2017
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells
Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature 2017, 546: 667-670. PMID: 28636595, PMCID: PMC5787375, DOI: 10.1038/nature22967.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosis Regulatory ProteinsCARD Signaling Adaptor ProteinsCaspase 1DEAD-box RNA HelicasesEpithelial CellsFemaleImmunity, InnateInflammasomesInterleukin-18Intestinal MucosaIntestinesIntracellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLPhosphate-Binding ProteinsPyroptosisReceptors, G-Protein-CoupledRNA, Double-StrandedRotavirusRotavirus Infections
2014
Inflammasome activation and metabolic disease progression
Li HB, Jin C, Chen Y, Flavell RA. Inflammasome activation and metabolic disease progression. Cytokine & Growth Factor Reviews 2014, 25: 699-706. PMID: 25156419, DOI: 10.1016/j.cytogfr.2014.07.020.Peer-Reviewed Original ResearchConceptsObesity-associated metabolic diseasesCytokines IL-1βMetabolic stressInnate immune systemMetabolic disease progressionIL-18IL-1βWorldwide epidemicDisease progressionInflammasome activationMetabolic diseasesImmune systemCytosolic sensorsRecent evidenceInflammasomeNLRActivationDifferent tissuesMetabolic systems