2024
Generalizable and replicable brain-based predictions of cognitive functioning across common psychiatric illness
Chopra S, Dhamala E, Lawhead C, Ricard J, Orchard E, An L, Chen P, Wulan N, Kumar P, Rubenstein A, Moses J, Chen L, Levi P, Holmes A, Aquino K, Fornito A, Harpaz-Rotem I, Germine L, Baker J, Yeo B, Holmes A. Generalizable and replicable brain-based predictions of cognitive functioning across common psychiatric illness. Science Advances 2024, 10: eadn1862. PMID: 39504381, PMCID: PMC11540040, DOI: 10.1126/sciadv.adn1862.Peer-Reviewed Original ResearchConceptsPrediction of cognitionCognitive functionPrediction of cognitive functionFunctional neuroimaging dataTransdiagnostic sampleComputational psychiatryPsychiatric illnessNeuroimaging dataCognitive impairmentCognitionPopulation-level datasetsPsychiatryAssociated with poor outcomesUK BiobankImpairmentBrainIllnessSymptomsPrediction studiesParticipantsPoor outcomeClinical studiesSamplesPrevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans.
Fischer I, Na P, Harpaz-Rotem I, Marx B, Pietrzak R. Prevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39480145, DOI: 10.4088/jcp.24m15465.Peer-Reviewed Original ResearchConceptsSubthreshold posttraumatic stress disorderPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersLifetime psychiatric disordersUS veteransUS military veteransSymptom-related distressStress disorderPsychiatric disordersSymptom clustersTreating veteransCriterion AMilitary veteransTraumatic eventsCognitive functionWorking case definitionMental healthCriterion FFunctional impairmentVeteransNationally representative sampleFunctional correlatesDisordersElevated oddsGreater oddsAmygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original Research
2023
Firearm Ownership Among a Nationally Representative Sample of U.S. Veterans
Fischer I, Aunon F, Nichter B, Hill M, Panza K, Kline A, Na P, Tsai J, Harpaz-Rotem I, Pietrzak R. Firearm Ownership Among a Nationally Representative Sample of U.S. Veterans. American Journal Of Preventive Medicine 2023, 65: 1129-1133. PMID: 37354925, DOI: 10.1016/j.amepre.2023.06.013.Peer-Reviewed Original ResearchConceptsU.S. veteransMultivariable logistic regression analysisLogistic regression analysisAlcohol use disorderSuicide prevention effortsU.S. military veteransNationally Representative SampleMale sexTrauma burdenNational HealthRepresentative sampleFirearm ownershipChi-square analysisUse disordersFirearm safetyIndependent sample t-testLifetime historyVeterans StudyPrevention effortsPsychiatric variablesMilitary veteransVeteransRegression analysisT-testSignificant main effectNeural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach
Jia R, Ruderman L, Pietrzak R, Gordon C, Ehrlich D, Horvath M, Mirchandani S, DeFontes C, Southwick S, Krystal J, Harpaz-Rotem I, Levy I. Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach. Translational Psychiatry 2023, 13: 101. PMID: 36977676, PMCID: PMC10050320, DOI: 10.1038/s41398-023-02388-4.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderValuation systemStress disorderCombat veteransMaintenance of PTSDSubjective valueBrain valuation systemNeural valuation systemVentromedial prefrontal cortexFunctional MRI studyFunction of symptomsMale combat veteransNeural valuationSeries of choicesFear learningPunishment processingPosttrauma symptomsPTSD symptomsNeural encodingNeural mechanismsUncertain optionsPrefrontal cortexSubjective valuationVentral striatumMonetary gainsUnderstanding veteran barriers to specialty outpatient PTSD clinical care
