2017
Tumor budding in intestinal-type gastric adenocarcinoma is associated with nodal metastasis and recurrence
Olsen S, Jin L, Fields RC, Yan Y, Nalbantoglu I. Tumor budding in intestinal-type gastric adenocarcinoma is associated with nodal metastasis and recurrence. Human Pathology 2017, 68: 26-33. PMID: 28428104, DOI: 10.1016/j.humpath.2017.03.021.Peer-Reviewed Original ResearchConceptsIntestinal-type gastric adenocarcinomaHigher T stageIntestinal-type cancerGastric adenocarcinomaT stageNodal metastasisN stageLymph node statusSubset of patientsPrimary surgical excisionAmount of tumorCancer-related deathLikelihood of recurrenceDiffuse cancersBetter prognosisHistologic typePrognostic featuresSurgical excisionTumor buddingTumor characteristicsNode statusIntestinal tumorsClinical managementColorectal adenocarcinomaTumor grade
2016
Hepatic small vessel neoplasm, a rare infiltrative vascular neoplasm of uncertain malignant potential
Gill RM, Buelow B, Mather C, Joseph NM, Alves V, Brunt EM, Liu TC, Makhlouf H, Marginean C, Nalbantoglu I, Sempoux C, Snover DC, Thung SN, Yeh MM, Ferrell LD. Hepatic small vessel neoplasm, a rare infiltrative vascular neoplasm of uncertain malignant potential. Human Pathology 2016, 54: 143-151. PMID: 27090685, PMCID: PMC5242228, DOI: 10.1016/j.humpath.2016.03.018.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCell ProliferationClass I Phosphatidylinositol 3-KinasesDiagnosis, DifferentialDNA Mutational AnalysisFemaleGTP-Binding Protein alpha Subunits, Gq-G11Hemangioma, CavernousHemangiosarcomaHumansImmunohistochemistryKi-67 AntigenLiver NeoplasmsMaleMiddle AgedMutationNeoplasm GradingPhosphatidylinositol 3-KinasesPredictive Value of TestsProto-Oncogene Proteins c-mycTerminology as TopicTumor Suppressor Protein p53Vascular NeoplasmsYoung AdultConceptsHepatic small vessel neoplasmMalignant potentialCavernous hemangiomaVascular neoplasmImmunohistochemical stainsProliferative indexKi-67 proliferative indexTumour cell proliferative indexDisseminated intravascular coagulationKasabach-Merritt syndromePossible malignant potentialLow-grade tumorsUncertain malignant potentialRare vascular neoplasmCapture-based next-generation sequencingHistologic differential diagnosisCell proliferative indexC-myc stainingStrong p53Intravascular coagulationComplete resectionHepatic angiosarcomaDifferential diagnosisInfiltrative bordersAngiosarcoma
2014
Role of liver biopsy in nonalcoholic fatty liver disease.
Nalbantoglu I, Brunt E. Role of liver biopsy in nonalcoholic fatty liver disease. World Journal Of Gastroenterology 2014, 20: 9026-37. PMID: 25083076, PMCID: PMC4112884, DOI: 10.3748/wjg.v20.i27.9026.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNonalcoholic fatty liver diseaseFatty liver diseaseLiver diseaseLiver biopsyPediatric nonalcoholic fatty liver diseaseNASH Clinical Research NetworkLocation of fibrosisSpecific histologic lesionsCardiovascular risk factorsExcess alcohol intakeChronic liver diseaseClinical Research NetworkClinical research trialsLiver biopsy evaluationLimitations of biopsyNon-invasive testingImportant liver diseaseHepatic manifestationNecroinflammatory activityMetabolic syndromeAlcohol intakeHistologic findingsHepatic triglyceridesRisk factorsBiopsy evaluation
2012
Positron Emission Tomography with [18F]-3′-Deoxy-3′fluorothymidine (FLT) as a Predictor of Outcome in Patients with Locally Advanced Resectable Rectal Cancer: a Pilot Study
Dehdashti F, Grigsby PW, Myerson RJ, Nalbantoglu I, Ma C, Siegel BA. Positron Emission Tomography with [18F]-3′-Deoxy-3′fluorothymidine (FLT) as a Predictor of Outcome in Patients with Locally Advanced Resectable Rectal Cancer: a Pilot Study. Molecular Imaging And Biology 2012, 15: 106-113. PMID: 22684813, PMCID: PMC3659775, DOI: 10.1007/s11307-012-0566-y.Peer-Reviewed Original ResearchConceptsDisease-free survivalPositron emission tomographyFDG uptakeFLT uptakeRectal cancerAdvanced resectable rectal cancerEmission tomographyImproved disease-free survivalMaximum standardized uptake valuePercentage changePilot studyResectable rectal cancerAdvanced rectal cancerFDG-PET/Predictors of outcomeStandardized uptake valuePurposeThis pilot studyNeoadjuvant chemoradiotherapyProgressive diseaseRegional lymphResultsThirteen patientsFLT-PETHigher percentage changeTumor uptakeUptake value