2014
Differential expression of miR-31 between inflammatory bowel disease and microscopic colitis.
Zhang C, Zhao Z, Osman H, Watson R, Nalbantoglu I, Lin J. Differential expression of miR-31 between inflammatory bowel disease and microscopic colitis. MicroRNA 2014, 3: 155-9. PMID: 25665881, DOI: 10.2174/2211536604666150209115444.Peer-Reviewed Original ResearchConceptsIdiopathic inflammatory bowel diseaseMicroscopic colitisInflammatory bowel diseaseLymphocytic colitisCollagenous colitisMiR-31 expressionBowel diseaseMiR-31Colonic tissueSeparate disease processesMC episodesUlcerative colitisCrohn's diseaseExpression patternsColitisIntermittent episodesNormal controlsDisease processUseful biomarkerDifferential expressionPatientsColon tissuesDistinct entityDiseaseQRT-PCR
2012
Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice
Carvalho FA, Koren O, Goodrich JK, Johansson ME, Nalbantoglu I, Aitken JD, Su Y, Chassaing B, Walters WA, González A, Clemente JC, Cullender TC, Barnich N, Darfeuille-Michaud A, Vijay-Kumar M, Knight R, Ley RE, Gewirtz AT. Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice. Cell Host & Microbe 2012, 12: 139-152. PMID: 22863420, PMCID: PMC4310462, DOI: 10.1016/j.chom.2012.07.004.Peer-Reviewed Original ResearchConceptsChronic colitisGenetic influencing factorsTLR5-deficient miceChronic gut inflammationLow-grade inflammationMucosal immune systemInnate immune deficiencyProinflammatory gene expressionWild-type miceContribution of microbiotaTransient high levelsGut inflammationImmune deficiencyIntestinal microbiotaColitisGut microbiotaImmune systemMice displayUnstable microbiotaGut epitheliumTransient inabilityMicrobiotaInflammationBreakdown of homeostasisIncomplete penetrance