2022
C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane
Hwang JY, Wang H, Lu Y, Ikawa M, Chung JJ. C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane. Cell Reports 2022, 38: 110226. PMID: 34998468, PMCID: PMC8857959, DOI: 10.1016/j.celrep.2021.110226.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalcium ChannelsCalcium SignalingFlagellaMaleMiceProtein TransportSperm MotilitySpermatozoaConceptsFlagellar membraneFlagellar membrane targetingC2 domain proteinsCatSper channelsCatSper channel complexMammalian sperm cellsSperm hyperactivated motilityMale fertilityMembrane targetingTrafficking machineryDomain proteinsLoss of functionHyperactivated motilitySpatiotemporal CaChannel assemblyMolecular mechanismsSperm cellsChannel complexFlagellaMotilityC2CD6MembraneCalcium channelsMachineryProtein
2019
A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters
Luo T, Chen H, Zou Q, Wang T, Cheng Y, Wang H, Wang F, Jin Z, Chen Y, Weng S, Zeng X. A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters. Human Reproduction 2019, 34: 414-423. PMID: 30629171, DOI: 10.1093/humrep/dey377.Peer-Reviewed Original ResearchConceptsIdiopathic male infertilityNormal semen parametersWhole-cell patch-clamp techniqueMale infertilityPatch-clamp techniqueSemen parametersCatSper currentsIdiopathic infertilitySTUDY FUNDING/COMPETINGGenetic abnormalitiesCatSper genesChild Health HospitalReproductive medical centerNovel copy number variationsPARTICIPANTS/MATERIALSROLE OF CHANCEHuman male infertilityHealthy male donorsCopy number variationsHuman CatSperPrinciple Ca2Progesterone responseCase reportProvincial MaternalHealth Hospital
2016
Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa
Zou Q, Peng Z, Zhao Q, Chen H, Cheng Y, Liu Q, He Y, Weng S, Wang H, Wang T, Zheng L, Luo T. Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa. Human Reproduction 2016, 32: 290-298. PMID: 28031325, DOI: 10.1093/humrep/dew332.Peer-Reviewed Original ResearchConceptsNon-genomic mannerProgesterone actionHuman sperm functionEndocrine-disrupting chemicalsSperm intracellular calcium concentrationsWhole-cell patch-clamp techniqueSperm functionHuman spermatozoaPARTICIPANTS/MATERIALSHuman sperm penetrationIndicator Fluo-4 AMIntracellular calcium concentrationROLE OF CHANCEAcrosome reactionEffects of diethylstilbestrolPatch-clamp techniqueFluo-4 AMFemale reproductive tract fluidsMale reproductive systemTyrosine phosphorylationReproductive tract fluidsDES exposurePostnatal exposureEstrogenic endocrine disruptorsAbility of sperm