Liver serine palmitoyltransferase activity deficiency in early life impairs adherens junctions and promotes tumorigenesis
Li Z, Kabir I, Jiang H, Zhou H, Libien J, Zeng J, Stanek A, Ou P, Li KR, Zhang S, Bui HH, Kuo M, Park T, Kim B, Worgall TS, Huan C, Jiang X. Liver serine palmitoyltransferase activity deficiency in early life impairs adherens junctions and promotes tumorigenesis. Hepatology 2016, 64: 2089-2102. PMID: 27642075, PMCID: PMC5115983, DOI: 10.1002/hep.28845.Peer-Reviewed Original ResearchConceptsAdherens junctionsSerine palmitoyltransferaseHepatocyte polaritySubunit 2 geneCanonical Wnt pathwaySphingolipid biosynthesisPlasma membraneKey enzymeMajor proteinsWnt pathwayRecombination approachHepatocyte plasma membraneCellular distributionΒ-cateninTumorigenesisCadherin phosphorylationSphingomyelin levelsActivity deficiencyCentral componentPalmitoyltransferaseMembraneCadherinBiosynthesisLiver regenerationGenes