2007
Circulating stem cells in extremely preterm neonates
Bizzarro MJ, Bhandari V, Krause DS, Smith BR, Gross I. Circulating stem cells in extremely preterm neonates. Acta Paediatrica 2007, 96: 521-525. PMID: 17391470, DOI: 10.1111/j.1651-2227.2007.00194.x.Peer-Reviewed Original ResearchConceptsWeeks of lifePreterm neonatesNeonatal morbidityPulmonary functionPremature neonatesGestational agePeripheral bloodInitial CD34Median gestational agePulmonary function testsShort-term outcomesUmbilical cord bloodFunction testsNeonatal demographicsBirth weightCord bloodRespiratory diseaseNeonatesCell countCD34Progenitor cellsInverse correlationWeeksBloodMorbidity
2005
Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with congenital heart disease
Bizzarro M, Gross I. Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with congenital heart disease. 2005, cd005055. PMID: 16235391, DOI: 10.1002/14651858.cd005055.pub2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMean pulmonary arterial pressurePulmonary hypertensive crisisCongenital heart diseaseLong-term mortalityHeart diseasePulmonary hypertensionHeart rateHospital stayArterial pressureNitric oxidePostoperative managementMethodologic qualityMethaemoglobin levelsNeurodevelopmental disabilitiesEfficacy of iNOUse of iNOCochrane Central RegisterPulmonary arterial pressureSystemic blood pressureSubgroup of patientsHigh methodologic qualityMajority of outcomesMarkers of toxicityConventional managementHypertensive crisis
2004
Rest-Activity Patterns of Premature Infants Are Regulated by Cycled Lighting
Rivkees SA, Mayes L, Jacobs H, Gross I. Rest-Activity Patterns of Premature Infants Are Regulated by Cycled Lighting. Pediatrics 2004, 113: 833-839. PMID: 15060235, DOI: 10.1542/peds.113.4.833.Peer-Reviewed Original ResearchConceptsExperimental group infantsWeeks postmenstrual agePremature infantsPostmenstrual ageGroup infantsRest-activity patternsControl subjectsNeonatal intensive care unit roomsIntensive care unit roomsHospitalized premature infantsControl infantsDay-night rhythmHospital nurseryHead circumferenceDistinct patternsInfantsActivity patternsSolar light-dark cycleUnit roomsHospitalDim lightingAgeDay-night differenceMonthsDays
2001
Is there a role for antenatal TRH therapy for the prevention of neonatal lung disease?
Gross I, Moya F. Is there a role for antenatal TRH therapy for the prevention of neonatal lung disease? Seminars In Perinatology 2001, 25: 406-416. PMID: 11778911, DOI: 10.1053/sper.2001.29032.Peer-Reviewed Original ResearchConceptsAntenatal thyrotropin-releasing hormoneThyrotropin-releasing hormoneRespiratory distress syndromeSurfactant therapyDistress syndromeOxygen dependencyAntenatal glucocorticoid treatmentLight-headed feelingPatent ductus arteriosusRetinopathy of prematurityNeonatal lung diseaseRandomized clinical trialsPituitary-thyroid axisAddition of TRHAntenatal glucocorticoidsGlucocorticoid therapyMaternal therapyNeonatal complicationsTransient complicationsTRH therapyHormone therapyBlood pressureDuctus arteriosusGlucocorticoid treatmentLung disease
2000
Recent Advances in Respiratory Care of the Term Neonate
