2020
Recurrent Autoimmune Hepatitis and De Novo Autoimmune Hepatitis in the Liver Allograft
González IA, Hartley CP, Nalbantoglu I. Recurrent Autoimmune Hepatitis and De Novo Autoimmune Hepatitis in the Liver Allograft. American Journal Of Clinical Pathology 2020, 155: 435-445. PMID: 33252121, DOI: 10.1093/ajcp/aqaa147.Peer-Reviewed Original ResearchConceptsDe novo AIHOrthotopic liver transplantDe novo autoimmune hepatitisAutoimmune hepatitisNovo autoimmune hepatitisRecurrent AIHRecurrent autoimmune hepatitisGraft survivalPresentation of AIHModerate portal inflammationOverall graft survivalAggressive clinical courseSubmassive necrosisLiver allograftsLiver transplantPortal inflammationSevere hepatitisAggressive treatmentAdvanced fibrosisClinical courseClinicopathologic characteristicsFemale predominanceSevere inflammationHepatitisPatients
2018
Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm
Joseph NM, Brunt EM, Marginean C, Nalbantoglu I, Snover DC, Thung SN, Yeh MM, Umetsu SE, Ferrell LD, Gill RM. Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm. The American Journal Of Surgical Pathology 2018, 42: 1201-1207. PMID: 29975248, DOI: 10.1097/pas.0000000000001110.Peer-Reviewed Original ResearchConceptsHepatic small vessel neoplasmVariant lesionsGNA14 mutationsVascular neoplasmLow-grade vascular neoplasmLow-grade neoplasmsVascular lesionsCavernous hemangiomaInfiltrative natureCytologic atypiaMolecular pathogenesisNeoplasmsPanel sequencingCopy number alterationsHotspot mutationsExome sequencingLesionsPathogenic mutationsSmall vesselsGNAQSame missense mutationNumber alterationsLiverMissense mutationsMutations
2017
Differentiation of Hepatocellular Carcinoma from Other Hepatic Malignancies in Patients at Risk: Diagnostic Performance of the Liver Imaging Reporting and Data System Version 2014.
Fraum TJ, Tsai R, Rohe E, Ludwig DR, Salter A, Nalbantoglu I, Heiken JP, Fowler KJ. Differentiation of Hepatocellular Carcinoma from Other Hepatic Malignancies in Patients at Risk: Diagnostic Performance of the Liver Imaging Reporting and Data System Version 2014. Radiology 2017, 286: 158-172. PMID: 28853673, DOI: 10.1148/radiol.2017170114.Peer-Reviewed Original ResearchConceptsNon-HCC malignanciesArterial phase hyperenhancementRim arterial phase hyperenhancementPositive predictive valueHepatocellular carcinomaPredictive valueData System (LI-RADS) version 2014Diagnostic performancePopulation of patientsHIPAA-compliant institutional review boardLiver Imaging ReportingLR-5 criteriaMalignant liver massesLI-RADS categoryFisher's exact testInstitutional review boardClinical followExtrahepatic malignanciesPathology findingsCommon findingLiver massExact testIndependent sample t-testMalignancyImaging ReportingHow does it feel to be a pathology resident? Results of a survey on experiences and job satisfaction during pathology residency
Pehlivanoglu B, Hassoy H, Calle C, Dendooven A, Nalbantoglu I, Reshchikova L, Gul G, Doganavsargil B. How does it feel to be a pathology resident? Results of a survey on experiences and job satisfaction during pathology residency. Virchows Archiv 2017, 471: 413-422. PMID: 28624995, DOI: 10.1007/s00428-017-2167-2.Peer-Reviewed Original ResearchConceptsHealth care systemPatient managementClinicians/surgeonsPathology residencyCountry's health care systemCommon reasonGross examinationMedical teamExperienced pathologistsTraining programResidency training programsPathologyCare systemMolecular pathologyPathologistsResidency program directorsPhysical working conditionsWeb-based linkMost respondentsPathology traineesTumor budding in intestinal-type gastric adenocarcinoma is associated with nodal metastasis and recurrence
