Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function
Li Z, Kabir I, Tietelman G, Huan C, Fan J, Worgall T, Jiang XC. Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function. Cell Death & Disease 2018, 9: 173. PMID: 29415989, PMCID: PMC5833386, DOI: 10.1038/s41419-017-0214-1.Peer-Reviewed Original ResearchConceptsTamoxifen treatmentBarrier functionInflammatory bowel diseaseGoblet cell numbersCell survivalConcurrent diarrheaSPTLC2 expressionIntestinal cell survivalRectal bleedingBowel diseaseRate-limiting enzymeBody weightColon specimensGoblet cellsSerine palmitoyltransferaseSmall intestineDay 6MiceEarly lifeIntestineReduced lethalitySPT activityCell numberSPTLC2Survival