Intestinal Epithelial HuR Modulates Distinct Pathways of Proliferation and Apoptosis and Attenuates Small Intestinal and Colonic Tumor Development
Giammanco A, Blanc V, Montenegro G, Klos C, Xie Y, Kennedy S, Luo J, Chang SH, Hla T, Nalbantoglu I, Dharmarajan S, Davidson NO. Intestinal Epithelial HuR Modulates Distinct Pathways of Proliferation and Apoptosis and Attenuates Small Intestinal and Colonic Tumor Development. Cancer Research 2014, 74: 5322-5335. PMID: 25085247, PMCID: PMC4167566, DOI: 10.1158/0008-5472.can-14-0726.Peer-Reviewed Original ResearchConceptsTumor burdenSmall intestineFecal bile acid excretionAcute intestinal injuryColitis-associated cancerBile acid excretionBile acid metabolismColonic epithelial cellsAOM-DSSIntestinal deletionIntestinal injuryProapoptotic gene expressionIntestinal cancerCarcinogenesis protocolIntestinal expressionAcid excretionASBT expressionIntestinal tumorigenesisIntestinal growthVillus heightTransgenic modelGenetic deletionMiceExpression of transcriptsHuR gene