Olsen S, Jin L, Fields RC, Yan Y, Nalbantoglu I. Tumor budding in intestinal-type gastric adenocarcinoma is associated with nodal metastasis and recurrence. Human Pathology 2017, 68: 26-33. PMID: 28428104, DOI: 10.1016/j.humpath.2017.03.021.Peer-Reviewed Original ResearchConceptsIntestinal-type gastric adenocarcinomaHigher T stageIntestinal-type cancerGastric adenocarcinomaT stageNodal metastasisN stageLymph node statusSubset of patientsPrimary surgical excisionAmount of tumorCancer-related deathLikelihood of recurrenceDiffuse cancersBetter prognosisHistologic typePrognostic featuresSurgical excisionTumor buddingTumor characteristicsNode statusIntestinal tumorsClinical managementColorectal adenocarcinomaTumor grade
2016
Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that Serve Mesenteric Lymph Nodes in Crohn Disease
Randolph GJ, Bala S, Rahier JF, Johnson MW, Wang PL, Nalbantoglu I, Dubuquoy L, Chau A, Pariente B, Kartheuser A, Zinselmeyer BH, Colombel JF. Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that Serve Mesenteric Lymph Nodes in Crohn Disease. American Journal Of Pathology 2016, 186: 3066-3073. PMID: 27746181, PMCID: PMC5225286, DOI: 10.1016/j.ajpath.2016.07.026.Peer-Reviewed Original ResearchConceptsTertiary lymphoid organsMesenteric lymph nodesLymph nodesCrohn's diseaseLymphatic collecting vesselsInfection-induced tissue damageInnate lymphoid cellsChronic inflammatory stateImmune cell accessHuman intestinal diseasesMesenteric adipose tissueEarly pathological descriptionsAppropriate immunityInflammatory stateLymphoid organsPoor healingIntestinal diseaseLymphoid cellsPathological descriptionAdipose tissueB cellsAnatomical relationshipTissue damageCD specimensLymphatic remodelingCharacterization of Colorectal Cancer Development in Apcmin/+ Mice
Nalbantoglu I, Blanc V, Davidson NO. Characterization of Colorectal Cancer Development in Apcmin/+ Mice. Methods In Molecular Biology 2016, 1422: 309-327. PMID: 27246043, PMCID: PMC5061497, DOI: 10.1007/978-1-4939-3603-8_27.ChaptersConceptsDextran sulfate sodiumCancer developmentCommon pathologic lesionsBile acid supplementationExperimental colorectal cancerColorectal cancer developmentHigh-fat dietColon cancer developmentSulfate sodiumColorectal cancerFat dietAcid supplementationPathologic lesionsTherapeutic aspectsIntestinal neoplasiaC57BL/6J backgroundEnvironmental modifiersExperimental modelMiceExcellent experimental modelTissue processingNeoplasiaLesionsCancerGastrointestinal Parasitosis: Histopathological Insights to Rare But Intriguing Lesions of the Gastrointestinal Tract
Pehlivanoğlu B, Doğanavşargil B, Sezak M, Nalbantoğlu İ, Korkmaz M. Gastrointestinal Parasitosis: Histopathological Insights to Rare But Intriguing Lesions of the Gastrointestinal Tract. Turkish Journal Of Pathology 2016, 32: 82-90. PMID: 27136106, DOI: 10.5146/tjpath.2015.01350.Peer-Reviewed Case Reports and Technical NotesConceptsEosinophils/hpfActive mucosal inflammationMild eosinophilic infiltrateMucosal architectural changesIncrease of eosinophilsInflammatory bowel diseasePresence of inflammationTaenia saginata infectionCharcot-Leyden crystalsF. hepaticaBowel obstructionNonspecific inflammationEosinophilic infiltrateEosinophilic infiltrationMucosal inflammationBowel diseaseMucosal changesStool testLymphoid aggregatesDefinitive diagnosisHistopathological insightsBiopsy specimensCeliac diseaseGranuloma formationIntriguing lesionsHepatic small vessel neoplasm, a rare infiltrative vascular neoplasm of uncertain malignant potential
Gill RM, Buelow B, Mather C, Joseph NM, Alves V, Brunt EM, Liu TC, Makhlouf H, Marginean C, Nalbantoglu I, Sempoux C, Snover DC, Thung SN, Yeh MM, Ferrell LD. Hepatic small vessel neoplasm, a rare infiltrative vascular neoplasm of uncertain malignant potential. Human Pathology 2016, 54: 143-151. PMID: 27090685, PMCID: PMC5242228, DOI: 10.1016/j.humpath.2016.03.018.