Featured Publications
Morphea after Borrelia-induced facial nerve palsy
Xie CB, Cowper S, Odell ID. Morphea after Borrelia-induced facial nerve palsy. Journal Of Scleroderma And Related Disorders 2020, 6: 111-113. PMID: 35382252, PMCID: PMC8922639, DOI: 10.1177/2397198320956892.Peer-Reviewed Case Reports and Technical NotesFacial nerve palsyNerve palsyDevelopment of morpheaLocal immune toleranceFacial nerve paralysisAutoimmune phenomenaMost patientsNerve paralysisExact pathogenesisImmune toleranceAutoimmune diseasesHost antigensLocalized sclerodermaCommon causeFamily historyMorpheaEndemic areasGenetic predispositionPrevious episodesPalsyYoung menPrevious casesEnvironmental insultsInfectionBorreliaImprovement of pterygium inversum unguis and Raynaud phenomenon with interdigital botulinum toxin injections
Kim DJ, Odell ID. Improvement of pterygium inversum unguis and Raynaud phenomenon with interdigital botulinum toxin injections. JAAD Case Reports 2022, 26: 79-81. PMID: 35942355, PMCID: PMC9356022, DOI: 10.1016/j.jdcr.2022.06.009.Peer-Reviewed Original ResearchVibrational optical coherence tomography detects unique skin fibrotic states: Preliminary results of animal and human studies
Odell ID, Flavell RA, Silver FH. Vibrational optical coherence tomography detects unique skin fibrotic states: Preliminary results of animal and human studies. Journal Of The American Academy Of Dermatology 2020, 85: 780-782. PMID: 32860914, PMCID: PMC9793292, DOI: 10.1016/j.jaad.2020.08.091.Peer-Reviewed Original ResearchEpiregulin is a dendritic cell–derived EGFR ligand that maintains skin and lung fibrosis
Odell I, Steach H, Gauld S, Reinke-Breen L, Karman J, Carr T, Wetter J, Phillips L, Hinchcliff M, Flavell R. Epiregulin is a dendritic cell–derived EGFR ligand that maintains skin and lung fibrosis. Science Immunology 2022, 7: eabq6691. PMID: 36490328, PMCID: PMC9840167, DOI: 10.1126/sciimmunol.abq6691.Peer-Reviewed Original ResearchConceptsLung fibrosisDendritic cellsImmune cellsDiffuse cutaneous systemic sclerosisPersistence of fibrosisCutaneous systemic sclerosisExtent of fibrosisType I interferonSystemic sclerosisAutoimmune diseasesAntifibrotic targetsTherapeutic administrationMouse modelI interferonLung samplesLung explantsFibrosisFibrotic tissueImmune signalsEpiregulin expressionPatient's skinExtracellular matrix productionGenetic deficiencyEpiregulinEGFR ligands
2024
VEXAS Syndrome: Histiocytoid Cells With Feathery Cytoplasm as a Clue to the Diagnosis
Ko C, Odell I, Gehlhausen J, Leventhal J, McNiff J, Zubek A. VEXAS Syndrome: Histiocytoid Cells With Feathery Cytoplasm as a Clue to the Diagnosis. Journal Of Cutaneous Pathology 2024 PMID: 39610062, DOI: 10.1111/cup.14757.Peer-Reviewed Original ResearchCross-tissue organization of myeloid cells in scleroderma and related fibrotic diseases
Odell I. Cross-tissue organization of myeloid cells in scleroderma and related fibrotic diseases. Current Opinion In Rheumatology 2024, 36: 379-386. PMID: 39171604, PMCID: PMC11451931, DOI: 10.1097/bor.0000000000001047.Peer-Reviewed Original ResearchScRNA-seqIdiopathic pulmonary fibrosisMyeloid cell typesScRNA-seq studiesScRNA-seq analysisSingle-cell RNA sequencingCell typesDendritic cellsFc receptor genesScleroderma skinExpression of EREGLung fibrosis severityFibrotic diseasesMyeloid cell populationsRNA sequencingMultiple tissuesSignaling mechanismsReceptor geneMyeloid cellsSSc skinPulmonary fibrosisFibrosis severityLung fibrosisCardiac fibrosisSPP1029 Investigation of cGAS-STING signaling in scleroderma and GvHD Skin
