1994
Butyrate modulates surfactant protein mRNA in fetal rat lung by altering mRNA transcription and stability
Peterec S, Nichols K, Dynia D, Wilson C, Gross I. Butyrate modulates surfactant protein mRNA in fetal rat lung by altering mRNA transcription and stability. American Journal Of Physiology 1994, 267: l9-l15. PMID: 8048547, DOI: 10.1152/ajplung.1994.267.1.l9.Peer-Reviewed Original ResearchConceptsFetal rat lungButyric acid analogueMRNA concentrationsRat lungNa-butyrateSP-A levelsDiabetic pregnanciesMaternal diabetesPulmonary maturationLung maturationMRNA transcriptionBiphasic effectSurfactant protein mRNAsProtein mRNASP-B mRNAAcid analoguesButyrate treatmentLungExposure of explantsFetusesInitial decreaseMRNAGene expressionButyrateMaturationIdentification of Hox genes in newborn lung and effects of gestational age and retinoic acid on their expression
Bogue CW, Gross I, Vasavada H, Dynia DW, Wilson CM, Jacobs HC. Identification of Hox genes in newborn lung and effects of gestational age and retinoic acid on their expression. American Journal Of Physiology 1994, 266: l448-l454. PMID: 7909996, DOI: 10.1152/ajplung.1994.266.4.l448.Peer-Reviewed Original ResearchConceptsGestational ageReverse transcription-polymerase chain reactionNewborn mouse lungRat lung explantsMouse lungRetinoic acidMRNA levelsLung explantsRat lungFetal rat lung explantsEffects of RATranscription-polymerase chain reactionM retinoic acidTime-dependent increaseNewborn lungRA treatmentFetal miceLungRodent lungsSignificant doseHigher mRNA levelsFetal tissuesDivergent homeobox gene HexGene expressionPattern of expression
1989
Initiation of Fetal Rat Lung Phospholipid and Surfactant-Associated Protein A mRNA Synthesis
Gross I, Wilson C, Floros J, Dynia D. Initiation of Fetal Rat Lung Phospholipid and Surfactant-Associated Protein A mRNA Synthesis. Pediatric Research 1989, 25: 239-244. PMID: 2704589, DOI: 10.1203/00006450-198903000-00004.Peer-Reviewed Original ResearchConceptsRU 486Lung tissueGlucocorticoid agonist activityRat lung phospholipidsAntagonist RU 486Steroid antagonist RU 486Surfactant-associated protein AFetal rat lungGlucocorticoid antagonistSurfactant associated proteinsLung phospholipidsSurfactant-associated proteinsFetal lungRat lungSurfactant productionComponents of surfactantSignificant increaseGlucocorticoidsLungControl explantsSpecific cytoplasmicPhosphatidylcholine synthesisSame extentPhospholipid productionTissue
1987
The Biochemistry of Fetal Lung Development
Kresch M, Gross I. The Biochemistry of Fetal Lung Development. Clinics In Perinatology 1987, 14: 481-507. PMID: 3311536, DOI: 10.1016/s0095-5108(18)30747-4.ChaptersConceptsSurfactant therapyLung complianceLung maturationAdministration of betamethasoneEffects of glucocorticoidsFetal lung developmentNumber of alveoliGlucocorticoid therapyFetal rabbitsLung developmentTherapyAnimal dataTissue complianceHormonal enhancementAdditive effectAdministrationComplianceMaturationRDSMorbidityBetamethasoneGlucocorticoidsLungMortalitySteroids
1984
Corticosteroid binding by fetal rat and rabbit lung in organ culture
Ballard P, Ballard R, Gonzales L, Huemmelink R, Wilson C, Gross I. Corticosteroid binding by fetal rat and rabbit lung in organ culture. The Journal Of Steroid Biochemistry And Molecular Biology 1984, 21: 117-126. PMID: 6482426, DOI: 10.1016/0022-4731(84)90371-6.Peer-Reviewed Original ResearchConceptsRabbit lungsFetal ratsDexamethasone binding capacityConcentrations of dexamethasoneFetal lung cellsHalf-maximal stimulationGlucocorticoid effectsPhosphatidylcholine synthesisActive glucocorticoidsCorticosteroid metabolismDexamethasone bindingGlucocorticoid actionReceptor concentrationRabbit fetusesReceptor capacityFetal developmentRat lungLungBinding capacityFemale rabbitsLung cellsDexamethasoneCholine incorporationPhysiologic activityPrior exposureDO EGF AND GLUCOCORTICOIDS ACT AT THE SAME METABOLIC SITES IN FETAL RAT LUNG?
