2007
Differential Cell-Specific Modulation of HOXA10 by Estrogen and Specificity Protein 1 Response Elements
Martin R, Taylor MB, Krikun G, Lockwood C, Akbas GE, Taylor HS. Differential Cell-Specific Modulation of HOXA10 by Estrogen and Specificity Protein 1 Response Elements. The Journal Of Clinical Endocrinology & Metabolism 2007, 92: 1920-1926. PMID: 17311863, DOI: 10.1210/jc.2006-1694.Peer-Reviewed Original ResearchMeSH KeywordsBreastCells, CulturedElectrophoretic Mobility Shift AssayEstrogensFemaleGenes, ReporterHomeobox A10 ProteinsHomeodomain ProteinsHumansImmunohistochemistryLuciferasesPlasmidsReceptors, EstrogenResponse ElementsReverse Transcriptase Polymerase Chain ReactionSp1 Transcription FactorTransfectionUterusConceptsEstrogen response elementHOXA10 estrogen response elementResponse elementSp1 sitesShift assaysStage-specific expression patternsTissue specificityElectrophoretic mobility shift assaysCell typesSpecificity protein 1Mobility shift assaysAdult reproductive tractGel shift assaysDifferential cellular expressionDistinct differential expressionHox genesSp1 proteinCell-specific modulationTranscription factorsEmbryonic developmentRegulatory elementsExpression patternsReporter assaysBreast MCF-7 cellsDifferential expression
2006
Xenoestrogen exposure imprints expression of genes (Hoxa10) required for normal uterine development
Smith CC, Taylor HS. Xenoestrogen exposure imprints expression of genes (Hoxa10) required for normal uterine development. The FASEB Journal 2006, 21: 239-246. PMID: 17093138, DOI: 10.1096/fj.06-6635com.Peer-Reviewed Original ResearchConceptsHOXA10 estrogen response elementEstrogen response elementHOXA10 expressionUterine developmentAbility of BPAReproductive tract alterationsUterine HOXA10 expressionUtero BPA exposureER antagonist ICIExpression of HOXA10Gestational day 9Normal uterine developmentDose-responsive increaseDose-response increaseHOXA10 mRNA expressionHOXA10 antisenseUtero exposureAntagonist ICITract alterationsBPA exposureIshikawa cellsBPA actionEstrogen stimulationEndocrine perturbationsDay 9