1983
Lung surfactant in the hyperinsulinemic fetal monkey
Rooney S, Chu A, Gross I, Marino P, Schwartz R, Seghal P, Singer D, Susa J, Warshaw J, Wilson C. Lung surfactant in the hyperinsulinemic fetal monkey. Lung 1983, 161: 313-317. PMID: 6355669, DOI: 10.1007/bf02713877.Peer-Reviewed Original ResearchConceptsAbsence of hyperglycemiaBlood insulin levelsFetal rhesus monkeysEffect of hyperinsulinemiaInfusion of insulinSurfactant productionLung surfactant productionDiabetic mothersAlzet minipumpsInsulin levelsD gestationFetal monkeysFetal primateLung lavageLung tissueDays gestationLung slicesBody weightControl groupRhesus monkeysHyperinsulinemiaGestationCholine incorporationInhibitory effectHuman infants
1979
Thyrotropin-Releasing Hormone Increases the Amount of Surfactant in Lung Lavage from Fetal Rabbits
Rooney S, Marino P, Gobran L, Gross I, Warshaw J. Thyrotropin-Releasing Hormone Increases the Amount of Surfactant in Lung Lavage from Fetal Rabbits. Pediatric Research 1979, 13: 623-625. PMID: 112569, DOI: 10.1203/00006450-197905000-00009.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneLung lavageLung maturationFetal lung slicesRespiratory distress syndromeFetal lung maturationPulmonary surfactant productionSurfactant productionPhosphatidylcholine/sphingomyelin ratioDistress syndromeTRH administrationPregnant rabbitsIncorporation of cholineFetal rabbitsGestation resultsLung slicesLavagePhysiologic roleFetusesSphingomyelin ratioTotal phospholipidsControl littersSurfactant releasePhospholipid contentMore phosphatidylcholineEffects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung
Rooney S, Gobran L, Marino P, Maniscalco W, Gross I. Effects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung. Biochimica Et Biophysica Acta 1979, 572: 64-76. PMID: 216408, DOI: 10.1016/0005-2760(79)90200-5.Peer-Reviewed Original ResearchConceptsLung lavageFetal lung lavageFetal lung slicesAdministration of betamethasoneEffect of betamethasoneFetal lung maturationFetal rabbit lungPhosphatidylcholine/sphingomyelin ratioLung glycogenBetamethasone administrationLung maturationPregnant rabbitsDays gestationFetal lungLung slicesRabbit lungsStress-induced accelerationDirect administrationSphingomyelin ratioSurfactant phospholipidsBetamethasoneAdministrationRate of incorporationSurfactant productionLavage
1978
Phosphatidylcholine synthesis in newborn rabbit lung developmental pattern and the influence of nutrition
Gross I, Wilson C, Rooney S. Phosphatidylcholine synthesis in newborn rabbit lung developmental pattern and the influence of nutrition. Biochimica Et Biophysica Acta 1978, 528: 190-198. PMID: 623776, DOI: 10.1016/0005-2760(78)90193-5.Peer-Reviewed Original ResearchConceptsLung lavage
1976
Studies on pulmonary surfactant Effects of cortisol administration to fetal rabbits on lung phospholipid content, composition and biosynthesis
Rooney S, Gobran L, Gross I, Wai-Lee T, Nardone L, Motoyama E. Studies on pulmonary surfactant Effects of cortisol administration to fetal rabbits on lung phospholipid content, composition and biosynthesis. Biochimica Et Biophysica Acta 1976, 450: 121-130. PMID: 186118, DOI: 10.1016/0005-2760(76)90083-7.Peer-Reviewed Original ResearchMeSH Keywords1-Acylglycerophosphocholine O-AcyltransferaseAnimalsCholine KinaseCytidine Diphosphate CholineDiacylglycerol CholinephosphotransferaseFatty AcidsFemaleFetusGestational AgeGlycerolHydrocortisoneLungNucleotidyltransferasesPhosphatidylcholinesPhospholipidsPregnancyPulmonary SurfactantsRabbitsConceptsLung lavageCortisol administrationDays gestationFetal rabbitsUntreated fetusesLung phospholipid contentGreater gestational ageSaline-injected controlsLysolecithin acyltransferasePhospholipid contentGestational ageIntrauterine injectionLung tissueSaline injectionFetal lungMaturational effectsGestationFetusesLavageMajor surface-active componentAdministrationCorticosteroidsCholinephosphate cytidylyltransferaseSynthesis of phosphatidylcholineHormoneThe influence of postnatal nutritional deprivation on the phospholipid content of developing rat lung
Gross I, Ilic I, Wilson C, Rooney S. The influence of postnatal nutritional deprivation on the phospholipid content of developing rat lung. Biochimica Et Biophysica Acta 1976, 441: 412-422. PMID: 9987, DOI: 10.1016/0005-2760(76)90238-1.Peer-Reviewed Original ResearchConceptsLung cell numberLung lavage phospholipidPostnatal nutritional deprivationTotal phospholipidsStandard rat chowLung protein contentPhosphatidylcholine contentRole of nutritionLung phospholipid synthesisFat-fed animalsLung surfactant productionLavage phospholipidsGlucose-fed groupRat chowLung lavageLung tissueDietary regimensMicrosomal fatty acid elongationRat lungLung proteinFasted animalsProtein dietLungNutritional deprivationAcetyl-CoA carboxylase