2016
The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury
Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA. The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science 2016, 354: 765-768. PMID: 27846608, PMCID: PMC5640175, DOI: 10.1126/science.aaf7532.Peer-Reviewed Original ResearchConceptsCell deathDNA sensor AIM2New therapeutic targetsCaspase-1-dependent deathIntestinal epithelial cellsBone marrow cellsGastrointestinal syndromeTissue injuryInflammasome activationGastrointestinal tractRadiation-induced cell deathRadiation-induced DNA damageTherapeutic targetAcute exposureBone marrowChemotherapeutic agentsMarrow cellsRadiation exposureAIM2Massive cell deathEpithelial cellsHematopoietic failureDeathMolecular mechanismsDNA damage
2014
Inflammasome activation and metabolic disease progression
Li HB, Jin C, Chen Y, Flavell RA. Inflammasome activation and metabolic disease progression. Cytokine & Growth Factor Reviews 2014, 25: 699-706. PMID: 25156419, DOI: 10.1016/j.cytogfr.2014.07.020.Peer-Reviewed Original ResearchConceptsObesity-associated metabolic diseasesCytokines IL-1βMetabolic stressInnate immune systemMetabolic disease progressionIL-18IL-1βWorldwide epidemicDisease progressionInflammasome activationMetabolic diseasesImmune systemCytosolic sensorsRecent evidenceInflammasomeNLRActivationDifferent tissuesMetabolic systems