2022
m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB–mediated antiapoptotic pathway
Zhang T, Ding C, Chen H, Zhao J, Chen Z, Chen B, Mao K, Hao Y, Roulis M, Xu H, Kluger Y, Zou Q, Ye Y, Zhan M, Flavell RA, Li HB. m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB–mediated antiapoptotic pathway. Science Advances 2022, 8: eabl5723. PMID: 35333576, PMCID: PMC8956260, DOI: 10.1126/sciadv.abl5723.Peer-Reviewed Original ResearchConceptsMucosal barrier dysfunctionInflammatory bowel diseaseBarrier dysfunctionColonic epithelial cellsColonic mucosal barrier dysfunctionEpithelial cellsStem cellsNF-κB pathwayPotential therapeutic targetEpithelial cell deathEpithelial cell homeostasisSevere colitisBowel diseaseColonic stem cellsTherapeutic targetMouse colonStem cell apoptosisDysfunctionMajor causeCell apoptosisImportant modulatorPathological processesAntiapoptotic pathwaysSpecific deletionCell homeostasis
2017
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells
Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature 2017, 546: 667-670. PMID: 28636595, PMCID: PMC5787375, DOI: 10.1038/nature22967.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosis Regulatory ProteinsCARD Signaling Adaptor ProteinsCaspase 1DEAD-box RNA HelicasesEpithelial CellsFemaleImmunity, InnateInflammasomesInterleukin-18Intestinal MucosaIntestinesIntracellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLPhosphate-Binding ProteinsPyroptosisReceptors, G-Protein-CoupledRNA, Double-StrandedRotavirusRotavirus Infections