2018
Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function
Li Z, Kabir I, Tietelman G, Huan C, Fan J, Worgall T, Jiang XC. Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function. Cell Death & Disease 2018, 9: 173. PMID: 29415989, PMCID: PMC5833386, DOI: 10.1038/s41419-017-0214-1.Peer-Reviewed Original ResearchConceptsTamoxifen treatmentBarrier functionInflammatory bowel diseaseGoblet cell numbersCell survivalConcurrent diarrheaSPTLC2 expressionIntestinal cell survivalRectal bleedingBowel diseaseRate-limiting enzymeBody weightColon specimensGoblet cellsSerine palmitoyltransferaseSmall intestineDay 6MiceEarly lifeIntestineReduced lethalitySPT activityCell numberSPTLC2Survival
2016
Small Intestine but Not Liver Lysophosphatidylcholine Acyltransferase 3 (Lpcat3) Deficiency Has a Dominant Effect on Plasma Lipid Metabolism*
Kabir I, Li Z, Bui HH, Kuo MS, Gao G, Jiang XC. Small Intestine but Not Liver Lysophosphatidylcholine Acyltransferase 3 (Lpcat3) Deficiency Has a Dominant Effect on Plasma Lipid Metabolism*. Journal Of Biological Chemistry 2016, 291: 7651-7660. PMID: 26828064, PMCID: PMC4817191, DOI: 10.1074/jbc.m115.697011.Peer-Reviewed Original ResearchMeSH Keywords1-Acylglycerophosphocholine O-AcyltransferaseAnimalsATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 8ATP-Binding Cassette TransportersCD36 AntigensCell MembraneEnterocytesIntestine, SmallLipid MetabolismLipoproteinsLiverMembrane Transport ProteinsMiceMice, KnockoutOrgan SpecificityConceptsLpcat3 deficiencySmall intestineLipid levelsSignificant lipid accumulationLipid metabolismLiver deficiencyLipid accumulationPlasma lipid levelsPlasma lipid metabolismCassette transporter 1Plasma triglyceride levelsNiemann-Pick C1Lysophosphatidylcholine acyltransferase 3ABCG8 levelsCholesterol secretionTriglyceride levelsPlasma triglyceridesBody weightLipid absorptionPhospholipid levelsDay 9Transporter 1IntestineLiverEnterocyte plasma membrane
2015
All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity[S]
Ding T, Kabir I, Li Y, Lou C, Yazdanyar A, Xu J, Dong J, Zhou H, Park T, Boutjdir M, Li Z, Jiang XC. All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity[S]. Journal Of Lipid Research 2015, 56: 537-545. PMID: 25605874, PMCID: PMC4340302, DOI: 10.1194/jlr.m054627.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsMiceMice, KnockoutSphingomyelinsTransferases (Other Substituted Phosphate Groups)ConceptsCeramide phosphoethanolamineCPE levelsSynthase activityObvious phenotypic alterationsSynthase gene familySf9 insect cellsQuantitative MS analysisGene familyCeramide homeostasisInsect cellsCritical regulatorNBD-ceramideSMS2 activityPhenotypic alterationsSMS1SMS1 deficiencySphingolipid levelsSMS2Ceramide levelsCell functionKO miceCell studiesMS analysisFamily membersCells