Newton N, Odell A, Odell I. 029 Investigation of cGAS-STING signaling in scleroderma and GvHD Skin. Journal Of Investigative Dermatology 2024, 144: s5. DOI: 10.1016/j.jid.2024.06.045.Peer-Reviewed Original ResearchLB931 Treatment of chronic graft-versus-host disease with combination extracorporeal photopheresis and the ROCK2 inhibitor belumosudil can reverse sclerodermatous changes
Swallow M, Chang J, Carlson K, Odell I, Girardi M. LB931 Treatment of chronic graft-versus-host disease with combination extracorporeal photopheresis and the ROCK2 inhibitor belumosudil can reverse sclerodermatous changes. Journal Of Investigative Dermatology 2024, 144: s163. DOI: 10.1016/j.jid.2024.06.1104.Peer-Reviewed Original ResearchGene trajectory inference for single-cell data by optimal transport metrics
Qu R, Cheng X, Sefik E, Stanley III J, Landa B, Strino F, Platt S, Garritano J, Odell I, Coifman R, Flavell R, Myung P, Kluger Y. Gene trajectory inference for single-cell data by optimal transport metrics. Nature Biotechnology 2024, 1-11. PMID: 38580861, PMCID: PMC11452571, DOI: 10.1038/s41587-024-02186-3.Peer-Reviewed Original ResearchGene dynamicsGene programTrajectory inferenceBiological processesCell-cell graphDynamics of genesCell trajectory inferenceSingle-cell RNA sequencingSingle-cell dataCell state transitionsMyeloid lineage maturationDynamics of biological processesGene distributionRNA sequencingPseudotemporal orderingGene processingTrajectories of cellsGenesActivity of biological processesTechnical noiseGroups of cellsLineage maturationCellsConstruct cellsSequenceTGF-β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease
Pellowe A, Wu M, Kang T, Chung T, Ledesma-Mendoza A, Herzog E, Levchenko A, Odell I, Varga J, Gonzalez A. TGF-β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease. American Journal Of Pathology 2024, 194: 1171-1184. PMID: 38548268, PMCID: PMC11220919, DOI: 10.1016/j.ajpath.2024.02.021.Peer-Reviewed Original Research
2023
IL-6 trans-signaling in a humanized mouse model of scleroderma
Odell I, Agrawal K, Sefik E, Odell A, Caves E, Kirkiles-Smith N, Horsley V, Hinchcliff M, Pober J, Kluger Y, Flavell R. IL-6 trans-signaling in a humanized mouse model of scleroderma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2306965120. PMID: 37669366, PMCID: PMC10500188, DOI: 10.1073/pnas.2306965120.Peer-Reviewed Original ResearchConceptsBone marrow-derived immune cellsIL-6Human hematopoietic stem cellsImmune cellsT cellsScleroderma skinSoluble IL-6 receptorCD8 T cellsHumanized mouse modelPathogenesis of sclerodermaMesenchymal cellsFibroblast-derived IL-6IL-6 receptorIL-6 signalingT cell activationHuman IL-6Human T cellsExpression of collagenFibrosis improvementPansclerotic morpheaHuman endothelial cellsHumanized miceReduced markersSkin graftsHuman CD4
2022
Amelanotic melanoma in a patient with Hermansky-Pudlak syndrome
Fan R, Johnston MS, Gowen MF, Damsky W, Odell I, Clune J, Vesely MD. Amelanotic melanoma in a patient with Hermansky-Pudlak syndrome. JAAD Case Reports 2022, 27: 61-63. PMID: 35990226, PMCID: PMC9388864, DOI: 10.1016/j.jdcr.2022.06.035.Peer-Reviewed Case Reports and Technical NotesInhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis