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCell ProliferationClass I Phosphatidylinositol 3-KinasesDiagnosis, DifferentialDNA Mutational AnalysisFemaleGTP-Binding Protein alpha Subunits, Gq-G11Hemangioma, CavernousHemangiosarcomaHumansImmunohistochemistryKi-67 AntigenLiver NeoplasmsMaleMiddle AgedMutationNeoplasm GradingPhosphatidylinositol 3-KinasesPredictive Value of TestsProto-Oncogene Proteins c-mycTerminology as TopicTumor Suppressor Protein p53Vascular NeoplasmsYoung AdultConceptsHepatic small vessel neoplasmMalignant potentialCavernous hemangiomaVascular neoplasmImmunohistochemical stainsProliferative indexKi-67 proliferative indexTumour cell proliferative indexDisseminated intravascular coagulationKasabach-Merritt syndromePossible malignant potentialLow-grade tumorsUncertain malignant potentialRare vascular neoplasmCapture-based next-generation sequencingHistologic differential diagnosisCell proliferative indexC-myc stainingStrong p53Intravascular coagulationComplete resectionHepatic angiosarcomaDifferential diagnosisInfiltrative bordersAngiosarcoma
2015
Outcomes Using Grafts from Donors after Cardiac Death
Doyle MB, Collins K, Vachharajani N, Lowell JA, Shenoy S, Nalbantoglu I, Byrnes K, Garonzik-Wang J, Wellen J, Lin Y, Chapman WC. Outcomes Using Grafts from Donors after Cardiac Death. Journal Of The American College Of Surgeons 2015, 221: 142-152. PMID: 26095563, DOI: 10.1016/j.jamcollsurg.2015.03.053.Peer-Reviewed Original ResearchConceptsIschemic cholangiopathyPrimary nonfunctionRecipient ageLiver transplantationDonor graftsDCD donorsCardiac death liver graftsEnd-stage liver diseaseAdult liver transplantationDCD graft recipientsHepatic artery thrombosisAcute kidney injuryBrain-dead donorsLong-term outcomesWarm ischemia timeCold flushingDCD graftsDCD recipientsMedian ICUArtery thrombosisGraft survivalHospital stayKidney injuryRecipients of donationGraft recipients
2014
Histological features and severity of oxaliplatin‐induced liver injury and clinical associations
Nalbantoglu I, Tan B, Linehan D, Gao F, Brunt E. Histological features and severity of oxaliplatin‐induced liver injury and clinical associations. Journal Of Digestive Diseases 2014, 15: 553-560. PMID: 25060628, DOI: 10.1111/1751-2980.12177.Peer-Reviewed Original ResearchConceptsOxaliplatin-induced liver injuryHigher injury scoresInjury scoreLiver injuryAspartate aminotransferaseElevated preoperative aspartate aminotransferaseShort-term postoperative complicationsSerum liver enzyme levelsColorectal carcinoma liver metastasesAbnormal AST levelsComponent of chemotherapyHepatic sinusoidal injuryPreoperative aspartate aminotransferaseMetastatic colorectal carcinomaLiver enzyme levelsLiver injury scoreBody mass indexLong-term outcomesSinusoidal lining cellsManifestations of injuryLight microscopic lesionsAlkaline phosphatase levelsInjury scoring systemNon-tumor liverLower injury scoresDifferential expression of miR-31 between inflammatory bowel disease and microscopic colitis.
Zhang C, Zhao Z, Osman H, Watson R, Nalbantoglu I, Lin J. Differential expression of miR-31 between inflammatory bowel disease and microscopic colitis. MicroRNA 2014, 3: 155-9. PMID: 25665881, DOI: 10.2174/2211536604666150209115444.Peer-Reviewed Original ResearchConceptsIdiopathic inflammatory bowel diseaseMicroscopic colitisInflammatory bowel diseaseLymphocytic colitisCollagenous colitisMiR-31 expressionBowel diseaseMiR-31Colonic tissueSeparate disease processesMC episodesUlcerative colitisCrohn's diseaseExpression patternsColitisIntermittent episodesNormal controlsDisease processUseful biomarkerDifferential expressionPatientsColon tissuesDistinct entityDiseaseQRT-PCR
2013
Liver Fatty Acid-Binding Protein (L-Fabp) Modifies Intestinal Fatty Acid Composition and Adenoma Formation in ApcMin/+ Mice
