2023
The All of Us Data and Research Center: Creating a Secure, Scalable, and Sustainable Ecosystem for Biomedical Research
Mayo K, Basford M, Carroll R, Dillon M, Fullen H, Leung J, Master H, Rura S, Sulieman L, Kennedy N, Banks E, Bernick D, Gauchan A, Lichtenstein L, Mapes B, Marginean K, Nyemba S, Ramirez A, Rotundo C, Wolfe K, Xia W, Azuine R, Cronin R, Denny J, Kho A, Lunt C, Malin B, Natarajan K, Wilkins C, Xu H, Hripcsak G, Roden D, Philippakis A, Glazer D, Harris P. The All of Us Data and Research Center: Creating a Secure, Scalable, and Sustainable Ecosystem for Biomedical Research. Annual Review Of Biomedical Data Science 2023, 6: 443-464. PMID: 37561600, PMCID: PMC11157478, DOI: 10.1146/annurev-biodatasci-122120-104825.Peer-Reviewed Original Research
2017
CATTLE (CAncer treatment treasury with linked evidence): An integrated knowledge base for personalized oncology research and practice
Soysal E, Lee H, Zhang Y, Huang L, Chen X, Wei Q, Zheng W, Chang J, Cohen T, Sun J, Xu H. CATTLE (CAncer treatment treasury with linked evidence): An integrated knowledge base for personalized oncology research and practice. CPT Pharmacometrics & Systems Pharmacology 2017, 6: 188-196. PMID: 28296354, PMCID: PMC5351410, DOI: 10.1002/psp4.12174.Peer-Reviewed Original Research
2016
Automated identification of molecular effects of drugs (AIMED)
Fathiamini S, Johnson A, Zeng J, Araya A, Holla V, Bailey A, Litzenburger B, Sanchez N, Khotskaya Y, Xu H, Meric-Bernstam F, Bernstam E, Cohen T. Automated identification of molecular effects of drugs (AIMED). Journal Of The American Medical Informatics Association 2016, 23: 758-765. PMID: 27107438, PMCID: PMC4926748, DOI: 10.1093/jamia/ocw030.Peer-Reviewed Original ResearchExtracting genetic alteration information for personalized cancer therapy from ClinicalTrials.gov
Xu J, Lee H, Zeng J, Wu Y, Zhang Y, Huang L, Johnson A, Holla V, Bailey A, Cohen T, Meric-Bernstam F, Bernstam E, Xu H. Extracting genetic alteration information for personalized cancer therapy from ClinicalTrials.gov. Journal Of The American Medical Informatics Association 2016, 23: 750-757. PMID: 27013523, PMCID: PMC4926744, DOI: 10.1093/jamia/ocw009.Peer-Reviewed Original ResearchConceptsCancer treatment trials
2015
Education, collaboration, and innovation: intelligent biology and medicine in the era of big data
Ruan J, Jin V, Huang Y, Xu H, Edwards J, Chen Y, Zhao Z. Education, collaboration, and innovation: intelligent biology and medicine in the era of big data. BMC Genomics 2015, 16: s1. PMID: 26099197, PMCID: PMC4474420, DOI: 10.1186/1471-2164-16-s7-s1.Peer-Reviewed Original Research
2011
Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin
Xu H, Jiang M, Oetjens M, Bowton E, Ramirez A, Jeff J, Basford M, Pulley J, Cowan J, Wang X, Ritchie M, Masys D, Roden D, Crawford D, Denny J. Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin. Journal Of The American Medical Informatics Association 2011, 18: 387-391. PMID: 21672908, PMCID: PMC3128409, DOI: 10.1136/amiajnl-2011-000208.Peer-Reviewed Original ResearchAlgorithmsAnticoagulantsAryl Hydrocarbon HydroxylasesCytochrome P-450 CYP2C9Data MiningDatabases, Nucleic AcidDrug Dosage CalculationsElectronic Health RecordsGenome-Wide Association StudyHumansLinear ModelsMixed Function OxygenasesNatural Language ProcessingPharmacogeneticsPrecision MedicineUnited StatesVitamin K Epoxide ReductasesWarfarin