Comparison of the Cellsearch Profile Kit (CPK) with the Standard Cellsearch Epithelial Kit (CEK) Demonstrates the CPK Produces Higher Circulating Tumor Cell (CTC) Yields and Is Better Suited for Use in Obtaining CTC's for Molecular Characterization.
Flores L, Kindelberger D, Ligon A, Cappeletti M, Fiorentino M, Loda M, Cibas E, Janne P, Krop I. Comparison of the Cellsearch Profile Kit (CPK) with the Standard Cellsearch Epithelial Kit (CEK) Demonstrates the CPK Produces Higher Circulating Tumor Cell (CTC) Yields and Is Better Suited for Use in Obtaining CTC's for Molecular Characterization. Cancer Research 2009, 69: 3003-3003. DOI: 10.1158/0008-5472.sabcs-09-3003.Peer-Reviewed Original ResearchML of bloodTumor cellsBreast cancerCytospin slidesLow intrapatient variabilityHER2 gene copy numberMetastatic breast cancerPeripheral blood samplesBC cell linesMedian cell countTumor cell yieldMean total numberMetastatic tumor cellsPrimary cancerCD45 stainingPredictive biomarkersMechanisms of resistanceHealthy controlsIntrapatient variabilityMetastatic cancerCTC yieldPharmacodynamic studiesSolid cancersCytokeratin stainingBlood samples