2024
Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons
Wu J, Quraishi I, Zhang Y, Bromwich M, Kaczmarek L. Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons. Cell Reports 2024, 43: 113904. PMID: 38457342, PMCID: PMC11013952, DOI: 10.1016/j.celrep.2024.113904.Peer-Reviewed Original ResearchInhibitory neuronsRegulation of neuronal excitabilityPotassium channel mutationsVoltage-dependent sodiumInhibitory cortical neuronsGain-of-function mutationsAxon initial segmentKCNT1 geneNeuronal excitabilityChannel subunitsChannel mutationsNetwork hyperexcitabilityMouse modelNeuron typesCortical neuronsTreat epilepsyNeuronsExcitable neuronsNeurological disordersSevere intellectual disabilityMutationsInitial segmentKCNT1ExpressionHyperexcitability
2020
Responsive Neurostimulation
Gummadavelli A, Quraishi I, Gerrard J. Responsive Neurostimulation. 2020, 145-173. DOI: 10.1007/978-3-030-34906-6_12.ChaptersResponsive neurostimulationRefractory epilepsyIntracranial EEG activityUse of neurostimulationSurgical implantation techniqueChronic electrophysiological recordingsSeizure progressionTherapeutic approachesNeurological disordersElectrophysiological recordingsNeurostimulationDisease statesEEG activityNetwork synchronyEpilepsyImplantation techniquePathology