1998
Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats
Jacobs H, Bogue C, Pinter E, Wilson C, Warshaw J, Gross I. Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats. Pediatric Research 1998, 44: 99-104. PMID: 9667378, DOI: 10.1203/00006450-199807000-00016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsButyratesButyric AcidDiabetes Mellitus, ExperimentalEmbryonic and Fetal DevelopmentFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxGestational AgeHistone Deacetylase InhibitorsLungOrgan Culture TechniquesPregnancyPregnancy in DiabeticsRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticConceptsLung developmentLung explantsSurfactant apoproteinExperimental animalsLung mRNA levelsElevated levelsEffect of diabetesFetal rat lung explantsLungs of fetusesRat lung explantsEffect of butyrateAntenatal exposureMaternal diabetesMetabolic abnormalitiesStreptozotocin treatmentLower incidenceNormal ratsDiabetesDexamethasoneLevel of expressionRatsTreatment of explantsSodium butyrateMRNA levelsAlters expression
1985
Delayed Pulmonary Maturation in the Fetus of the Streptozotocin-Diabetic Rat
Gewolb I, Rooney S, Barrett C, Ingleson L, Light D, Wilson C, Smith G, Gross I, Warshaw J. Delayed Pulmonary Maturation in the Fetus of the Streptozotocin-Diabetic Rat. Experimental Lung Research 1985, 8: 141-151. PMID: 4029093, DOI: 10.3109/01902148509057518.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, ExperimentalEmbryonic and Fetal DevelopmentFemaleLungPregnancyPregnancy in DiabeticsRatsRats, Inbred StrainsTime FactorsConceptsStreptozotocin-diabetic ratsDiabetic groupPulmonary maturationDay 21Lung developmentDelayed pulmonary maturationAlveolar lining cellsEffects of hyperglycemiaFetal lung developmentDays of gestationObserved developmental delayType II cellsControl lungsMaturational delayCholinephosphate cytidylyltransferase activityIntravenous injectionRat gestationDiabetic fetusesLining cellsDay 22Day 20FetusesActivity of enzymesDevelopmental delayDecreased number