GROSS I. Recent Advances in Respiratory Care of the Term Neonate. Annals Of The New York Academy Of Sciences 2000, 900: 151-158. PMID: 10818401, DOI: 10.1111/j.1749-6632.2000.tb06225.x.ChaptersConceptsConventional ventilationLong-term neurologic outcomeHours of diagnosisNear-term infantsPersistent pulmonary hypertensionNitric oxide therapyChronic lung diseaseHigh-frequency ventilationHigh-frequency ventilatorNeurologic outcomePulmonary hypertensionTerm neonatesMembrane oxygenationRespiratory distressLung diseaseRespiratory careMajor causeTreatment regimesVentilationMorbidityInfantsTherapyMortalityHypertensionCyanosis
1997
Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn
Roberts J, Fineman J, Morin F, Shaul P, Rimar S, Schreiber M, Polin R, Zwass M, Zayek M, Gross I, Heymann M, Zapol W, Thusu K, Zellers T, Wylam M, Zaslavsky A. Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn. New England Journal Of Medicine 1997, 336: 605-610. PMID: 9032045, DOI: 10.1056/nejm199702273360902.Peer-Reviewed Original ResearchConceptsPersistent pulmonary hypertensionPulmonary vascular resistanceExtracorporeal membrane oxygenationPulmonary hypertensionSystemic oxygenationNitric oxideSevere hypoxemiaVascular resistanceMembrane oxygenationSystemic arterial hypoxemiaSystemic blood pressureLong-term therapyFull-term infantsNumber of deathsSystemic hypotensionArterial hypoxemiaBlood pressureMulticenter studyConventional therapyAlternative therapiesInvasive treatmentNitric oxide groupHypertensionInitial improvementMethemoglobin levels
1993
Combined hormonal therapy for the prevention of respiratory distress syndrome and its consequences.
Moya F, Gross I. Combined hormonal therapy for the prevention of respiratory distress syndrome and its consequences. Seminars In Perinatology 1993, 17: 267-74. PMID: 8140441.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAntenatal steroidsPostnatal surfactantSurfactant therapyPostnatal surfactant therapyRespiratory distress syndromeSteroid therapyHormonal therapyDistress syndromePremature infantsTherapyNumber of centersEnd pointRoutine useSteroidsTRHMaturation profileApparent benefitPatientsInfantsDeathTerms of RDCLDWidespread useSyndromeComparable data
1992
Plasma Thyroid Hormones and Prolactin in Premature Infants and Their Mothers after Prenatal Treatment with Thyrotropin-Releasing Hormone
Ballard P, Ballard R, Creasy R, Padbury J, Polk D, Bracken M, Moya F, Gross I. Plasma Thyroid Hormones and Prolactin in Premature Infants and Their Mothers after Prenatal Treatment with Thyrotropin-Releasing Hormone. Pediatric Research 1992, 32: 673-678. PMID: 1287557, DOI: 10.1203/00006450-199212000-00009.Peer-Reviewed Original ResearchConceptsThyroid hormonesFree thyroxineThyrotropin-releasing hormone treatmentNewborn lung diseaseDoses of TRHMU/LPituitary-thyroid functionPlasma of womenThyrotropin-Releasing HormoneWk of gestationPmol/LPlasma thyroid hormonesCord TSHTRH i.Preterm fetusesCord concentrationsControl infantsPremature infantsPostnatal surgeTRH administrationLung diseaseCord bloodPrenatal treatmentTriiodothyronine levelsHormone treatmentSurfactant protein C: hormonal control of SP-C mRNA levels in vitro
