2021
Multiple Functions of RNA Methylation in T Cells: A Review
Chao Y, Li H, Zhou J. Multiple Functions of RNA Methylation in T Cells: A Review. Frontiers In Immunology 2021, 12: 627455. PMID: 33912158, PMCID: PMC8071866, DOI: 10.3389/fimmu.2021.627455.Peer-Reviewed Original ResearchConceptsRNA methylationRNA modificationsMessenger RNAFate determinationEpigenetic regulationEpigenetic modificationsNoncoding RNAsCell homeostasisUbiquitous mechanismMethylationBiological significanceT cell homeostasisMultiple functionsCell proliferationEssential rolePotential therapeutic strategyRecent findingsRNAImmune responseBiological activityPathological statesT cellsCellsTherapeutic strategiesViral infection
2019
Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells
Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B, Liu J, Zou Q. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metabolism 2019, 30: 290-302.e5. PMID: 31204281, DOI: 10.1016/j.cmet.2019.05.016.Peer-Reviewed Original ResearchConceptsAcylglycerol kinasePhosphatidylinositol-3-OH kinasePTEN phosphatase activityRecruitment of PTENCell glycolytic metabolismCell antigen receptorPTEN activityPlasma membranePTEN phosphorylationKinase activityRapamycin (mTOR) signalingMammalian targetPhosphatase activityCell glycolysisCell expansionGlycolytic metabolismCell proliferationMetabolic programmingMetabolic stateAntigen receptorKinaseCritical roleGlycolysisCellsFunctional state