MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation
Papangeli I, Kim J, Maier I, Park S, Lee A, Kang Y, Tanaka K, Khan OF, Ju H, Kojima Y, Red-Horse K, Anderson DG, Siekmann AF, Chun HJ. MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation. Nature Communications 2016, 7: 11268. PMID: 27068353, PMCID: PMC4832062, DOI: 10.1038/ncomms11268.Peer-Reviewed Original ResearchConceptsRetinal vascular defectsMiR-139-5pG protein-coupled receptorsVascular defectsGPCR crosstalkProtein-coupled receptorsVascular developmentCXCR4 expressionCXCR4 axisCXCR4 signalingDownstream signaling cascadesVascular phenotypePharmacological inhibitionVascular maturationDeficient stateApelinAPLNRLigand-receptor pairsSignaling cascadesInhibitionCXCR4MiceReceptors