Veletza S, Nichols K, Gross I, Lu H, Dynia D, Floros J. Surfactant protein C: hormonal control of SP-C mRNA levels in vitro. American Journal Of Physiology 1992, 262: l684-l687. PMID: 1319687, DOI: 10.1152/ajplung.1992.262.6.l684.Peer-Reviewed Original ResearchMeSH Keywords8-Bromo Cyclic Adenosine MonophosphateAnalysis of VarianceAnimalsBase SequenceBucladesineCell NucleusCloning, MolecularDexamethasoneFetusGene LibraryHumansKineticsLungMolecular Sequence DataOligonucleotide ProbesOrgan Culture TechniquesProteolipidsPulmonary SurfactantsRatsRNA, MessengerTranscription, GeneticConceptsSP-C mRNA levelsSP-C mRNAMRNA levelsHormonal regulationSurfactant protein CSurfactant protein mRNAsTranscriptional assaysThyroid hormone T3Transcriptional stepNorthern blotCDNA probeProtein mRNACyclic monophosphateCAMP analogSpHormone T3Hormonal controlMRNASurfactant proteinsRegulationLung explantsDose-dependent increaseRat lung explantsExplantsProtein CRespiratory disease in very-low-birthweight infants after prenatal thyrotropin-releasing hormone and glucocorticoid
Ballard R, Ballard P, Bracken M, Moya F, Gross I, Creasy K, Padbury J, Polk D. Respiratory disease in very-low-birthweight infants after prenatal thyrotropin-releasing hormone and glucocorticoid. The Lancet 1992, 339: 510-515. PMID: 1346877, DOI: 10.1016/0140-6736(92)90337-3.Peer-Reviewed Original ResearchMeSH KeywordsBetamethasoneChronic DiseaseDouble-Blind MethodDrug Therapy, CombinationFemaleHumansInfant, Low Birth WeightInfant, NewbornInfant, Premature, DiseasesLung DiseasesMalePregnancyPrenatal CareRespiration, ArtificialRespiratory Distress Syndrome, NewbornRisk FactorsThyrotropin-Releasing HormoneConceptsChronic lung diseaseThyrotropin-releasing hormoneRespiratory distress syndromePrenatal thyrotropin-releasing hormoneDistress syndromePostconceptional ageBirthweight infantsLung diseaseSevere respiratory distress syndromeSteroid-alone groupNeonatal respiratory morbidityComplications of prematurityUnadjusted relative riskPrenatal glucocorticoid treatmentWeeks postconceptional ageTRH therapyPreterm deliveryRespiratory morbidityWeeks' gestationGlucocorticoid treatmentNeonatal periodAdverse outcomesTotal incidencePrenatal treatmentRelative risk
1990
Regulation of fetal lung maturation
Gross I. Regulation of fetal lung maturation. American Journal Of Physiology 1990, 259: l337-l344. PMID: 2260669, DOI: 10.1152/ajplung.1990.259.6.l337.Peer-Reviewed Original ResearchConceptsSurfactant proteinsEpithelial cell developmentCell developmentRecent identificationMolecular levelGenesPhospholipid synthesisProteinHormonal regulationSpecies differencesCurrent knowledgeLung developmentRegulationCyclic monophosphateSame hormonesMaturationExpressionPrevious studiesNotable differencesHormoneMonophosphateIdentification
1989
Survival of infants with persistent pulmonary hypertension without extracorporeal membrane oxygenation.
Dworetz A, Moya F, Sabo B, Gladstone I, Gross I. Survival of infants with persistent pulmonary hypertension without extracorporeal membrane oxygenation. Pediatrics 1989, 84: 1-6. PMID: 2740158, DOI: 10.1542/peds.84.1.1.Peer-Reviewed Original ResearchConceptsPersistent pulmonary hypertensionPulmonary hypertensionExtracorporeal membrane oxygenation therapyCorresponding survival figuresMembrane oxygenation therapyExtracorporeal membrane oxygenationRecords of infantsSurvival of infantsConservative therapyMembrane oxygenationOxygenation therapySurvival figuresRetrospective evaluationMortality rateHypertensionECMOTherapyPatientsInfantsConservative approachSurvivalEarly periodHyperventilationCriteriaMainstay
1988
Prevention of respiratory distress syndrome.