Rozek D, Steigerwald V, Baker S, Gross G, Maieritsch K, Hoff R, Harpaz-Rotem I, Smith N. Understanding veteran barriers to specialty outpatient PTSD clinical care. Journal Of Anxiety Disorders 2023, 95: 102675. PMID: 36854224, DOI: 10.1016/j.janxdis.2023.102675.Peer-Reviewed Original ResearchConceptsSpecialty outpatient clinicsPosttraumatic stress disorderOutpatient clinicPTSD specialty clinicClinical characteristicsMale sexPTSD symptom severitySpecialty clinicWhite raceClinical careClinical concernTreatment engagementSymptom severityStress disorderClinicGreater likelihoodVeteransSignificant minorityTreatmentImpact of demographicsMulti-faceted barriersCareFiscal year 2019DemographicsNational sampleEvaluating the Evidence for Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma
Ben-Zion Z, Spiller T, Keynan J, Admon R, Levy I, Liberzon I, Shalev A, Hendler T, Harpaz-Rotem I. Evaluating the Evidence for Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma. American Journal Of Psychiatry 2023, 180: 146-154. PMID: 36628514, PMCID: PMC9898083, DOI: 10.1176/appi.ajp.20220271.Peer-Reviewed Original ResearchConceptsPosttraumatic psychopathologyPsychiatric vulnerabilityGeneral hospital emergency departmentHospital emergency departmentRecent trauma survivorsAdditional replication studiesEmergency departmentObjective neural markersDifferent longitudinal patternsProspective symptomsMonths posttraumaAcute aftermathPsychiatric disordersEffective personalized treatmentTrauma exposureFunctional MRIPersonalized treatmentConsistent subgroupTreatment implicationsNeural activityAssessment 1Neural markersLongitudinal studyNeurobiological indicesDiagnostic methods
2022
Delirium screening in an acute care setting with a machine learning classifier based on routinely collected nursing data: A model development study
Spiller TR, Tufan E, Petry H, Böttger S, Fuchs S, Duek O, Ben-Zion Z, Korem N, Harpaz-Rotem I, von Känel R, Ernst J. Delirium screening in an acute care setting with a machine learning classifier based on routinely collected nursing data: A model development study. Journal Of Psychiatric Research 2022, 156: 194-199. PMID: 36252349, DOI: 10.1016/j.jpsychires.2022.10.018.Peer-Reviewed Original ResearchConceptsDelirium Observation ScaleAcute care settingNursing dataCare settingsSingle tertiary teaching hospitalPatients 18 yearsTertiary teaching hospitalDelirium prediction modelSuch screening programsDelirium screeningAcute careMean ageTeaching hospitalInclusion criteriaScreening programDeliriumPatientsClinical practiceTotal scoreDemographic characteristicsCharacteristic curveScreening procedureModel development studiesRiskAdditional measuresA comparison of methods to harmonize cortical thickness measurements across scanners and sites
Sun D, Rakesh G, Haswell CC, Logue M, Baird CL, O'Leary EN, Cotton AS, Xie H, Tamburrino M, Chen T, Dennis EL, Jahanshad N, Salminen LE, Thomopoulos SI, Rashid F, Ching CRK, Koch SBJ, Frijling JL, Nawijn L, van Zuiden M, Zhu X, Suarez-Jimenez B, Sierk A, Walter H, Manthey A, Stevens JS, Fani N, van Rooij SJH, Stein M, Bomyea J, Koerte IK, Choi K, van der Werff SJA, Vermeiren RRJM, Herzog J, Lebois LAM, Baker JT, Olson EA, Straube T, Korgaonkar MS, Andrew E, Zhu Y, Li G, Ipser J, Hudson AR, Peverill M, Sambrook K, Gordon E, Baugh L, Forster G, Simons RM, Simons JS, Magnotta V, Maron-Katz A, du Plessis S, Disner SG, Davenport N, Grupe DW, Nitschke JB, deRoon-Cassini TA, Fitzgerald JM, Krystal JH, Levy I, Olff M, Veltman DJ, Wang L, Neria Y, De Bellis MD, Jovanovic T, Daniels JK, Shenton M, van de Wee NJA, Schmahl C, Kaufman ML, Rosso IM, Sponheim SR, Hofmann DB, Bryant RA, Fercho KA, Stein DJ, Mueller SC, Hosseini B, Phan KL, McLaughlin KA, Davidson RJ, Larson CL, May G, Nelson SM, Abdallah CG, Gomaa H, Etkin A, Seedat S, Harpaz-Rotem I, Liberzon I, van Erp TGM, Quidé Y, Wang X, Thompson PM, Morey RA. A comparison of methods to harmonize cortical thickness measurements across scanners and sites. NeuroImage 2022, 261: 119509. PMID: 35917919, PMCID: PMC9648725, DOI: 10.1016/j.neuroimage.2022.119509.Peer-Reviewed Original ResearchRisk for PTSD symptom worsening during new PTSD treatment episode in a nationally representative sample of treatment-seeking U.S. veterans with subthreshold PTSD
