2024
Loss of Katnal2 leads to ependymal ciliary hyperfunction and autism-related phenotypes in mice
Kang R, Kim K, Jung Y, Choi S, Lee C, Im G, Shin M, Ryu K, Choi S, Yang E, Shin W, Lee S, Lee S, Papadopoulos Z, Ahn J, Koh G, Kipnis J, Kang H, Kim H, Cho W, Park S, Kim S, Kim E. Loss of Katnal2 leads to ependymal ciliary hyperfunction and autism-related phenotypes in mice. PLOS Biology 2024, 22: e3002596. PMID: 38718086, PMCID: PMC11104772, DOI: 10.1371/journal.pbio.3002596.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderBehavioral phenotypesASD-relatedSocial communication deficitsAutism-related phenotypesEnlarged lateral ventriclesProgressive ventricular enlargementCommunication deficitsSpectrum disorderSynaptic deficitsEnlargement of brain ventriclesTranscriptomic changesMicrotubule-regulatory proteinsGenes down-regulatedBrain ventriclesVentricular enlargementLateral ventricleDeficitsHippocampal neuronsMotile ciliaKATNAL2Potential treatmentDown-regulationCiliary functionEpendymal cells
2014
Repeated treatment with electroconvulsive seizures induces HDAC2 expression and down-regulation of NMDA receptor-related genes through histone deacetylation in the rat frontal cortex
Park H, Yu H, Park S, Ahn Y, Kim Y, Kim H. Repeated treatment with electroconvulsive seizures induces HDAC2 expression and down-regulation of NMDA receptor-related genes through histone deacetylation in the rat frontal cortex. The International Journal Of Neuropsychopharmacology 2014, 17: 1487-1500. PMID: 24606669, DOI: 10.1017/s1461145714000248.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAnalysis of VarianceAnimalsButyric AcidChromatin ImmunoprecipitationDisease Models, AnimalElectroshockFrontal LobeGene Expression RegulationGlial Fibrillary Acidic ProteinHistamine AntagonistsHistone Deacetylase 2MalePhosphopyruvate HydrataseRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateRNA, MessengerSeizuresSignal TransductionConceptsSignaling-related genesHistone deacetylasesHistone modificationsHistone acetylationCalcium/calmodulin-dependent protein kinase II alphaChromatin immunoprecipitation analysisRat frontal cortexEarly growth response 1Transcriptional repressionReceptor-related genesHistone deacetylationH4 proteinN-methyl-D-aspartate 2ATarget genesFrontal cortexImmunoprecipitation analysisElectroconvulsive seizuresGene expressionResponse 1GenesHDAC2 expressionNeuronal cellsECS treatmentClass I HDACsII alpha
2006
Induction of Neuron-derived Orphan Receptor-1 in the Dentate Gyrus of the Hippocampal Formation Following Transient Global Ischemia in the Rat
Kim Y, Hong S, Noh M, Kim S, Huh P, Park S, Sun W, Kim H. Induction of Neuron-derived Orphan Receptor-1 in the Dentate Gyrus of the Hippocampal Formation Following Transient Global Ischemia in the Rat. Molecules And Cells 2006, 22: 8-12. PMID: 16951544, DOI: 10.1016/s1016-8478(23)17384-5.Peer-Reviewed Original ResearchConceptsTransient global ischemiaDentate gyrusGlobal ischemiaCultured cerebral cortical neuronsNOR-1Induction of neuronsCerebral cortical neuronsOxygen-glucose deprivationTransient ischemic injuryAdult rat brainForebrain neuronal cellsOrphan receptor 1Different brain regionsBrain ischemiaIschemic injuryCortical neuronsNeuronal depolarizationRat brainHippocampal formationReceptor 1Brain regionsSteroid receptorsIschemiaNeuronal cellsBasal levels