Moya F, Gross I. Prevention of respiratory distress syndrome. Seminars In Perinatology 1988, 12: 348-58. PMID: 3146813.Chapters
1987
The Biochemistry of Fetal Lung Development
Kresch M, Gross I. The Biochemistry of Fetal Lung Development. Clinics In Perinatology 1987, 14: 481-507. PMID: 3311536, DOI: 10.1016/s0095-5108(18)30747-4.ChaptersConceptsSurfactant therapyLung complianceLung maturationAdministration of betamethasoneEffects of glucocorticoidsFetal lung developmentNumber of alveoliGlucocorticoid therapyFetal rabbitsLung developmentTherapyAnimal dataTissue complianceHormonal enhancementAdditive effectAdministrationComplianceMaturationRDSMorbidityBetamethasoneGlucocorticoidsLungMortalitySteroids
1986
Response of the Maternal, Fetal, and Neonatal Pituitary-Thyroid Axis to Thyrotropin-Releasing Hormone
Moya F, Mena P, Heusser F, Foradori A, Paiva E, Yazigi R, Michaud P, Gross I. Response of the Maternal, Fetal, and Neonatal Pituitary-Thyroid Axis to Thyrotropin-Releasing Hormone. Pediatric Research 1986, 20: 982-986. PMID: 3095783, DOI: 10.1203/00006450-198610000-00018.Peer-Reviewed Original ResearchConceptsFetal TSHMaternal administrationPostnatal increaseElective cesarean sectionThyrotropin-Releasing HormonePituitary-thyroid axesPituitary-thyroid axisMaternal T3Maternal TSHCesarean sectionPostnatal surgePregnant womenTRH administrationPrenatal exposureFetal pituitarySignificant elevationHigh doseT3 levelsHigh dosesTRHTSHPrior exposureAdministrationNeonatesSignificant increase
1984
Management of spina bifida in the newborn infant.
Duncan C, Ment L, Ehrenkranz R, Gross I, Hobbins J, McClure M. Management of spina bifida in the newborn infant. Connecticut Medicine 1984, 48: 349-52. PMID: 6378514.Peer-Reviewed Original Research
1983
Lung surfactant in the hyperinsulinemic fetal monkey
Rooney S, Chu A, Gross I, Marino P, Schwartz R, Seghal P, Singer D, Susa J, Warshaw J, Wilson C. Lung surfactant in the hyperinsulinemic fetal monkey. Lung 1983, 161: 313-317. PMID: 6355669, DOI: 10.1007/bf02713877.Peer-Reviewed Original ResearchConceptsAbsence of hyperglycemiaBlood insulin levelsFetal rhesus monkeysEffect of hyperinsulinemiaInfusion of insulinSurfactant productionLung surfactant productionDiabetic mothersAlzet minipumpsInsulin levelsD gestationFetal monkeysFetal primateLung lavageLung tissueDays gestationLung slicesBody weightControl groupRhesus monkeysHyperinsulinemiaGestationCholine incorporationInhibitory effectHuman infants
1981
A Half Century of Neonatal Sepsis at Yale: 1928 to 1978
Freedman R, Ingram D, Gross I, Ehrenkranz R, Warshaw J, Baltimore R. A Half Century of Neonatal Sepsis at Yale: 1928 to 1978. JAMA Pediatrics 1981, 135: 140-144. PMID: 7008583, DOI: 10.1001/archpedi.1981.02130260032010.Peer-Reviewed Original Research
1979
The Hormonal Regulation of Fetal Lung Maturation
Gross I. The Hormonal Regulation of Fetal Lung Maturation. Clinics In Perinatology 1979, 6: 377-395. PMID: 230006, DOI: 10.1016/s0095-5108(18)31155-2.ChaptersThyrotropin-Releasing Hormone Increases the Amount of Surfactant in Lung Lavage from Fetal Rabbits
Rooney S, Marino P, Gobran L, Gross I, Warshaw J. Thyrotropin-Releasing Hormone Increases the Amount of Surfactant in Lung Lavage from Fetal Rabbits. Pediatric Research 1979, 13: 623-625. PMID: 112569, DOI: 10.1203/00006450-197905000-00009.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneLung lavageLung maturationFetal lung slicesRespiratory distress syndromeFetal lung maturationPulmonary surfactant productionSurfactant productionPhosphatidylcholine/sphingomyelin ratioDistress syndromeTRH administrationPregnant rabbitsIncorporation of cholineFetal rabbitsGestation resultsLung slicesLavagePhysiologic roleFetusesSphingomyelin ratioTotal phospholipidsControl littersSurfactant releasePhospholipid contentMore phosphatidylcholine