Epithelial and Stromal Cathepsin K and CXCL14 Expression in Breast Tumor Progression
Kleer CG, Bloushtain-Qimron N, Chen YH, Carrasco D, Hu M, Yao J, Kraeft SK, Collins LC, Sabel MS, Argani P, Gelman R, Schnitt SJ, Krop IE, Polyak K. Epithelial and Stromal Cathepsin K and CXCL14 Expression in Breast Tumor Progression. Clinical Cancer Research 2008, 14: 5357-5367. PMID: 18765527, PMCID: PMC2630242, DOI: 10.1158/1078-0432.ccr-08-0732.Peer-Reviewed Original ResearchConceptsBreast tumor progressionTumor epithelial cellsTumor progressionCathepsin KCTSK inhibitorsEpithelial cellsCXCL14 expressionBiopsy siteHuman breast tumor progressionBreast stromal fibroblastsExpression of CXCL14Higher tumor stageInvasive breast tumorsNormal breast tissueOverall survivalPatient characteristicsClinical outcomesHistopathologic characteristicsDuctal carcinomaTumor stageStromal expressionSitu carcinomaClinical roleEpithelial expressionImmunohistochemical analysis