1998
Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats
Jacobs H, Bogue C, Pinter E, Wilson C, Warshaw J, Gross I. Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats. Pediatric Research 1998, 44: 99-104. PMID: 9667378, DOI: 10.1203/00006450-199807000-00016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsButyratesButyric AcidDiabetes Mellitus, ExperimentalEmbryonic and Fetal DevelopmentFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxGestational AgeHistone Deacetylase InhibitorsLungOrgan Culture TechniquesPregnancyPregnancy in DiabeticsRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticConceptsLung developmentLung explantsSurfactant apoproteinExperimental animalsLung mRNA levelsElevated levelsEffect of diabetesFetal rat lung explantsLungs of fetusesRat lung explantsEffect of butyrateAntenatal exposureMaternal diabetesMetabolic abnormalitiesStreptozotocin treatmentLower incidenceNormal ratsDiabetesDexamethasoneLevel of expressionRatsTreatment of explantsSodium butyrateMRNA levelsAlters expression
1996
Retinoic acid increases surfactant protein mRNA in fetal rat lung in culture
Bogue CW, Jacobs HC, Dynia DW, Wilson CM, Gross I. Retinoic acid increases surfactant protein mRNA in fetal rat lung in culture. American Journal Of Physiology 1996, 271: l862-l868. PMID: 8944731, DOI: 10.1152/ajplung.1996.271.5.l862.Peer-Reviewed Original Research
1994
Butyrate modulates surfactant protein mRNA in fetal rat lung by altering mRNA transcription and stability
Peterec S, Nichols K, Dynia D, Wilson C, Gross I. Butyrate modulates surfactant protein mRNA in fetal rat lung by altering mRNA transcription and stability. American Journal Of Physiology 1994, 267: l9-l15. PMID: 8048547, DOI: 10.1152/ajplung.1994.267.1.l9.Peer-Reviewed Original ResearchConceptsFetal rat lungButyric acid analogueMRNA concentrationsRat lungNa-butyrateSP-A levelsDiabetic pregnanciesMaternal diabetesPulmonary maturationLung maturationMRNA transcriptionBiphasic effectSurfactant protein mRNAsProtein mRNASP-B mRNAAcid analoguesButyrate treatmentLungExposure of explantsFetusesInitial decreaseMRNAGene expressionButyrateMaturationIdentification of Hox genes in newborn lung and effects of gestational age and retinoic acid on their expression
Bogue CW, Gross I, Vasavada H, Dynia DW, Wilson CM, Jacobs HC. Identification of Hox genes in newborn lung and effects of gestational age and retinoic acid on their expression. American Journal Of Physiology 1994, 266: l448-l454. PMID: 7909996, DOI: 10.1152/ajplung.1994.266.4.l448.Peer-Reviewed Original ResearchConceptsGestational ageReverse transcription-polymerase chain reactionNewborn mouse lungRat lung explantsMouse lungRetinoic acidMRNA levelsLung explantsRat lungFetal rat lung explantsEffects of RATranscription-polymerase chain reactionM retinoic acidTime-dependent increaseNewborn lungRA treatmentFetal miceLungRodent lungsSignificant doseHigher mRNA levelsFetal tissuesDivergent homeobox gene HexGene expressionPattern of expression
1992
Surfactant protein C: hormonal control of SP-C mRNA levels in vitro
Veletza S, Nichols K, Gross I, Lu H, Dynia D, Floros J. Surfactant protein C: hormonal control of SP-C mRNA levels in vitro. American Journal Of Physiology 1992, 262: l684-l687. PMID: 1319687, DOI: 10.1152/ajplung.1992.262.6.l684.Peer-Reviewed Original ResearchMeSH Keywords8-Bromo Cyclic Adenosine MonophosphateAnalysis of VarianceAnimalsBase SequenceBucladesineCell NucleusCloning, MolecularDexamethasoneFetusGene LibraryHumansKineticsLungMolecular Sequence DataOligonucleotide ProbesOrgan Culture TechniquesProteolipidsPulmonary SurfactantsRatsRNA, MessengerTranscription, GeneticConceptsSP-C mRNA levelsSP-C mRNAMRNA levelsHormonal regulationSurfactant protein CSurfactant protein mRNAsTranscriptional assaysThyroid hormone T3Transcriptional stepNorthern blotCDNA probeProtein mRNACyclic monophosphateCAMP analogSpHormone T3Hormonal controlMRNASurfactant proteinsRegulationLung explantsDose-dependent increaseRat lung explantsExplantsProtein C