1992
Surfactant protein C: hormonal control of SP-C mRNA levels in vitro
Veletza S, Nichols K, Gross I, Lu H, Dynia D, Floros J. Surfactant protein C: hormonal control of SP-C mRNA levels in vitro. American Journal Of Physiology 1992, 262: l684-l687. PMID: 1319687, DOI: 10.1152/ajplung.1992.262.6.l684.Peer-Reviewed Original ResearchMeSH Keywords8-Bromo Cyclic Adenosine MonophosphateAnalysis of VarianceAnimalsBase SequenceBucladesineCell NucleusCloning, MolecularDexamethasoneFetusGene LibraryHumansKineticsLungMolecular Sequence DataOligonucleotide ProbesOrgan Culture TechniquesProteolipidsPulmonary SurfactantsRatsRNA, MessengerTranscription, GeneticConceptsSP-C mRNA levelsSP-C mRNAMRNA levelsHormonal regulationSurfactant protein CSurfactant protein mRNAsTranscriptional assaysThyroid hormone T3Transcriptional stepNorthern blotCDNA probeProtein mRNACyclic monophosphateCAMP analogSpHormone T3Hormonal controlMRNASurfactant proteinsRegulationLung explantsDose-dependent increaseRat lung explantsExplantsProtein C
1991
Hormonal Effects on the Surfactant Protein B (SP-B) mRNA in Cultured Fetal Rat Lung
Floros J, Gross I, Nichols K, Veletza S, Dynia D, Lu H, Wilson C, Peterec S. Hormonal Effects on the Surfactant Protein B (SP-B) mRNA in Cultured Fetal Rat Lung. American Journal Of Respiratory Cell And Molecular Biology 1991, 4: 449-454. PMID: 1850607, DOI: 10.1165/ajrcmb/4.5.449.Peer-Reviewed Original Research
1990
Regulation of surfactant protein A mRNA by hormones and butyrate in cultured fetal rat lung
Nichols K, Floros J, Dynia D, Veletza S, Wilson C, Gross I. Regulation of surfactant protein A mRNA by hormones and butyrate in cultured fetal rat lung. American Journal Of Physiology 1990, 259: l488-l495. PMID: 2175559, DOI: 10.1152/ajplung.1990.259.6.l488.Peer-Reviewed Original Research8-Bromo Cyclic Adenosine MonophosphateAnimalsBucladesineButyratesButyric AcidDexamethasoneFetusGene Expression RegulationGlycoproteinsLungOrgan Culture TechniquesPhospholipidsProteolipidsPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated ProteinsPulmonary SurfactantsRatsRNA ProbesRNA, MessengerTriiodothyronine
1986
Glucocorticoid stimulation of choline-phosphate cytidylyltransferase activity in fetal rat lung: Receptor-response relationships
Rooney S, Dynia D, Smart D, Chu A, Ingleson L, Wilson C, Gross I. Glucocorticoid stimulation of choline-phosphate cytidylyltransferase activity in fetal rat lung: Receptor-response relationships. Biochimica Et Biophysica Acta 1986, 888: 208-216. PMID: 3017448, DOI: 10.1016/0167-4889(86)90023-6.Peer-Reviewed Original ResearchConceptsEffect of dexamethasoneDexamethasone bindingCholine-phosphate cytidylyltransferase activitySpecific dexamethasone bindingFetal lung maturationFetal rat lung explantsCholine-phosphate cytidylyltransferaseSpecific nuclear bindingCytidylyltransferase activityRat lung explantsReceptor-mediated processSupernatant fractionFetal rat lungDose-response curveDexamethasone-treated culturesLung maturationGlucocorticoid bindingGlucocorticoid actionDe novo phosphatidylcholine synthesisLung explantsRat lungDexamethasoneGlucocorticoid stimulationStimulatory effectCholine incorporation
1984
Corticosteroid binding by fetal rat and rabbit lung in organ culture
Ballard P, Ballard R, Gonzales L, Huemmelink R, Wilson C, Gross I. Corticosteroid binding by fetal rat and rabbit lung in organ culture. The Journal Of Steroid Biochemistry And Molecular Biology 1984, 21: 117-126. PMID: 6482426, DOI: 10.1016/0022-4731(84)90371-6.Peer-Reviewed Original ResearchConceptsRabbit lungsFetal ratsDexamethasone binding capacityConcentrations of dexamethasoneFetal lung cellsHalf-maximal stimulationGlucocorticoid effectsPhosphatidylcholine synthesisActive glucocorticoidsCorticosteroid metabolismDexamethasone bindingGlucocorticoid actionReceptor concentrationRabbit fetusesReceptor capacityFetal developmentRat lungLungBinding capacityFemale rabbitsLung cellsDexamethasoneCholine incorporationPhysiologic activityPrior exposure
