Butyrate modulates surfactant protein mRNA in fetal rat lung by altering mRNA transcription and stability
Peterec S, Nichols K, Dynia D, Wilson C, Gross I. Butyrate modulates surfactant protein mRNA in fetal rat lung by altering mRNA transcription and stability. American Journal Of Physiology 1994, 267: l9-l15. PMID: 8048547, DOI: 10.1152/ajplung.1994.267.1.l9.Peer-Reviewed Original ResearchConceptsFetal rat lungButyric acid analogueMRNA concentrationsRat lungNa-butyrateSP-A levelsDiabetic pregnanciesMaternal diabetesPulmonary maturationLung maturationMRNA transcriptionBiphasic effectSurfactant protein mRNAsProtein mRNASP-B mRNAAcid analoguesButyrate treatmentLungExposure of explantsFetusesInitial decreaseMRNAGene expressionButyrateMaturationIdentification of Hox genes in newborn lung and effects of gestational age and retinoic acid on their expression
Bogue CW, Gross I, Vasavada H, Dynia DW, Wilson CM, Jacobs HC. Identification of Hox genes in newborn lung and effects of gestational age and retinoic acid on their expression. American Journal Of Physiology 1994, 266: l448-l454. PMID: 7909996, DOI: 10.1152/ajplung.1994.266.4.l448.Peer-Reviewed Original ResearchConceptsGestational ageReverse transcription-polymerase chain reactionNewborn mouse lungRat lung explantsMouse lungRetinoic acidMRNA levelsLung explantsRat lungFetal rat lung explantsEffects of RATranscription-polymerase chain reactionM retinoic acidTime-dependent increaseNewborn lungRA treatmentFetal miceLungRodent lungsSignificant doseHigher mRNA levelsFetal tissuesDivergent homeobox gene HexGene expressionPattern of expression