Gross GM, Pietrzak RH, Hoff RA, Katz IR, Harpaz-Rotem I. Risk for PTSD symptom worsening during new PTSD treatment episode in a nationally representative sample of treatment-seeking U.S. veterans with subthreshold PTSD. Journal Of Psychiatric Research 2022, 151: 304-310. PMID: 35526446, DOI: 10.1016/j.jpsychires.2022.04.040.Peer-Reviewed Original ResearchConceptsSymptom worseningRisk factorsSubthreshold PTSDPTSD symptom clustersSymptom clustersPTSD symptomsHealth care utilizationPTSD specialty clinicPoor treatment outcomesUnited States veteransBinary logistic regressionAdjusted analysisCare utilizationTreatment episodesRepresentative sampleSpecialty clinicSignificant symptomsTreatment outcomesSignificant worseningStates veteransSubthreshold symptomsEligible veteransNew episodesOutcome assessmentDiagnostic threshold
2021
Mindfulness as a Mediator Between Trauma Exposure and Mental Health Outcomes: Results From the National Health and Resilience in Veterans Study
Kachadourian LK, Harpaz-Rotem I, Tsai J, Southwick S, Pietrzak RH. Mindfulness as a Mediator Between Trauma Exposure and Mental Health Outcomes: Results From the National Health and Resilience in Veterans Study. Psychological Trauma Theory Research Practice And Policy 2021, 13: 223-230. PMID: 33475404, PMCID: PMC8500672, DOI: 10.1037/tra0000995.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAlcohol use disorderLifetime traumaTrauma-related negative affectPresent momentVeterans StudyU.S. veteransTrauma-related experiencesSuicidal ideationTraumatic life eventsLifetime trauma burdenMental health outcomesQuality of lifeMental health problemsTrauma remindersNegative affectMindful attentionTrauma exposurePTSD symptomsMental health issuesTraumatic eventsCumulative traumaStress disorderNoncombat veteransLife events
2020
Sex Differences in Associations Between Depression and Posttraumatic Stress Disorder Symptoms and Tobacco Use Among Veterans of Recent Conflicts
Gross GM, Bastian LA, Smith NB, Harpaz-Rotem I, Hoff R. Sex Differences in Associations Between Depression and Posttraumatic Stress Disorder Symptoms and Tobacco Use Among Veterans of Recent Conflicts. Journal Of Women's Health 2020, 29: 677-685. PMID: 31934813, DOI: 10.1089/jwh.2019.8082.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderTobacco usePTSD symptomsFemale veteransSex differencesAssociation of depressionTobacco use cessationBaseline interview dataCross-sectional associationsMental health conditionsLogistic regression modelsPosttraumatic stress disorder (PTSD) symptomsBinary logistic regression modelSex-specific barriersTobacco usersSymptomsStress disorderAlcohol useHealth conditionsDepressionDisorder symptomsVeteran sampleMH conditionsIntervention strategiesEffects of demographics
2019
Comparing the effectiveness of VA residential PTSD treatment for veterans who do and do not report a history of MST: A national investigation