Gross I, Dynia D. DO EGF AND GLUCOCORTICOIDS ACT AT THE SAME METABOLIC SITES IN FETAL RAT LUNG? Pediatric Research 1984, 18: 392-392. DOI: 10.1203/00006450-198404001-01797.Peer-Reviewed Original ResearchFetal rat lungCholine incorporationEffect of EGFRat lungFetal lung maturationEffect of DexDose-dependent fashionMetabolic sitesGestational ageLung maturationOrgan culture systemFetal lungGlucocorticoids actSerum-free organ culture systemMaximal effectDistribution of radioactivityThymidine incorporationMouse skinLungDependent fashionBiochemical developmentPhosphatidylglycerol fractionT3T4 actionEGF
1983
Fetal rat lung maturation: initiation and modulation
Gross I, Wilson C. Fetal rat lung maturation: initiation and modulation. Journal Of Applied Physiology 1983, 55: 1725-1732. PMID: 6662763, DOI: 10.1152/jappl.1983.55.6.1725.Peer-Reviewed Original ResearchConceptsFetal lung maturationGestational ageLung maturationCholine incorporationEquivalent gestational ageFetal rat lungGlucocorticoid bindingDays gestationLung tissueFetal lungRat lungBiochemical markersLung developmentMorphological maturationDSPC contentMesenchymal tissueMaturational processesMarked increaseHormoneSimilar increaseLungLate modulationPhosphatidylcholine synthesisAgeMaturation
1982
Fetal lung in organ culture. IV. Supra-additive hormone interactions
Gross I, Wilson C. Fetal lung in organ culture. IV. Supra-additive hormone interactions. Journal Of Applied Physiology 1982, 52: 1420-1425. PMID: 6286561, DOI: 10.1152/jappl.1982.52.6.1420.Peer-Reviewed Original ResearchConceptsFetal lung maturationLung maturationSupra-additive interactionOrgan cultureCombination of dexamethasoneRate of incorporationFetal rat lungVivo animal studiesHormone administrationFetal lungAnimal studiesRat lungSupra-additive stimulationThyroid hormonesNM dexamethasoneDexamethasone concentrationsMaximal stimulationLungDexamethasoneNM triiodothyroninePulmonary surfactantSignificant increaseStimulationPrecursor incorporationCyclic monophosphate
1981
Organotypic Culture of Fetal Rat Lung: Evaluation and Comparison with Organ Culture1–3
Gross I, Freedman R, Wilson C, Lindsey S. Organotypic Culture of Fetal Rat Lung: Evaluation and Comparison with Organ Culture1–3. American Journal Of Respiratory And Critical Care Medicine 1981, 123: 313-9. PMID: 7224342, DOI: 10.1164/arrd.1981.123.3.313.Peer-Reviewed Original Research
1980
Insulin antagonism of dexamethasone-induced stimulation of cholinephosphate cytidylyltransferase in fetal rat lung in organ culture
Rooney S, Ingleson L, Wilson C, Gross I. Insulin antagonism of dexamethasone-induced stimulation of cholinephosphate cytidylyltransferase in fetal rat lung in organ culture. Lung 1980, 158: 151-155. PMID: 6255261, DOI: 10.1007/bf02713717.Peer-Reviewed Original ResearchFetal lung in organ culture. III. Comparison of dexamethasone, thyroxine, and methylxanthines
Gross I, Wilson C, Ingleson L, Brehier A, Rooney S. Fetal lung in organ culture. III. Comparison of dexamethasone, thyroxine, and methylxanthines. Journal Of Applied Physiology 1980, 48: 872-877. PMID: 7451297, DOI: 10.1152/jappl.1980.48.5.872.Peer-Reviewed Original ResearchConceptsFetal lungComparison of dexamethasoneLung glycogen contentSurfactant-associated phospholipidsFetal rat lungPercentage of radioactivityRat lungAminophyllineCholine-containing phospholipidsThyroxineGlycogen contentCholine incorporationLungCaffeine treatmentSignificant decreaseOrgan cultureRate of incorporationSignificant increaseLysolecithin acyltransferaseExposure of explantsCholinephosphate cytidylyltransferaseDexamethasoneDifferent effectsMembrane phospholipidsMethylxanthines
