A systematic RNAi screen for longevity genes in C. elegans
Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS. A systematic RNAi screen for longevity genes in C. elegans. Genes & Development 2005, 19: 1544-1555. PMID: 15998808, PMCID: PMC1172061, DOI: 10.1101/gad.1308205.Peer-Reviewed Original ResearchConceptsLongevity genesGenome-wide functional genomics screenDAF-16/FOXO transcription factorRNA interferenceDAF-16/FOXONew longevity genesSystematic RNAi screenFunctional genomic screensFOXO transcription factorsLarge-scale RNA interferenceCandidate longevity genesRNAi inactivationAnimal phylogenyRNAi screenC. elegansGenetic interactionsGenomic screenSignal transductionTranscription factorsDaf-2Gene expressionProtein deacetylaseProtein turnoverGenesPathway