1983
Corticosteroid Stimulation of Phosphatidylcholine Synthesis in Cultured Fetal Rabbit Lung: Evidence for de Novo Protein Synthesis Mediated by Glucocorticoid Receptors*
GROSS I, BALLARD P, BALLARD R, JONES C, WILSON C. Corticosteroid Stimulation of Phosphatidylcholine Synthesis in Cultured Fetal Rabbit Lung: Evidence for de Novo Protein Synthesis Mediated by Glucocorticoid Receptors*. Endocrinology 1983, 112: 829-837. PMID: 6822213, DOI: 10.1210/endo-112-3-829.Peer-Reviewed Original Research
1982
Fetal lung in organ culture. IV. Supra-additive hormone interactions
Gross I, Wilson C. Fetal lung in organ culture. IV. Supra-additive hormone interactions. Journal Of Applied Physiology 1982, 52: 1420-1425. PMID: 6286561, DOI: 10.1152/jappl.1982.52.6.1420.Peer-Reviewed Original ResearchConceptsFetal lung maturationLung maturationSupra-additive interactionOrgan cultureCombination of dexamethasoneRate of incorporationFetal rat lungVivo animal studiesHormone administrationFetal lungAnimal studiesRat lungSupra-additive stimulationThyroid hormonesNM dexamethasoneDexamethasone concentrationsMaximal stimulationLungDexamethasoneNM triiodothyroninePulmonary surfactantSignificant increaseStimulationPrecursor incorporationCyclic monophosphate
1980
Insulin antagonism of dexamethasone-induced stimulation of cholinephosphate cytidylyltransferase in fetal rat lung in organ culture
Rooney S, Ingleson L, Wilson C, Gross I. Insulin antagonism of dexamethasone-induced stimulation of cholinephosphate cytidylyltransferase in fetal rat lung in organ culture. Lung 1980, 158: 151-155. PMID: 6255261, DOI: 10.1007/bf02713717.Peer-Reviewed Original ResearchThe Influence of Hormones on the Biochemical Development of Fetal Rat Lung in Organ Culture. II. Insulin
Gross I, Walker Smith G, Wilson C, Maniscalco W, Ingleson L, Brehier A, Rooney S. The Influence of Hormones on the Biochemical Development of Fetal Rat Lung in Organ Culture. II. Insulin. Pediatric Research 1980, 14: 834-838. PMID: 6995921, DOI: 10.1203/00006450-198006000-00012.Peer-Reviewed Original ResearchConceptsFetal rat lungRat lungCholine incorporationSignificant decreasePhospholipid fractionInfluence of insulinEffect of insulinInfluence of hormonesPercentage of radioactivityType II cellsLung cell growthLung cell differentiationLung maturationOrgan culture systemInsulin treatmentMorphologic evidencePhospholipid radioactivityInsulinMorphologic maturationSurfactant phospholipidsGlycogen contentII cellsOrgan cultureBiochemical developmentLamellar bodiesFetal lung in organ culture. III. Comparison of dexamethasone, thyroxine, and methylxanthines
Gross I, Wilson C, Ingleson L, Brehier A, Rooney S. Fetal lung in organ culture. III. Comparison of dexamethasone, thyroxine, and methylxanthines. Journal Of Applied Physiology 1980, 48: 872-877. PMID: 7451297, DOI: 10.1152/jappl.1980.48.5.872.Peer-Reviewed Original ResearchConceptsFetal lungComparison of dexamethasoneLung glycogen contentSurfactant-associated phospholipidsFetal rat lungPercentage of radioactivityRat lungAminophyllineCholine-containing phospholipidsThyroxineGlycogen contentCholine incorporationLungCaffeine treatmentSignificant decreaseOrgan cultureRate of incorporationSignificant increaseLysolecithin acyltransferaseExposure of explantsCholinephosphate cytidylyltransferaseDexamethasoneDifferent effectsMembrane phospholipidsMethylxanthines