2023
Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach
Jia R, Ruderman L, Pietrzak R, Gordon C, Ehrlich D, Horvath M, Mirchandani S, DeFontes C, Southwick S, Krystal J, Harpaz-Rotem I, Levy I. Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach. Translational Psychiatry 2023, 13: 101. PMID: 36977676, PMCID: PMC10050320, DOI: 10.1038/s41398-023-02388-4.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderValuation systemStress disorderCombat veteransMaintenance of PTSDSubjective valueBrain valuation systemNeural valuation systemVentromedial prefrontal cortexFunctional MRI studyFunction of symptomsMale combat veteransNeural valuationSeries of choicesFear learningPunishment processingPosttrauma symptomsPTSD symptomsNeural encodingNeural mechanismsUncertain optionsPrefrontal cortexSubjective valuationVentral striatumMonetary gains
2012
P-786 - The neural correlates of aversive learning among PTSD patients
Harpaz-Rotem I, Levy I, Schiller D. P-786 - The neural correlates of aversive learning among PTSD patients. European Psychiatry 2012, 27: 1. DOI: 10.1016/s0924-9338(12)74953-2.Peer-Reviewed Original ResearchFear responsesPTSD patientsUnconditioned stimulusAcquisition of fearAversive unconditioned stimulusContext of PTSDExtinction learningFear acquisitionFear extinctionFear learningNeural correlatesReversal learningAversive learningReversal taskDistinct predictionsReinforcement contingenciesHealthy controlsPTSDFirst CSCombat situationsStimuliLearningGSR dataDiminished abilityContext of war