2022
RNA methylation in immune cells
Chen Y, Oh M, Flavell R, Li H. RNA methylation in immune cells. Advances In Immunology 2022, 155: 39-94. PMID: 36357012, DOI: 10.1016/bs.ai.2022.08.002.Peer-Reviewed Original Research
2021
m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity
Qin Y, Li B, Arumugam S, Lu Q, Mankash SM, Li J, Sun B, Li J, Flavell RA, Li HB, Ouyang X. m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity. Cell Reports 2021, 37: 109968. PMID: 34758326, PMCID: PMC8667589, DOI: 10.1016/j.celrep.2021.109968.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseProgression of NAFLDLineage-restricted deletionFatty liver diseaseMultiple mRNA transcriptsMyeloid cell activationDiet-induced developmentMethyladenosine (m<sup>6</sup>A) RNA modificationMRNA metabolismProtein methyltransferaseLiver diseaseRNA modificationsCellular stressMetabolic reprogrammingDDIT4 mRNACell activationObesityDifferential expressionMammalian targetMRNA transcriptsSignificant downregulationCytokine stimulationPathway activityMetabolic phenotypeMRNA levels
2020
m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development
Gao Y, Vasic R, Song Y, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA, Li HB, Tebaldi T, Halene S. m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development. Immunity 2020, 52: 1007-1021.e8. PMID: 32497523, PMCID: PMC7408742, DOI: 10.1016/j.immuni.2020.05.003.Peer-Reviewed Original ResearchConceptsDouble-stranded RNADeleterious innate immune responseMammalian hematopoietic developmentEndogenous double-stranded RNAHematopoietic developmentInnate immune responseAbundant RNA modificationMurine fetal liverPattern recognition receptor pathwaysImmune responseProtein codingDsRNA formationRNA modificationsWriter METTL3Hematopoietic defectsPerinatal lethalityNative stateConditional deletionAberrant innate immune responsesLoss of METTL3Hematopoietic failureReceptor pathwayAberrant immune responsePrevents formationFetal liver
2019
hnRNPA2B1: a nuclear DNA sensor in antiviral immunity
Zhang X, Flavell RA, Li HB. hnRNPA2B1: a nuclear DNA sensor in antiviral immunity. Cell Research 2019, 29: 879-880. PMID: 31471560, PMCID: PMC6889404, DOI: 10.1038/s41422-019-0226-8.Peer-Reviewed Original ResearchAntiviral immunity: a link to bile acids
Wang J, Flavell RA, Li HB. Antiviral immunity: a link to bile acids. Cell Research 2019, 29: 177-178. PMID: 30778178, PMCID: PMC6460437, DOI: 10.1038/s41422-019-0148-5.Peer-Reviewed Original Research
2018
cGAS activation in phased droplets
Liu Y, Li HB, Flavell RA. cGAS activation in phased droplets. Cell Research 2018, 28: 967-968. PMID: 30218060, PMCID: PMC6170418, DOI: 10.1038/s41422-018-0087-6.Peer-Reviewed Original Research
2017
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells
Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature 2017, 546: 667-670. PMID: 28636595, PMCID: PMC5787375, DOI: 10.1038/nature22967.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosis Regulatory ProteinsCARD Signaling Adaptor ProteinsCaspase 1DEAD-box RNA HelicasesEpithelial CellsFemaleImmunity, InnateInflammasomesInterleukin-18Intestinal MucosaIntestinesIntracellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLPhosphate-Binding ProteinsPyroptosisReceptors, G-Protein-CoupledRNA, Double-StrandedRotavirusRotavirus Infections
2014
Inflammasome activation and metabolic disease progression
Li HB, Jin C, Chen Y, Flavell RA. Inflammasome activation and metabolic disease progression. Cytokine & Growth Factor Reviews 2014, 25: 699-706. PMID: 25156419, DOI: 10.1016/j.cytogfr.2014.07.020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansImmunity, InnateInflammasomesInterleukin-18Interleukin-1betaMetabolic DiseasesObesityConceptsObesity-associated metabolic diseasesCytokines IL-1βMetabolic stressInnate immune systemMetabolic disease progressionIL-18IL-1βWorldwide epidemicDisease progressionInflammasome activationMetabolic diseasesImmune systemCytosolic sensorsRecent evidenceInflammasomeNLRActivationDifferent tissuesMetabolic systems