2023
A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking
Huang X, Miyata H, Wang H, Mori G, Iida-Norita R, Ikawa M, Percudani R, Chung J. A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2304409120. PMID: 37725640, PMCID: PMC10523455, DOI: 10.1073/pnas.2304409120.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MembraneIon ChannelsMaleMembrane ProteinsMiceSemenSeminal Plasma ProteinsSperm MotilitySperm TailSpermatozoaConceptsChannel assemblySperm flagellaTransmembrane domain-containing proteinsSperm tail formationDomain-containing proteinsCatSper channel complexMale fertilityFlagellar traffickingMacromolecular complexesTail formationPhysiological roleSuccessful fertilizationCalcium signalingCatSper channelsFlagellaGenetic abrogationChannel complexNormal expressionDimer formationSpermatid cellsProteinCheckpointHyperactivated motilityAssemblyPotential role
2013
Sperm-specific ion channels: targets holding the most potential for male contraceptives in development
Zheng L, Wang H, Li B, Zeng X. Sperm-specific ion channels: targets holding the most potential for male contraceptives in development. Contraception 2013, 88: 485-491. PMID: 23845210, DOI: 10.1016/j.contraception.2013.06.002.Peer-Reviewed Original ResearchMeSH KeywordsAnoctamin-1Calcium ChannelsChloride Channel AgonistsChloride ChannelsContraceptive Agents, MaleDrugs, InvestigationalHumansIon ChannelsLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsMaleMembrane ProteinsNeoplasm ProteinsOrgan SpecificityPotassium Channels, Voltage-GatedProtein SubunitsSignal TransductionSpermatozoa