Insulators, Not Polycomb Response Elements, Are Required for Long-Range Interactions between Polycomb Targets in Drosophila melanogaster
Li HB, Müller M, Bahechar IA, Kyrchanova O, Ohno K, Georgiev P, Pirrotta V. Insulators, Not Polycomb Response Elements, Are Required for Long-Range Interactions between Polycomb Targets in Drosophila melanogaster. Molecular And Cellular Biology 2011, 31: 616-625. PMID: 21135119, PMCID: PMC3028641, DOI: 10.1128/mcb.00849-10.Peer-Reviewed Original ResearchConceptsPolycomb response elementsPcG targetsPcG complexesResponse elementChromosome conformation capture methodsPolycomb group complexesFab-7 elementHigher-order organizationPolycomb targetsDrosophila melanogasterEnhanced repressionInsulator activityRepressive activityTrans interactionsRegulatory elementsPhysical colocalizationFunctional assaysGroup complexesCapture methodComplexesFluorescence imagingPolycombDrosophilaMelanogasterMajor determinant