2024
Repurposing non-pharmacological interventions for Alzheimer's disease through link prediction on biomedical literature
Xiao Y, Hou Y, Zhou H, Diallo G, Fiszman M, Wolfson J, Zhou L, Kilicoglu H, Chen Y, Su C, Xu H, Mantyh W, Zhang R. Repurposing non-pharmacological interventions for Alzheimer's disease through link prediction on biomedical literature. Scientific Reports 2024, 14: 8693. PMID: 38622164, PMCID: PMC11018822, DOI: 10.1038/s41598-024-58604-8.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseManual therapy techniquesR-GCNKnowledge graphAD preventionNon-pharmacological interventionsBiomedical literatureGraph convolutional network modelKG embedding modelsTest setLink prediction modelIntegrated healthConvolutional network modelImprove cognitive functionHighest scoring candidatesDomain expertsEmbedding modelNon-pharmaceutical interventionsReal-world data analysisGround truthPrevent ADCognitive functionTherapy techniquesNetwork modelDiscovery patterns
2015
A study of active learning methods for named entity recognition in clinical text
Chen Y, Lasko T, Mei Q, Denny J, Xu H. A study of active learning methods for named entity recognition in clinical text. Journal Of Biomedical Informatics 2015, 58: 11-18. PMID: 26385377, PMCID: PMC4934373, DOI: 10.1016/j.jbi.2015.09.010.Peer-Reviewed Original ResearchConceptsClinical NER tasksMachine learningAnnotation costF-measureEntity recognitionNER taskActive learningLearning methodsI2b2/VA NLP challengeNatural language processing systemsPerformance of MLClinical natural language processing (NLP) systemsSequential labeling tasksSupervised machine learningAL methodsLanguage processing systemDiversity-based methodReal-time settingActive learning methodsNew AL methodsNER corpusDomain expertsUncertainty samplingAnnotation effortClinical text