2020
Optimizing Radiation Therapy to Boost Systemic Immune Responses in Breast Cancer: A Critical Review for Breast Radiation Oncologists
Ho AY, Wright JL, Blitzblau RC, Mutter RW, Duda D, Norton L, Bardia A, Spring L, Isakoff SJ, Chen JH, Grassberger C, Bellon JR, Beriwal S, Khan AJ, Speers C, Dunn SA, Thompson A, Santa-Maria CA, Krop IE, Mittendorf E, King TA, Gupta GP. Optimizing Radiation Therapy to Boost Systemic Immune Responses in Breast Cancer: A Critical Review for Breast Radiation Oncologists. International Journal Of Radiation Oncology • Biology • Physics 2020, 108: 227-241. PMID: 32417409, PMCID: PMC7646202, DOI: 10.1016/j.ijrobp.2020.05.011.Peer-Reviewed Original ResearchConceptsBreast cancerRadiation therapyTiming of RTImmune checkpoint blockadeSystemic immune responsesEffector immune cellsSystemic antitumor effectsBreast radiation oncologistsTypes of cancerCheckpoint blockadeTumor immunogenicityImmune cellsClinical trialsImmune responseSystemic effectsAntitumor effectsTranslational studiesHigh dosesRadiation oncologistsImmunotherapyCancerDistant sitesTherapyFurther explorationOncologists
2019
Current Landscape of Immunotherapy in Breast Cancer
Adams S, Gatti-Mays ME, Kalinsky K, Korde LA, Sharon E, Amiri-Kordestani L, Bear H, McArthur HL, Frank E, Perlmutter J, Page DB, Vincent B, Hayes JF, Gulley JL, Litton JK, Hortobagyi GN, Chia S, Krop I, White J, Sparano J, Disis ML, Mittendorf EA. Current Landscape of Immunotherapy in Breast Cancer. JAMA Oncology 2019, 5: 1205-1214. PMID: 30973611, PMCID: PMC8452050, DOI: 10.1001/jamaoncol.2018.7147.Peer-Reviewed Original ResearchImmune checkpoint blockadeBreast cancerForm of immunotherapyLocal ablative therapyRobust predictive biomarkersCancer immunotherapy trialsAppropriate end pointsCombination therapy strategiesAdditional chemotherapeutic agentsCheckpoint blockadeMetastatic diseaseObjective responseImmunotherapy trialsClinical efficacyAblative therapyPredictive biomarkersClinical trialsImmune responseThoughtful study designImmunotherapyBreast tumorsChemotherapeutic agentsNarrative reviewCancerEnd point