1979
The influence of hormones on the biochemical development of fetal rat lung in organ culture I. Estrogen
Gross I, Wilson C, Ingleson L, Brehier A, Rooney S. The influence of hormones on the biochemical development of fetal rat lung in organ culture I. Estrogen. Biochimica Et Biophysica Acta 1979, 575: 375-383. PMID: 518894, DOI: 10.1016/0005-2760(79)90106-1.Peer-Reviewed Original ResearchConceptsFetal rat lungPercentage of radioactivityEstrogen actsFetal lungRat lungPhospholipid fractionInfluence of hormonesProtein/DNA ratioEstrogen treatmentIncorporation of cholineLungGlycogen contentTotal phospholipidsOrgan cultureSignificant stimulationPulmonary surfactantBiochemical developmentIndividual phospholipidsPhosphatidylcholine synthesisSignificant changesPhospholipid synthesisPhospholipidsAbundant phospholipidDNA ratioRadioactivityInfluence of Aminophylline and Cyclic AMP on Glycogen Metabolism in Fetal Rat Lung in Organ Culture
Maniscalco W, Wilson C, Gross I. Influence of Aminophylline and Cyclic AMP on Glycogen Metabolism in Fetal Rat Lung in Organ Culture. Pediatric Research 1979, 13: 1319-1322. PMID: 230447, DOI: 10.1203/00006450-197912000-00003.Peer-Reviewed Original ResearchConceptsFetal rat lungRat lungCyclic AMPFetal pulmonary surfactantInfluence of aminophyllineEffect of aminophyllineGlycogen synthase I activityOrgan cultureLung phospholipid synthesisGlycogen metabolismTotal phosphorylase activityDibutyryl cyclic AMPMonophosphate phosphodiesterase inhibitorSynthase I activityPhospholipid synthesisAminophyllinePhosphodiesterase inhibitorGlycogen contentLungGlycogen breakdownCyclic AMP treatmentAMP treatmentPulmonary surfactantAMPPhosphorylase activityThe Hormonal Regulation of Fetal Lung Maturation
Gross I. The Hormonal Regulation of Fetal Lung Maturation. Clinics In Perinatology 1979, 6: 377-395. PMID: 230006, DOI: 10.1016/s0095-5108(18)31155-2.Chapters
1978
Development of glycogen and phospholipid metabolism in fetal and newborn rat lung
Maniscalco W, Wilson C, Gross I, Gobran L, Rooney S, Warshaw J. Development of glycogen and phospholipid metabolism in fetal and newborn rat lung. Biochimica Et Biophysica Acta 1978, 530: 333-346. PMID: 100141, DOI: 10.1016/0005-2760(78)90153-4.Peer-Reviewed Original ResearchConceptsNewborn rat lungGlycogen phosphorylase activityFetal lungRat lungGlycogen concentrationFetal lung glycogenFirst postnatal dayPhosphorylase activityTotal glycogen synthaseTotal glycogen phosphorylase activityMajor metabolic substratesLung glycogenPhosphatidylcholine synthesisGlycogen synthase activityIncorporation of cholinePostnatal dayGlycogen depletionDay 19LungGestationDay 20Adult lungMammalian fetusGlycogen contentTotal phospholipids
1977
Aminophylline stimulates the incorporation of choline into phospholipid in explants of fetal rat lung in organ culture
