1988
Prevention of respiratory distress syndrome.
Moya F, Gross I. Prevention of respiratory distress syndrome. Seminars In Perinatology 1988, 12: 348-58. PMID: 3146813.Chapters
1984
Corticosteroid binding by fetal rat and rabbit lung in organ culture
Ballard P, Ballard R, Gonzales L, Huemmelink R, Wilson C, Gross I. Corticosteroid binding by fetal rat and rabbit lung in organ culture. The Journal Of Steroid Biochemistry And Molecular Biology 1984, 21: 117-126. PMID: 6482426, DOI: 10.1016/0022-4731(84)90371-6.Peer-Reviewed Original ResearchConceptsRabbit lungsFetal ratsDexamethasone binding capacityConcentrations of dexamethasoneFetal lung cellsHalf-maximal stimulationGlucocorticoid effectsPhosphatidylcholine synthesisActive glucocorticoidsCorticosteroid metabolismDexamethasone bindingGlucocorticoid actionReceptor concentrationRabbit fetusesReceptor capacityFetal developmentRat lungLungBinding capacityFemale rabbitsLung cellsDexamethasoneCholine incorporationPhysiologic activityPrior exposure
1983
Corticosteroid Stimulation of Phosphatidylcholine Synthesis in Cultured Fetal Rabbit Lung: Evidence for de Novo Protein Synthesis Mediated by Glucocorticoid Receptors*
GROSS I, BALLARD P, BALLARD R, JONES C, WILSON C. Corticosteroid Stimulation of Phosphatidylcholine Synthesis in Cultured Fetal Rabbit Lung: Evidence for de Novo Protein Synthesis Mediated by Glucocorticoid Receptors*. Endocrinology 1983, 112: 829-837. PMID: 6822213, DOI: 10.1210/endo-112-3-829.Peer-Reviewed Original Research
1979
The Hormonal Regulation of Fetal Lung Maturation
Gross I. The Hormonal Regulation of Fetal Lung Maturation. Clinics In Perinatology 1979, 6: 377-395. PMID: 230006, DOI: 10.1016/s0095-5108(18)31155-2.ChaptersThyrotropin-Releasing Hormone Increases the Amount of Surfactant in Lung Lavage from Fetal Rabbits
Rooney S, Marino P, Gobran L, Gross I, Warshaw J. Thyrotropin-Releasing Hormone Increases the Amount of Surfactant in Lung Lavage from Fetal Rabbits. Pediatric Research 1979, 13: 623-625. PMID: 112569, DOI: 10.1203/00006450-197905000-00009.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneLung lavageLung maturationFetal lung slicesRespiratory distress syndromeFetal lung maturationPulmonary surfactant productionSurfactant productionPhosphatidylcholine/sphingomyelin ratioDistress syndromeTRH administrationPregnant rabbitsIncorporation of cholineFetal rabbitsGestation resultsLung slicesLavagePhysiologic roleFetusesSphingomyelin ratioTotal phospholipidsControl littersSurfactant releasePhospholipid contentMore phosphatidylcholineEffects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung
Rooney S, Gobran L, Marino P, Maniscalco W, Gross I. Effects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung. Biochimica Et Biophysica Acta 1979, 572: 64-76. PMID: 216408, DOI: 10.1016/0005-2760(79)90200-5.Peer-Reviewed Original ResearchConceptsLung lavageFetal lung lavageFetal lung slicesAdministration of betamethasoneEffect of betamethasoneFetal lung maturationFetal rabbit lungPhosphatidylcholine/sphingomyelin ratioLung glycogenBetamethasone administrationLung maturationPregnant rabbitsDays gestationFetal lungLung slicesRabbit lungsStress-induced accelerationDirect administrationSphingomyelin ratioSurfactant phospholipidsBetamethasoneAdministrationRate of incorporationSurfactant productionLavage
1978
Phosphatidylcholine synthesis in newborn rabbit lung developmental pattern and the influence of nutrition
Gross I, Wilson C, Rooney S. Phosphatidylcholine synthesis in newborn rabbit lung developmental pattern and the influence of nutrition. Biochimica Et Biophysica Acta 1978, 528: 190-198. PMID: 623776, DOI: 10.1016/0005-2760(78)90193-5.Peer-Reviewed Original ResearchConceptsLung lavage
1976
