Insulators Target Active Genes to Transcription Factories and Polycomb-Repressed Genes to Polycomb Bodies
Li HB, Ohno K, Gui H, Pirrotta V. Insulators Target Active Genes to Transcription Factories and Polycomb-Repressed Genes to Polycomb Bodies. PLOS Genetics 2013, 9: e1003436. PMID: 23637616, PMCID: PMC3630138, DOI: 10.1371/journal.pgen.1003436.Peer-Reviewed Original ResearchConceptsPolycomb response elementsPolycomb target genesPolycomb bodiesTranscription factoriesTarget genesSpecialized transcription factoriesAbsence of CTCFInsulator protein CTCFInsulator proteinsPolycomb proteinsPolycomb groupProtein CTCFActive genesChromosomal contextCellular memoryEnhancer specificityGenomic clustersStable associationResponse elementGenesDifferent nuclear structuresTrithoraxCTCFActive stateCritical role