Gross I, Rooney S. Aminophylline stimulates the incorporation of choline into phospholipid in explants of fetal rat lung in organ culture. Biochimica Et Biophysica Acta 1977, 488: 263-269. PMID: 196659, DOI: 10.1016/0005-2760(77)90183-7.Peer-Reviewed Original ResearchConceptsFetal rat lungRat lungCholine incorporationIncorporation of cholineCyclic AMPCyclic AMP phosphodiesterase inhibitorDirect stimulatory effectOrgan cultureF12 mediumAminophylline treatmentDibutyryl cyclic AMPMM aminophyllinePhosphodiesterase inhibitorAminophyllineLungStimulatory effectSimilar changesAMPStimulationDirect effectSmall increaseCholine kinaseCholineExposurePhospholipidsAMINOPHYLLINE STIMULATES PHOSPHOLIPID SYNTHESIS BY FETAL RAT LUNG IN ORGAN CULTURE
Gross I, Rooney S, Warshaw J. AMINOPHYLLINE STIMULATES PHOSPHOLIPID SYNTHESIS BY FETAL RAT LUNG IN ORGAN CULTURE. Pediatric Research 1977, 11: 571-571. DOI: 10.1203/00006450-197704000-01210.Peer-Reviewed Original ResearchFetal rat lungRat lungInfluence of aminophyllineAdministration of aminophyllineOrgan cultureLung phospholipid synthesisCyclic AMPAminophylline effectsDays lungsDibutyryl cyclic AMPNonspecific stimulationLES stimulationIncorporation of cholineMM aminophyllineFetal rabbitsPhospholipid synthesisAminophyllineProtein/hourLungDay fetusesSignificant increaseF12 mediumSph synthesisStimulationExposureINSULIN DELAYS THE MORPHOLOGIC MATURATION OF FETAL RAT LUNG IN VITRO
Gross I, Walker Smith G, Warshaw J. INSULIN DELAYS THE MORPHOLOGIC MATURATION OF FETAL RAT LUNG IN VITRO. Pediatric Research 1977, 11: 515-515. DOI: 10.1203/00006450-197704000-00871.Peer-Reviewed Original ResearchAlveolar lining cellsLining cellsFetal rat lungAlveolar spaceLamellar bodiesRat lungGlycogen contentLevels of insulinIncidence of RDSInfluence of insulinControl culturesF12 mediumDiabetic mothersLung maturationFetal lungInsulinMorphologic maturationInterstitial tissueLungOrgan cultureGlycogen synthesisInterstitial mesenchymeContinued maturationMorphologic developmentCells
1976
The influence of postnatal nutritional deprivation on the phospholipid content of developing rat lung
Gross I, Ilic I, Wilson C, Rooney S. The influence of postnatal nutritional deprivation on the phospholipid content of developing rat lung. Biochimica Et Biophysica Acta 1976, 441: 412-422. PMID: 9987, DOI: 10.1016/0005-2760(76)90238-1.Peer-Reviewed Original ResearchConceptsLung cell numberLung lavage phospholipidPostnatal nutritional deprivationTotal phospholipidsStandard rat chowLung protein contentPhosphatidylcholine contentRole of nutritionLung phospholipid synthesisFat-fed animalsLung surfactant productionLavage phospholipidsGlucose-fed groupRat chowLung lavageLung tissueDietary regimensMicrosomal fatty acid elongationRat lungLung proteinFasted animalsProtein dietLungNutritional deprivationAcetyl-CoA carboxylase
1975
Stimulation of glycerolphosphate phosphatidyltransferase activity in fetal rabbit lung by cortisol administration
Rooney S, Gross I, Gassenheimer L, Motoyama E. Stimulation of glycerolphosphate phosphatidyltransferase activity in fetal rabbit lung by cortisol administration. Biochimica Et Biophysica Acta 1975, 398: 433-441. PMID: 1242106, DOI: 10.1016/0005-2760(75)90194-0.Peer-Reviewed Original ResearchConceptsAdministration of cortisolFetal rabbit lungLysolecithin acyltransferase activityLung maturationLiver enzymesDays gestationFetal rabbitsThyroxine treatmentGestation resultsCortisol administrationRabbit lungsCortisol treatmentDirect administrationAdministrationPulmonary surfactantSurfactant productionSignificant increaseGestationCholine phosphotransferaseAcyltransferase activityTreatmentCorticosteroidsPrevious studiesLungFetuses