2024
Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original Research
2023
Neural patterns differentiate traumatic from sad autobiographical memories in PTSD
Perl O, Duek O, Kulkarni K, Gordon C, Krystal J, Levy I, Harpaz-Rotem I, Schiller D. Neural patterns differentiate traumatic from sad autobiographical memories in PTSD. Nature Neuroscience 2023, 26: 2226-2236. PMID: 38036701, DOI: 10.1038/s41593-023-01483-5.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderTraumatic memoriesAutobiographical memoryNeural patternsIntersubject representational similarity analysisSimilar neural representationsRepresentational similarity analysisPosterior cingulate cortexTrauma memoriesMnemonic featuresNegative memoriesMultivoxel patternsNeural representationCognitive stateHippocampal representationsCognitive entitiesStress disorderCingulate cortexNeural activityTraumatic narrativesIndividual symptom severitySemantic representationMemory typesOwn memoryMemoryLong term structural and functional neural changes following a single infusion of Ketamine in PTSD
Duek O, Korem N, Li Y, Kelmendi B, Amen S, Gordon C, Milne M, Krystal J, Levy I, Harpaz-Rotem I. Long term structural and functional neural changes following a single infusion of Ketamine in PTSD. Neuropsychopharmacology 2023, 48: 1648-1658. PMID: 37270621, PMCID: PMC10517133, DOI: 10.1038/s41386-023-01606-3.Peer-Reviewed Original ResearchConceptsKetamine recipientsSingle infusionMain study outcomeTiming of administrationEnd of treatmentNMDA receptor antagonistFunctional neural changesFrequency of administrationSignificant clinical implicationsTrauma-focused psychotherapyBrief exposure therapyAmygdala-vmPFC connectivityPost-retrieval extinctionKetamine doseKetamine administrationReceptor antagonistTrauma scriptsNeural changesClinical implicationsDecreased connectivityExposure therapyKetamineTrauma memoriesStudy outcomesUncinate fasciculusUncertainty in learning and decision-making: Introduction to the special issue
Levy I, Schiller D. Uncertainty in learning and decision-making: Introduction to the special issue. Cognitive, Affective, & Behavioral Neuroscience 2023, 23: 459-464. PMID: 37222931, DOI: 10.3758/s13415-023-01111-6.Peer-Reviewed Original ResearchNeural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach
Jia R, Ruderman L, Pietrzak R, Gordon C, Ehrlich D, Horvath M, Mirchandani S, DeFontes C, Southwick S, Krystal J, Harpaz-Rotem I, Levy I. Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach. Translational Psychiatry 2023, 13: 101. PMID: 36977676, PMCID: PMC10050320, DOI: 10.1038/s41398-023-02388-4.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderValuation systemStress disorderCombat veteransMaintenance of PTSDSubjective valueBrain valuation systemNeural valuation systemVentromedial prefrontal cortexFunctional MRI studyFunction of symptomsMale combat veteransNeural valuationSeries of choicesFear learningPunishment processingPosttrauma symptomsPTSD symptomsNeural encodingNeural mechanismsUncertain optionsPrefrontal cortexSubjective valuationVentral striatumMonetary gainsThe composition of the choice set modulates probability weighting in risky decisions
Grubb M, Li Y, Larisch R, Hartmann J, Gottlieb J, Levy I. The composition of the choice set modulates probability weighting in risky decisions. Cognitive, Affective, & Behavioral Neuroscience 2023, 23: 666-677. PMID: 36702993, DOI: 10.3758/s13415-023-01062-y.Peer-Reviewed Original ResearchEvaluating the Evidence for Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma
Ben-Zion Z, Spiller T, Keynan J, Admon R, Levy I, Liberzon I, Shalev A, Hendler T, Harpaz-Rotem I. Evaluating the Evidence for Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma. American Journal Of Psychiatry 2023, 180: 146-154. PMID: 36628514, PMCID: PMC9898083, DOI: 10.1176/appi.ajp.20220271.Peer-Reviewed Original ResearchConceptsPosttraumatic psychopathologyPsychiatric vulnerabilityGeneral hospital emergency departmentHospital emergency departmentRecent trauma survivorsAdditional replication studiesEmergency departmentObjective neural markersDifferent longitudinal patternsProspective symptomsMonths posttraumaAcute aftermathPsychiatric disordersEffective personalized treatmentTrauma exposureFunctional MRIPersonalized treatmentConsistent subgroupTreatment implicationsNeural activityAssessment 1Neural markersLongitudinal studyNeurobiological indicesDiagnostic methods