Holliday R, Smith NB, Holder N, Gross GM, Monteith LL, Maguen S, Hoff RA, Harpaz-Rotem I. Comparing the effectiveness of VA residential PTSD treatment for veterans who do and do not report a history of MST: A national investigation. Journal Of Psychiatric Research 2019, 122: 42-47. PMID: 31923834, DOI: 10.1016/j.jpsychires.2019.12.012.Peer-Reviewed Original ResearchConceptsResidential Rehabilitation Treatment ProgramMilitary sexual traumaPosttraumatic stress disorderPTSD symptomsMST survivorsPTSD treatmentVeterans AffairsProgram completionRehabilitation treatment programSymptom severity scoresEffects of MSTExperience of MSTHistory of MSTPTSD symptom severity scoresPost-treatment gainsRace/ethnicityImpact of MSTSevere PTSD symptomsResidential PTSD treatmentAdjunctive servicesPsychiatric comorbiditySeverity scoreHealth sequelaeIncrease riskWomen veteransPosttraumatic stress symptom courses in U.S. military veterans: A seven-year, nationally representative, prospective cohort study
Mota NP, Cook JM, Smith NB, Tsai J, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH. Posttraumatic stress symptom courses in U.S. military veterans: A seven-year, nationally representative, prospective cohort study. Journal Of Psychiatric Research 2019, 119: 23-31. PMID: 31546045, DOI: 10.1016/j.jpsychires.2019.09.005.Peer-Reviewed Original ResearchConceptsPTSD symptom courseSymptom courseU.S. military veteransLatent growth mixture modelingProspective cohort studyMilitary veteransLifetime psychiatric historyMental health treatmentPhysical health difficultiesLifetime traumatic eventsTrauma-exposed veteransProtective psychosocial characteristicsCohort studyProspective cohortModerate symptomsModifiable correlatesNational HealthSymptomatic coursePsychiatric historyHealth treatmentU.S. veteransVeterans StudyPsychosocial characteristicsHigher symptomsHealth difficultiesApolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study
Averill LA, Abdallah CG, Levey DF, Han S, Harpaz‐Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2019, 36: 834-845. PMID: 31385647, DOI: 10.1002/da.22912.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderExecutive functionCognitive functioningStress disorderΕ4 carrier statusΕ4 carriersVeterans StudyCognitive dysfunctionAttention/concentrationGreater cognitive difficultiesLower cognitive functioningOlder U.S. veteransΕ4 allele carrier statusPerseverative errorsCognitive difficultiesReplication sampleCarrier statusCognitive functionImportance of assessingNational HealthCognitive declinePredictive effectApolipoprotein E gene polymorphismE gene polymorphismΕ4 allele carriersRandomized Controlled Trial of Imagery Rehearsal for Posttraumatic Nightmares in Combat Veterans.
Harb GC, Cook JM, Phelps AJ, Gehrman PR, Forbes D, Localio R, Harpaz-Rotem I, Gur RC, Ross RJ. Randomized Controlled Trial of Imagery Rehearsal for Posttraumatic Nightmares in Combat Veterans. Journal Of Clinical Sleep Medicine 2019, 15: 757-767. PMID: 31053215, PMCID: PMC6510682, DOI: 10.5664/jcsm.7770.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPosttraumatic stress disorderNightmare Distress QuestionnaireNightmare Frequency QuestionnaireBehavioral therapySevere posttraumatic stress disorderUnited States veteransOperation Enduring Freedom/Operation Iraqi Freedom veteransImagery rehearsalOperation Iraqi Freedom veteransSubgroups of veteransIraqi Freedom veteransFrequency questionnaireControlled TrialsPrimary outcomeLikelihood ratio chi-squareStates veteransDistress QuestionnaireStress disorderChi-squareRecurrent nightmaresConfidence intervalsMilitary veteransVeteransCombat veteransAdoption by VA Residential Programs of Two Evidence-Based Psychotherapies for PTSD: Effect on Patient Outcomes
