2013
Liver Fatty Acid-Binding Protein (L-Fabp) Modifies Intestinal Fatty Acid Composition and Adenoma Formation in ApcMin/+ Mice
Dharmarajan S, Newberry EP, Montenegro G, Nalbantoglu I, Davis VR, Clanahan MJ, Blanc V, Xie Y, Luo J, Fleshman JW, Kennedy S, Davidson NO. Liver Fatty Acid-Binding Protein (L-Fabp) Modifies Intestinal Fatty Acid Composition and Adenoma Formation in ApcMin/+ Mice. Cancer Prevention Research 2013, 6: 1026-1037. PMID: 23921281, PMCID: PMC3791217, DOI: 10.1158/1940-6207.capr-13-0120.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaAnimalsCell ProliferationDietary FatsDinoprostoneFatty Acid-Binding ProteinsFatty AcidsFemaleGene DeletionGene Expression Regulation, NeoplasticGenotypeImmunohistochemistryIntestinal MucosaLipidsMiceMice, TransgenicPolymerase Chain ReactionRNA, MessengerSignal TransductionTime FactorsConceptsFatty acid traffickingDietary fat intakeFatty acid speciesFatty acid-binding proteinAcid-binding proteinFatty acid metabolismFat intakeIntestinal fatty acid metabolismIntestinal tumorigenesisCellular proliferationAcid metabolismFatty acid elongationNuclear hormone receptorsΒ-catenin translocationNuclear β-catenin translocationDiet-induced obesityHigh-grade dysplasiaLiver fatty acid-binding proteinIntestinal fatty acid-binding proteinIntestinal tumor formationImportant genetic modifiersSignificant reductionAcid speciesMetabolic compartmentalizationGenetic modifiersIntestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer
Xie Y, Matsumoto H, Nalbantoglu I, Kerr TA, Luo J, Rubin DC, Kennedy S, Davidson NO. Intestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer. PLOS ONE 2013, 8: e67819. PMID: 23805328, PMCID: PMC3689718, DOI: 10.1371/journal.pone.0067819.Peer-Reviewed Original ResearchConceptsMttp-IKO miceDextran sodium sulfateDSS treatmentExperimental colitisTumor burdenColitis-Associated CancerDevelopment of colitisIndependent risk factorDietary fat intakeColonic mRNA expressionLevels of TNFαColonic tumor burdenIntestine-specific deletionMicrosomal triglyceride transfer proteinDSS administrationColonic inflammationColonic injuryIL-17AInflammasome expressionSystemic injuryFat intakeFat malabsorptionColorectal cancerCytokine expressionIL-1β
2009
Tumor Regression following DNA Vaccination and Regulatory T Cell Depletion in neu Transgenic Mice Leads to an Increased Risk for Autoimmunity
Jacob JB, Kong YC, Nalbantoglu I, Snower DP, Wei WZ. Tumor Regression following DNA Vaccination and Regulatory T Cell Depletion in neu Transgenic Mice Leads to an Increased Risk for Autoimmunity. The Journal Of Immunology 2009, 182: 5873-5881. PMID: 19380836, PMCID: PMC3833444, DOI: 10.4049/jimmunol.0804074.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCancer VaccinesCell Line, TumorFemaleGenetic Predisposition to DiseaseLymphocyte DepletionMammary Neoplasms, ExperimentalMiceMice, Inbred BALB CMice, TransgenicNIH 3T3 CellsRatsReceptor, ErbB-2Remission InductionThyroglobulinThyroiditis, AutoimmuneT-Lymphocytes, RegulatoryVaccines, DNAConceptsRegulatory T-cell depletionT-cell depletionDNA vaccinationTumor regressionTreg depletionCell depletionBALB/c miceAnti-tumor immunityNeu transgenic miceAutoimmune manifestationsImmunotherapeutic regimensAutoimmune thyroiditisTolerant miceMouse thyroglobulinTumor immunityCD25 mAbComplete regressionImmune reactivityAutoimmune diseasesC miceCancer immunotherapyCancer patientsClinical trialsFemale miceLong-term protection