Dharmarajan S, Newberry EP, Montenegro G, Nalbantoglu I, Davis VR, Clanahan MJ, Blanc V, Xie Y, Luo J, Fleshman JW, Kennedy S, Davidson NO. Liver Fatty Acid-Binding Protein (L-Fabp) Modifies Intestinal Fatty Acid Composition and Adenoma Formation in ApcMin/+ Mice. Cancer Prevention Research 2013, 6: 1026-1037. PMID: 23921281, PMCID: PMC3791217, DOI: 10.1158/1940-6207.capr-13-0120.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaAnimalsCell ProliferationDietary FatsDinoprostoneFatty Acid-Binding ProteinsFatty AcidsFemaleGene DeletionGene Expression Regulation, NeoplasticGenotypeImmunohistochemistryIntestinal MucosaLipidsMiceMice, TransgenicPolymerase Chain ReactionRNA, MessengerSignal TransductionTime FactorsConceptsFatty acid traffickingDietary fat intakeFatty acid speciesFatty acid-binding proteinAcid-binding proteinFatty acid metabolismFat intakeIntestinal fatty acid metabolismIntestinal tumorigenesisCellular proliferationAcid metabolismFatty acid elongationNuclear hormone receptorsΒ-catenin translocationNuclear β-catenin translocationDiet-induced obesityHigh-grade dysplasiaLiver fatty acid-binding proteinIntestinal fatty acid-binding proteinIntestinal tumor formationImportant genetic modifiersSignificant reductionAcid speciesMetabolic compartmentalizationGenetic modifiers
2012
Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice
Carvalho FA, Koren O, Goodrich JK, Johansson ME, Nalbantoglu I, Aitken JD, Su Y, Chassaing B, Walters WA, González A, Clemente JC, Cullender TC, Barnich N, Darfeuille-Michaud A, Vijay-Kumar M, Knight R, Ley RE, Gewirtz AT. Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice. Cell Host & Microbe 2012, 12: 139-152. PMID: 22863420, PMCID: PMC4310462, DOI: 10.1016/j.chom.2012.07.004.Peer-Reviewed Original ResearchConceptsChronic colitisGenetic influencing factorsTLR5-deficient miceChronic gut inflammationLow-grade inflammationMucosal immune systemInnate immune deficiencyProinflammatory gene expressionWild-type miceContribution of microbiotaTransient high levelsGut inflammationImmune deficiencyIntestinal microbiotaColitisGut microbiotaImmune systemMice displayUnstable microbiotaGut epitheliumTransient inabilityMicrobiotaInflammationBreakdown of homeostasisIncomplete penetrancePositron Emission Tomography with [18F]-3′-Deoxy-3′fluorothymidine (FLT) as a Predictor of Outcome in Patients with Locally Advanced Resectable Rectal Cancer: a Pilot Study
Dehdashti F, Grigsby PW, Myerson RJ, Nalbantoglu I, Ma C, Siegel BA. Positron Emission Tomography with [18F]-3′-Deoxy-3′fluorothymidine (FLT) as a Predictor of Outcome in Patients with Locally Advanced Resectable Rectal Cancer: a Pilot Study. Molecular Imaging And Biology 2012, 15: 106-113. PMID: 22684813, PMCID: PMC3659775, DOI: 10.1007/s11307-012-0566-y.Peer-Reviewed Original ResearchConceptsDisease-free survivalPositron emission tomographyFDG uptakeFLT uptakeRectal cancerAdvanced resectable rectal cancerEmission tomographyImproved disease-free survivalMaximum standardized uptake valuePercentage changePilot studyResectable rectal cancerAdvanced rectal cancerFDG-PET/Predictors of outcomeStandardized uptake valuePurposeThis pilot studyNeoadjuvant chemoradiotherapyProgressive diseaseRegional lymphResultsThirteen patientsFLT-PETHigher percentage changeTumor uptakeUptake value
2009
Tumor Regression following DNA Vaccination and Regulatory T Cell Depletion in neu Transgenic Mice Leads to an Increased Risk for Autoimmunity
Jacob JB, Kong YC, Nalbantoglu I, Snower DP, Wei WZ. Tumor Regression following DNA Vaccination and Regulatory T Cell Depletion in neu Transgenic Mice Leads to an Increased Risk for Autoimmunity. The Journal Of Immunology 2009, 182: 5873-5881. PMID: 19380836, PMCID: PMC3833444, DOI: 10.4049/jimmunol.0804074.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCancer VaccinesCell Line, TumorFemaleGenetic Predisposition to DiseaseLymphocyte DepletionMammary Neoplasms, ExperimentalMiceMice, Inbred BALB CMice, TransgenicNIH 3T3 CellsRatsReceptor, ErbB-2Remission InductionThyroglobulinThyroiditis, AutoimmuneT-Lymphocytes, RegulatoryVaccines, DNAConceptsRegulatory T-cell depletionT-cell depletionDNA vaccinationTumor regressionTreg depletionCell depletionBALB/c miceAnti-tumor immunityNeu transgenic miceAutoimmune manifestationsImmunotherapeutic regimensAutoimmune thyroiditisTolerant miceMouse thyroglobulinTumor immunityCD25 mAbComplete regressionImmune reactivityAutoimmune diseasesC miceCancer immunotherapyCancer patientsClinical trialsFemale miceLong-term protection