2021
Physiologically detectable bisphenol A impairs human sperm functions by reducing protein-tyrosine phosphorylation
Li N, Kang H, Peng Z, Wang H, Weng S, Zeng X. Physiologically detectable bisphenol A impairs human sperm functions by reducing protein-tyrosine phosphorylation. Ecotoxicology And Environmental Safety 2021, 221: 112418. PMID: 34146982, DOI: 10.1016/j.ecoenv.2021.112418.Peer-Reviewed Original ResearchConceptsHuman sperm viabilityHuman sperm functionHuman spermExposure of BPASperm functionProgesterone-induced acrosome reactionProtein tyrosine phosphorylationProtein tyrosine phosphorylation levelsAcrosome reactionMale infertilityHealthy peopleMouse sperm motilitySperm viabilityCalcium signalingPhosphorylation levelsTyrosine phosphorylation levelsBisphenol ASperm motilityProgressive motilityHyperactivationMotilityDetectable concentrationRemarkable declineTyrosine phosphorylationPlastic monomers
2020
Sperm ion channels and transporters in male fertility and infertility
Wang H, McGoldrick LL, Chung JJ. Sperm ion channels and transporters in male fertility and infertility. Nature Reviews Urology 2020, 18: 46-66. PMID: 33214707, PMCID: PMC7852504, DOI: 10.1038/s41585-020-00390-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSperm ion channelsIon channelsSperm cellsMammalian sperm cellsIon signalingDynamic regulationDefective sperm functionFemale reproductive tractChannel CatSperHuman geneticsMembrane receptorsMale fertilityHealth careAttractive targetDirect electrophysiological recordingsOverall health careHuman infertilityReproductive health careSperm functionPrincipal Ca2Development of contraceptivesSperm activityGene variantsReproductive tractGenetic abnormalities
2019
A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters
Luo T, Chen H, Zou Q, Wang T, Cheng Y, Wang H, Wang F, Jin Z, Chen Y, Weng S, Zeng X. A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters. Human Reproduction 2019, 34: 414-423. PMID: 30629171, DOI: 10.1093/humrep/dey377.Peer-Reviewed Original ResearchConceptsIdiopathic male infertilityNormal semen parametersWhole-cell patch-clamp techniqueMale infertilityPatch-clamp techniqueSemen parametersCatSper currentsIdiopathic infertilitySTUDY FUNDING/COMPETINGGenetic abnormalitiesCatSper genesChild Health HospitalReproductive medical centerNovel copy number variationsPARTICIPANTS/MATERIALSROLE OF CHANCEHuman male infertilityHealthy male donorsCopy number variationsHuman CatSperPrinciple Ca2Progesterone responseCase reportProvincial MaternalHealth Hospital
2016
Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa
Zou Q, Peng Z, Zhao Q, Chen H, Cheng Y, Liu Q, He Y, Weng S, Wang H, Wang T, Zheng L, Luo T. Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa. Human Reproduction 2016, 32: 290-298. PMID: 28031325, DOI: 10.1093/humrep/dew332.Peer-Reviewed Original ResearchConceptsNon-genomic mannerProgesterone actionHuman sperm functionEndocrine-disrupting chemicalsSperm intracellular calcium concentrationsWhole-cell patch-clamp techniqueSperm functionHuman spermatozoaPARTICIPANTS/MATERIALSHuman sperm penetrationIndicator Fluo-4 AMIntracellular calcium concentrationROLE OF CHANCEAcrosome reactionEffects of diethylstilbestrolPatch-clamp techniqueFluo-4 AMFemale reproductive tract fluidsMale reproductive systemTyrosine phosphorylationReproductive tract fluidsDES exposurePostnatal exposureEstrogenic endocrine disruptorsAbility of sperm
2013
Sperm-specific ion channels: targets holding the most potential for male contraceptives in development
Zheng L, Wang H, Li B, Zeng X. Sperm-specific ion channels: targets holding the most potential for male contraceptives in development. Contraception 2013, 88: 485-491. PMID: 23845210, DOI: 10.1016/j.contraception.2013.06.002.Peer-Reviewed Original ResearchMeSH KeywordsAnoctamin-1Calcium ChannelsChloride Channel AgonistsChloride ChannelsContraceptive Agents, MaleDrugs, InvestigationalHumansIon ChannelsLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsMaleMembrane ProteinsNeoplasm ProteinsOrgan SpecificityPotassium Channels, Voltage-GatedProtein SubunitsSignal TransductionSpermatozoa