2017
Distributed neural representation of saliency controlled value and category during anticipation of rewards and punishments
Zhang Z, Fanning J, Ehrlich DB, Chen W, Lee D, Levy I. Distributed neural representation of saliency controlled value and category during anticipation of rewards and punishments. Nature Communications 2017, 8: 1907. PMID: 29203854, PMCID: PMC5714958, DOI: 10.1038/s41467-017-02080-4.Peer-Reviewed Original ResearchConceptsNeural representationAnticipation of rewardDecision-related informationCognitive neuroscienceOutcome anticipationValue signalsPotential confoundsCategory informationHuman brainNeural signalsSaliencyRewardValuation taskAnticipationMultiple aspectsStrong supportActivity patternsPunishmentVmPFCRepresentationNeuroscienceConfoundsExtensive literatureEncodingTask
2016
Neuroanatomy accounts for age-related changes in risk preferences
Grubb MA, Tymula A, Gilaie-Dotan S, Glimcher PW, Levy I. Neuroanatomy accounts for age-related changes in risk preferences. Nature Communications 2016, 7: 13822. PMID: 27959326, PMCID: PMC5159889, DOI: 10.1038/ncomms13822.Peer-Reviewed Original ResearchConceptsRight posterior parietal cortexGray matter volumeRisky rewardMatter volumeAge-related changesLess grey matter volumePosterior parietal cortexAge-related declineRisk preferencesNeural mechanismsRisky choiceParietal regionsParietal cortexSubstantial empirical evidenceOlder adultsHealthy agingYoung adultsRewardGray matter lossEmpirical evidencePotential outcomesHuman agingAdultsPreferencesNeuroanatomy
2014
Neuroanatomy Predicts Individual Risk Attitudes
Gilaie-Dotan S, Tymula A, Cooper N, Kable JW, Glimcher PW, Levy I. Neuroanatomy Predicts Individual Risk Attitudes. Journal Of Neuroscience 2014, 34: 12394-12401. PMID: 25209279, PMCID: PMC4160774, DOI: 10.1523/jneurosci.1600-14.2014.Peer-Reviewed Original ResearchConceptsGray matter volumeMatter volumeHigher gray matter volumeIndividual risk attitudesRight posterior parietal cortexSecond groupWhole-brain analysisPosterior parietal cortexPossible neural mechanismsCortical volumeGeneral populationBrain areasBrain scansParietal cortexIndividual human brainsStable biomarkersNeural activationRisk attitudesLess risk aversionNeurobiological toolsAmerican adultsMultitude of studiesNeural mechanismsHuman brainEx-ante hypothesesImpaired Associative Learning with Food Rewards in Obese Women
Zhang Z, Manson KF, Schiller D, Levy I. Impaired Associative Learning with Food Rewards in Obese Women. Current Biology 2014, 24: 1731-1736. PMID: 25042588, DOI: 10.1016/j.cub.2014.05.075.Peer-Reviewed Original ResearchConceptsObese womenReward-based associative learningLearning deficitsBody mass indexHigh-calorie foodsObese menObese participantsMass indexFood rewardObesityReward circuitRewarding propertiesCue-reward associationsMajor epidemicsType of foodSuch impairmentImpairmentWomenMultiple regression analysisRegression analysisDysfunctionFemale participantsAssociative learningMoney rewardsNegative association
2013
Like cognitive function, decision making across the life span shows profound age-related changes
Tymula A, Belmaker L, Ruderman L, Glimcher PW, Levy I. Like cognitive function, decision making across the life span shows profound age-related changes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 17143-17148. PMID: 24082105, PMCID: PMC3801020, DOI: 10.1073/pnas.1309909110.Peer-Reviewed Original ResearchConceptsCognitive functionLoss domainHuman cognitive functionsLate life spanProfound age-related changesAge-related changesChoice consistencyHealthy eldersYounger peersAge-related patternsGain domainOlder adultsYoung adulthoodDecision-making functionsAmbiguity attitudesLife spanShaped functionAmbiguity aversionRisk attitudesChoice rationalityAttitudesYoung subjectsEldersSpanAdolescents
2001
Center–periphery organization of human object areas
Levy I, Hasson U, Avidan G, Hendler T, Malach R. Center–periphery organization of human object areas. Nature Neuroscience 2001, 4: 533-539. PMID: 11319563, DOI: 10.1038/87490.Peer-Reviewed Original ResearchConceptsVisual field biasPeripheral visual field biasOccipito-temporal cortexFace-related regionsMore peripheral informationObject-related areasRepresentation of objectsObject representationsObject categoriesEccentricity mapCentral informationPeripheral informationBrain regionsVisual field representationField biasRetinal eccentricity