infectionEpidemiological studiesRed cell lysisYoung childrenMaternal microchimerismPBMC specimensPregnant womenIFN-gSyncytial virusAntibody enzyme immunoassayELISPOT
2021
Respiratory Syncytial Virus–Associated Mortality Among Young Infants in Karachi, Pakistan: A Prospective Postmortem Surveillance Study
Kazi AM, Aguolu OG, Mughis W, Ahsan N, Jamal S, Khan A, Qureshi HM, Yildirim I, Malik FA, Omer SB. Respiratory Syncytial Virus–Associated Mortality Among Young Infants in Karachi, Pakistan: A Prospective Postmortem Surveillance Study. Clinical Infectious Diseases 2021, 73: s203-s209. PMID: 34472574, PMCID: PMC8411247, DOI: 10.1093/cid/ciab488.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusRespiratory symptomsInfant deathRSV seasonalityRole of RSVYoung infantsPresence of RSVMultivariable logistic regression analysisMaternal immunization strategiesSignificant mortality burdenVaccine-hesitant populationYoung infant deathsMultivariable logistic regressionCold-like symptomsSignificant predictorsLogistic regression analysisPostneonatal ageRSV mortalityRSV seasonMaternal immunizationInfant morbidityNasopharyngeal specimensNasopharyngeal swabsSyncytial virusRespiratory illness
2019
2314. Burden of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Older Adults and Those with Underlying Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF)
Anderson E, Hussaini L, Bristow L, Tippett A, Gibson T, Hart M, Salazar L, Gaffney M, Benyeogor I, Cheng A, Drobeniuc A, Traenkner J, Fayad D, Washington W, Emerson L, Schwartz N, Greaves K, Todd S, Stanley C, Bechnak A, Chaaya R, Al-Husien Z, Deović R, Winston J, Ahmed D, Li W, Le K, Singh A, Spencer J, Muchinsky A, Zaks K, Nesheim W, Stephens K, Swerdlow D, Hubler R, Agosti Y, Munye M, Jadhao S, Ha B, McCracken C, Kraft C, Rostad C, Kao C, Lopman B, Yildirim I, Anderson L, Rouphael N, Rouphael N. 2314. Burden of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Older Adults and Those with Underlying Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF). Open Forum Infectious Diseases 2019, 6: s793-s794. PMCID: PMC6810302, DOI: 10.1093/ofid/ofz360.1992.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseCongestive heart failureAcute respiratory infectionsRespiratory viral panelYears of ageHealthy controlsRespiratory syncytial virus infectionOlder adultsRSV antibody titersSyncytial virus infectionObstructive pulmonary diseaseRespiratory syncytial virusFour-fold riseConvalescent serologyClinical characteristicsHeart failurePulmonary diseaseRespiratory infectionsAsymptomatic adultsEligible adultsProspective surveillanceSyncytial virusViral panelAntibody titersOropharyngeal swabs
2018
2354. Performance of Novel Clinical Case Definitions for Respiratory Syncytial Virus Infections in Young Infants: A Latent Class Analysis
Lalani K, Yildirim I, Phadke V, Bednarczyk R, Omer S. 2354. Performance of Novel Clinical Case Definitions for Respiratory Syncytial Virus Infections in Young Infants: A Latent Class Analysis. Open Forum Infectious Diseases 2018, 5: s700-s701. PMCID: PMC6255342, DOI: 10.1093/ofid/ofy210.2007.Peer-Reviewed Original ResearchRespiratory syncytial virusLaboratory-confirmed RSV infectionAcute respiratory infectionsCase definitionNegative predictive valueWorld Health OrganizationRSV infectionNovel RSV therapeuticsRoutine clinical careLatent class analysisHigh-resource settingsAppropriate case definitionsMonths of ageRSV therapeuticsRespiratory infectionsClinical featuresPediatric morbiditySyncytial virusDisease burdenClinical careChild healthcarePredictive valueYoung infantsMajor causeHealth Organization