Small Intestine but Not Liver Lysophosphatidylcholine Acyltransferase 3 (Lpcat3) Deficiency Has a Dominant Effect on Plasma Lipid Metabolism*
Kabir I, Li Z, Bui HH, Kuo MS, Gao G, Jiang XC. Small Intestine but Not Liver Lysophosphatidylcholine Acyltransferase 3 (Lpcat3) Deficiency Has a Dominant Effect on Plasma Lipid Metabolism*. Journal Of Biological Chemistry 2016, 291: 7651-7660. PMID: 26828064, PMCID: PMC4817191, DOI: 10.1074/jbc.m115.697011.Peer-Reviewed Original ResearchMeSH Keywords1-Acylglycerophosphocholine O-AcyltransferaseAnimalsATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 8ATP-Binding Cassette TransportersCD36 AntigensCell MembraneEnterocytesIntestine, SmallLipid MetabolismLipoproteinsLiverMembrane Transport ProteinsMiceMice, KnockoutOrgan SpecificityConceptsLpcat3 deficiencySmall intestineLipid levelsSignificant lipid accumulationLipid metabolismLiver deficiencyLipid accumulationPlasma lipid levelsPlasma lipid metabolismCassette transporter 1Plasma triglyceride levelsNiemann-Pick C1Lysophosphatidylcholine acyltransferase 3ABCG8 levelsCholesterol secretionTriglyceride levelsPlasma triglyceridesBody weightLipid absorptionPhospholipid levelsDay 9Transporter 1IntestineLiverEnterocyte plasma membrane