Cook JM, Schnurr PP, Simiola V, Thompson R, Hoff R, Harpaz-Rotem I. Adoption by VA Residential Programs of Two Evidence-Based Psychotherapies for PTSD: Effect on Patient Outcomes. Psychiatric Services 2019, 70: 553-560. PMID: 30966944, PMCID: PMC6690369, DOI: 10.1176/appi.ps.201800338.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive Behavioral TherapyComorbidityDepressionFemaleHumansImplosive TherapyMaleMiddle AgedOutcome and Process Assessment, Health CarePsychological DistressResidential TreatmentStress Disorders, Post-TraumaticSubstance-Related DisordersUnited StatesUnited States Department of Veterans AffairsVeteransConceptsPosttraumatic stress disorderCognitive processing therapyEvidence-based psychotherapiesVeterans Affairs residential treatment programsAdoption groupsAlcohol useResidential treatment programSample of veteransGroup × time interactionPTSD symptomsStress disorderGroup formatProgram intakeResidential programs× time interactionDepression symptomsTreatment programPsychotherapyBasis of responsesPatient outcomesTime interactionProgram dischargeQualitative interviewsMonths postdischargeVeteransExamining the nonresponse phenomenon: Factors associated with treatment response in a national sample of veterans undergoing residential PTSD treatment
Sripada RK, Blow FC, Rauch SAM, Ganoczy D, Hoff R, Harpaz-Rotem I, Bohnert KM. Examining the nonresponse phenomenon: Factors associated with treatment response in a national sample of veterans undergoing residential PTSD treatment. Journal Of Anxiety Disorders 2019, 63: 18-25. PMID: 30785007, DOI: 10.1016/j.janxdis.2019.02.001.Peer-Reviewed Original ResearchConceptsResidential PTSD treatmentPTSD treatmentPTSD symptom changeTreatment-seeking veteransContextual protective factorsPhysical health resourcesNational sampleLarge national samplePsychological stateIndividual-level factorsLife eventsMultilevel modelingSymptom changeTreatment entryPoor treatment responseProtective factorsWorse treatment responsePersonality disorderPTSDBetter treatment responseTreatment responseCurrent studyGreater pain severityVeteransTheory of resourcesNeural computations of threat in the aftermath of combat trauma
Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Neural computations of threat in the aftermath of combat trauma. Nature Neuroscience 2019, 22: 470-476. PMID: 30664770, PMCID: PMC6829910, DOI: 10.1038/s41593-018-0315-x.Peer-Reviewed Original ResearchConceptsPTSD symptomsPost-traumatic stress disorder symptomsHigher PTSD symptom severityThreat-predictive cuesPTSD symptom severityAssociative threatPredictive cuesNeural trackingDisorder symptomsPrediction errorCombat veteransDynamic learning rateNegative outcomesCombat traumaSmaller amygdala volumesNeural computationLatent markersSymptomatic veteransSymptom severityAmygdala volumeAssociabilityCuesLearning rateVeteransSymptoms
2018
Protective correlates of suicidality among veterans with histories of posttraumatic stress disorder and major depressive disorder: Results from the National Health and Resilience in Veterans Study
Kachadourian LK, Tsai J, Harpaz-Rotem I, Southwick SM, Pietrzak RH. Protective correlates of suicidality among veterans with histories of posttraumatic stress disorder and major depressive disorder: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2018, 246: 731-737. PMID: 30616162, DOI: 10.1016/j.jad.2018.12.058.Peer-Reviewed Original ResearchMeSH KeywordsAdultCross-Sectional StudiesDepressive Disorder, MajorFemaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOptimismPrevalenceProtective FactorsResilience, PsychologicalRisk FactorsStress Disorders, Post-TraumaticSuicidal IdeationSuicideSuicide, AttemptedSurveys and QuestionnairesUnited StatesVeteransYoung AdultConceptsMajor depressive disorderPosttraumatic stress disorderProtective correlatesSuicidal ideationSuicide attemptsProtective factorsDepressive disorderNational HealthVeterans StudyMultivariable logistic regression analysisSuicidal behaviorStress disorderHistory of PTSDLogistic regression analysisSample of veteransAssessment of suicidalityLifetime suicide attemptsRisk factorsHigh-risk sampleTreatment approachesU.S. veteransWeb-based surveyCross-sectional natureSuicide riskSelf-report items