Studies on pulmonary surfactant Effects of cortisol administration to fetal rabbits on lung phospholipid content, composition and biosynthesis
Rooney S, Gobran L, Gross I, Wai-Lee T, Nardone L, Motoyama E. Studies on pulmonary surfactant Effects of cortisol administration to fetal rabbits on lung phospholipid content, composition and biosynthesis. Biochimica Et Biophysica Acta 1976, 450: 121-130. PMID: 186118, DOI: 10.1016/0005-2760(76)90083-7.Peer-Reviewed Original ResearchMeSH Keywords1-Acylglycerophosphocholine O-AcyltransferaseAnimalsCholine KinaseCytidine Diphosphate CholineDiacylglycerol CholinephosphotransferaseFatty AcidsFemaleFetusGestational AgeGlycerolHydrocortisoneLungNucleotidyltransferasesPhosphatidylcholinesPhospholipidsPregnancyPulmonary SurfactantsRabbitsConceptsLung lavageCortisol administrationDays gestationFetal rabbitsUntreated fetusesLung phospholipid contentGreater gestational ageSaline-injected controlsLysolecithin acyltransferasePhospholipid contentGestational ageIntrauterine injectionLung tissueSaline injectionFetal lungMaturational effectsGestationFetusesLavageMajor surface-active componentAdministrationCorticosteroidsCholinephosphate cytidylyltransferaseSynthesis of phosphatidylcholineHormone
1975
Stimulation of glycerolphosphate phosphatidyltransferase activity in fetal rabbit lung by cortisol administration
Rooney S, Gross I, Gassenheimer L, Motoyama E. Stimulation of glycerolphosphate phosphatidyltransferase activity in fetal rabbit lung by cortisol administration. Biochimica Et Biophysica Acta 1975, 398: 433-441. PMID: 1242106, DOI: 10.1016/0005-2760(75)90194-0.Peer-Reviewed Original ResearchConceptsAdministration of cortisolFetal rabbit lungLysolecithin acyltransferase activityLung maturationLiver enzymesDays gestationFetal rabbitsThyroxine treatmentGestation resultsCortisol administrationRabbit lungsCortisol treatmentDirect administrationAdministrationPulmonary surfactantSurfactant productionSignificant increaseGestationCholine phosphotransferaseAcyltransferase activityTreatmentCorticosteroidsPrevious studiesLungFetusesThe Influence of Cortisol on the Enzymes of Fatty Acid Synthesis in Developing Mammalian Lung and Brain
Gross I, Rooney S, Warshaw J. The Influence of Cortisol on the Enzymes of Fatty Acid Synthesis in Developing Mammalian Lung and Brain. Pediatric Research 1975, 9: 752-755. PMID: 648, DOI: 10.1203/00006450-197509000-00014.Peer-Reviewed Original ResearchConceptsDe novo fatty acid synthesisNovo fatty acid synthesisFatty acid synthesisRabbit lungsFatty acid synthetaseAcetyl-CoA carboxylase activityAccelerated lung maturationCortisol-induced inhibitionHyaline membrane diseaseAdministration of cortisolFetal rabbit lungInfluence of cortisolFatty acid synthetase activityAcid synthesisFatty acid elongation activityAntenatal administrationNumber of inhibitoryMembrane diseaseRight lungLung maturationLung growthCortisol exposureElectron microscopic examinationFetal rabbitsFetal brain
1974
Enzyme Activities Related to Fatty Acid Synthesis in Developing Mammalian Lung
Gross I, Warshaw J. Enzyme Activities Related to Fatty Acid Synthesis in Developing Mammalian Lung. Pediatric Research 1974, 8: 193-199. PMID: 4150151, DOI: 10.1203/00006450-197403000-00007.Peer-Reviewed Original ResearchConceptsDe novo fatty acid synthesisNovo fatty acid synthesisFetal lifeFatty acid synthesisRabbit lungsHepatic de novo fatty acid synthesisEarly dietary intakeHepatic fatty acid synthesisFatty acidsFetal rabbit lungAcid synthesisDe novo pathwaySurface-active lipidsPulmonary synthesisFatty acid elongationLung homogenatesDietary intakeNutritional intakeFetal rabbitsMicrosomal fatty acid elongationRabbit fetusesLipid metabolismLung membranesLungAdult levels