Damsky W, Wang A, Kim DJ, Young BD, Singh K, Murphy MJ, Daccache J, Clark A, Ayasun R, Ryu C, McGeary MK, Odell ID, Fazzone-Chettiar R, Pucar D, Homer R, Gulati M, Miller EJ, Bosenberg M, Flavell RA, King B. Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis. Nature Communications 2022, 13: 3140. PMID: 35668129, PMCID: PMC9170782, DOI: 10.1038/s41467-022-30615-x.Peer-Reviewed Original ResearchConceptsType 1 immunityInternal organ involvementOrgan involvementT cell-derived IFNIdiopathic inflammatory disorderOpen-label trialMonths of treatmentType 1 cytokinesJanus kinase inhibitorImmunologic changesLongstanding sarcoidosisSarcoidosis activitySarcoidosis symptomsClinical improvementCutaneous sarcoidosisSecondary outcomesComplete responsePrimary outcomeTofacitinib treatmentActivity scoreCytokine mediatorsIL-12IL-15IL-6Inflammatory disorders
2021
Squamous cell carcinoma arising in long-standing necrobiosis lipoidica treated with radical resection and split-thickness skin graft
Xie CB, Ring N, Damsky W, McNiff JM, Olino K, Odell I. Squamous cell carcinoma arising in long-standing necrobiosis lipoidica treated with radical resection and split-thickness skin graft. JAAD Case Reports 2021, 19: 90-93. PMID: 35024397, PMCID: PMC8724883, DOI: 10.1016/j.jdcr.2021.11.005.Peer-Reviewed Case Reports and Technical NotesA novel NFkB1 mutation linking pyoderma gangrenosum and common variable immunodeficiency
Sun Q, Gehlhausen JR, Freudzon M, Kibbi N, Bale A, Choate K, Tomayko M, Odell I, Ramachandran S. A novel NFkB1 mutation linking pyoderma gangrenosum and common variable immunodeficiency. JAAD Case Reports 2021, 18: 61-63. PMID: 34825039, PMCID: PMC8605275, DOI: 10.1016/j.jdcr.2021.10.015.Peer-Reviewed Original ResearchNew bullous lesions in a 72-year-old woman
Mendoza H, Goodwin J, Gehlhausen J, Odell I, McNiff J, Gnanapandithan K. New bullous lesions in a 72-year-old woman. Cleveland Clinic Journal Of Medicine 2021, 88: 319-324. PMID: 34078615, DOI: 10.3949/ccjm.88a.20180.Peer-Reviewed Case Reports and Technical Notes
2020
Skin puckering and edema during durvalumab therapy
Olamiju B, Odell I, Panse G, Eder JP, Leventhal JS. Skin puckering and edema during durvalumab therapy. JAAD Case Reports 2020, 7: 110-112. PMID: 33364282, PMCID: PMC7750709, DOI: 10.1016/j.jdcr.2020.11.019.Peer-Reviewed Original ResearchA novel medical student initiative to enhance provision of teledermatology in a resident continuity clinic during the COVID‐19 pandemic: a pilot study
Belzer A, Olamiju B, Antaya RJ, Odell ID, Bia M, Perkins SH, Cohen JM. A novel medical student initiative to enhance provision of teledermatology in a resident continuity clinic during the COVID‐19 pandemic: a pilot study. International Journal Of Dermatology 2020, 60: 128-129. PMID: 33226121, PMCID: PMC7753449, DOI: 10.1111/ijd.15322.Peer-Reviewed Original Research
2019
HER2 joins AKT to inhibit STING immunity
Odell ID, Flavell RA. HER2 joins AKT to inhibit STING immunity. Nature Cell Biology 2019, 21: 917-918. PMID: 31371829, DOI: 10.1038/s41556-019-0368-4.Peer-Reviewed Original Research
2018
A case of subungual tumors of incontinentia pigmenti: A rare manifestation and association with bipolar disease
Kibbi N, Totonchy M, Suozzi KC, Ko CJ, Odell ID. A case of subungual tumors of incontinentia pigmenti: A rare manifestation and association with bipolar disease. JAAD Case Reports 2018, 4: 737-741. PMID: 30167449, PMCID: PMC6113656, DOI: 10.1016/j.jdcr.2018.03.018.Peer-Reviewed Original Research