2016
Characterization of Colorectal Cancer Development in Apcmin/+ Mice
Nalbantoglu I, Blanc V, Davidson NO. Characterization of Colorectal Cancer Development in Apcmin/+ Mice. Methods In Molecular Biology 2016, 1422: 309-327. PMID: 27246043, PMCID: PMC5061497, DOI: 10.1007/978-1-4939-3603-8_27.ChaptersConceptsDextran sulfate sodiumCancer developmentCommon pathologic lesionsBile acid supplementationExperimental colorectal cancerColorectal cancer developmentHigh-fat dietColon cancer developmentSulfate sodiumColorectal cancerFat dietAcid supplementationPathologic lesionsTherapeutic aspectsIntestinal neoplasiaC57BL/6J backgroundEnvironmental modifiersExperimental modelMiceExcellent experimental modelTissue processingNeoplasiaLesionsCancer
2014
Intestinal Epithelial HuR Modulates Distinct Pathways of Proliferation and Apoptosis and Attenuates Small Intestinal and Colonic Tumor Development
Giammanco A, Blanc V, Montenegro G, Klos C, Xie Y, Kennedy S, Luo J, Chang SH, Hla T, Nalbantoglu I, Dharmarajan S, Davidson NO. Intestinal Epithelial HuR Modulates Distinct Pathways of Proliferation and Apoptosis and Attenuates Small Intestinal and Colonic Tumor Development. Cancer Research 2014, 74: 5322-5335. PMID: 25085247, PMCID: PMC4167566, DOI: 10.1158/0008-5472.can-14-0726.Peer-Reviewed Original ResearchConceptsTumor burdenSmall intestineFecal bile acid excretionAcute intestinal injuryColitis-associated cancerBile acid excretionBile acid metabolismColonic epithelial cellsAOM-DSSIntestinal deletionIntestinal injuryProapoptotic gene expressionIntestinal cancerCarcinogenesis protocolIntestinal expressionAcid excretionASBT expressionIntestinal tumorigenesisIntestinal growthVillus heightTransgenic modelGenetic deletionMiceExpression of transcriptsHuR gene
2012
Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges
Carvalho F, Nalbantoglu I, Aitken J, Uchiyama R, Su Y, Doho G, Vijay-Kumar M, Gewirtz A. Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges. Mucosal Immunology 2012, 5: 288-298. PMID: 22318495, PMCID: PMC3328601, DOI: 10.1038/mi.2012.8.Peer-Reviewed Original ResearchConceptsInflammasome activation resultsDevelopment of colitisDextran sulfate sodiumInnate immune activatorsDetection of flagellinIntestinal gene expressionPredispose miceSulfate sodiumEpithelial injuryIL-18IL-1βImmune activatorsIntestinal homeostasisSevere diseaseFlagellin administrationSalmonella infectionMonoclonal antibodiesSystemic challengesMiceNLRC4Transcription-independent pathwayIntestinal genesAdministrationActivation resultsBacterial flagellin
2011
The Expression Of Interferon Receptor Alpha/Beta In Human Pancreatic Cancer In Nude Mice Is Essential For Tumor Response To Interferon Alpha Treatment
Saidi R, Ahad A, Talik J, Nalbantoglu I, Jacobs M. The Expression Of Interferon Receptor Alpha/Beta In Human Pancreatic Cancer In Nude Mice Is Essential For Tumor Response To Interferon Alpha Treatment. Journal Of Surgical Research 2011, 165: 335. DOI: 10.1016/j.jss.2010.11.195.Peer-Reviewed Original Research