2021
Comprehensive Characterization of COVID-19 Patients with Repeatedly Positive SARS-CoV-2 Tests Using a Large U.S. Electronic Health Record Database
Dong X, Zhou Y, Shu X, Bernstam E, Stern R, Aronoff D, Xu H, Lipworth L. Comprehensive Characterization of COVID-19 Patients with Repeatedly Positive SARS-CoV-2 Tests Using a Large U.S. Electronic Health Record Database. Microbiology Spectrum 2021, 9: 10.1128/spectrum.00327-21. PMID: 34406805, PMCID: PMC8552669, DOI: 10.1128/spectrum.00327-21.Peer-Reviewed Original ResearchConceptsPositive SARS-CoV-2 testSARS-CoV-2 testSecond positive testElectronic health record databaseCases of reinfectionHealth record databasePositive testPositive SARS-CoV-2 PCR test resultsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testingSARS-CoV-2 PCR test resultsRecord databaseSevere acute respiratory syndrome coronavirus 2Intensive care unit admissionAcute respiratory syndrome coronavirus 2SARS-CoV-2 infectionRespiratory syndrome coronavirus 2Long-term health consequencesLarge electronic health record databasePotential long-term health consequencesCare unit admissionOverweight/obeseChronic medical conditionsPositive molecular testCOVID-19 patientsSyndrome coronavirus 2Leveraging a health information exchange for analyses of COVID-19 outcomes including an example application using smoking history and mortality
Tortolero G, Brown M, Sharma S, de Oliveira Otto M, Yamal J, Aguilar D, Gunther M, Mofleh D, Harris R, John J, de Vries P, Ramphul R, Serbo D, Kiger J, Banerjee D, Bonvino N, Merchant A, Clifford W, Mikhail J, Xu H, Murphy R, Wei Q, Vahidy F, Morrison A, Boerwinkle E. Leveraging a health information exchange for analyses of COVID-19 outcomes including an example application using smoking history and mortality. PLOS ONE 2021, 16: e0247235. PMID: 34081724, PMCID: PMC8174716, DOI: 10.1371/journal.pone.0247235.Peer-Reviewed Original ResearchConceptsBody mass indexCOVID-19 patientsRisk factorsTobacco useCOVID-19 fatalitiesHealth information exchangeRace/ethnicityCOVID-19Laboratory risk factorsNumber of comorbiditiesCOVID-19 cohortMultivariable logistic regressionImportant risk factorPotential risk factorsCOVID-19 outcomesFormer tobacco usersTobacco use historyLarge health information exchangeMass indexElectronic health record systemsUnfavorable outcomeClinical dataTobacco usersOutcome analysisElectronic health information
2020
Asthma Exacerbation Prediction and Risk Factor Analysis Based on a Time-Sensitive, Attentive Neural Network: Retrospective Cohort Study
Xiang Y, Ji H, Zhou Y, Li F, Du J, Rasmy L, Wu S, Zheng W, Xu H, Zhi D, Zhang Y, Tao C. Asthma Exacerbation Prediction and Risk Factor Analysis Based on a Time-Sensitive, Attentive Neural Network: Retrospective Cohort Study. Journal Of Medical Internet Research 2020, 22: e16981. PMID: 32735224, PMCID: PMC7428917, DOI: 10.2196/16981.Peer-Reviewed Original ResearchConceptsAttentive Neural NetworkAsthma exacerbationsRisk factorsNeural networkAdvanced deep learning modelsClinical variablesDeep learning modelsCerner Health Facts databaseLarge electronic health recordNeural network modelRetrospective cohort studyHealth Facts databasePotential risk factorsRisk factor analysisPersonalized risk factorsElectronic health recordsBaseline methodsLearning modelPersonalized risk scoreProgressive asthmaAsthma symptomsEsophageal refluxAdult patientsCohort studyTime-Sensitive
2019
Analysis on geographic variations in hospital deaths and endovascular therapy in ischaemic stroke patients: an observational cross-sectional study in China
Chen H, Shi L, Wang N, Han Y, Lin Y, Dai M, Liu H, Dong X, Xue M, Xu H. Analysis on geographic variations in hospital deaths and endovascular therapy in ischaemic stroke patients: an observational cross-sectional study in China. BMJ Open 2019, 9: e029079. PMID: 31239305, PMCID: PMC6597735, DOI: 10.1136/bmjopen-2019-029079.Peer-Reviewed Original ResearchConceptsObservational cross-sectional studyIschemic stroke patientsCross-sectional studyEVT useHospital mortalityTertiary hospitalStroke patientsEmergency departmentAssociated potential risk factorsNationwide hospital discharge databaseEndovascular therapy useHigher hospital mortalityHospital mortality rateHospital discharge databaseHospital discharge dataPost-stroke outcomesChina's tertiary hospitalsPotential risk factorsCause of deathNational Health CommissionHospital deathHospitalised patientsOlder patientsEndovascular therapyMale patientsExploring temporal suicidal behavior patterns on social media: Insight from Twitter analytics
Luo J, Du J, Tao C, Xu H, Zhang Y. Exploring temporal suicidal behavior patterns on social media: Insight from Twitter analytics. Health Informatics Journal 2019, 26: 738-752. PMID: 30866708, DOI: 10.1177/1460458219832043.Peer-Reviewed Original ResearchConceptsRisk factorsDifferent risk factorsPotential suicidal ideationPublic health servicesKey risk factorsSuicide-related tweetsPrevention strategiesHealth servicesSuicidal ideationSuicide behaviorSuicide detectionSuicide ratesDifferent daysWider populationTemporal patternsBehavior patternsPopulationFactorsWeeks
2018
Psychiatric stressor recognition from clinical notes to reveal association with suicide
Zhang Y, Zhang O, Li R, Flores A, Selek S, Zhang X, Xu H. Psychiatric stressor recognition from clinical notes to reveal association with suicide. Health Informatics Journal 2018, 25: 1846-1862. PMID: 30328378, DOI: 10.1177/1460458218796598.Peer-Reviewed Original ResearchConceptsElectronic health recordsSuicidal behaviorHealth recordsSuicide ideation/attemptsTremendous economic burdenPsychiatric stressorsSuicide risk factorsRisk factorsEconomic burdenPsychiatric stressClinical notesLarge-scale studiesPsychiatric notesSuicideAssociationSignificant stressorsStressorsPrior studiesPercentPrevious studiesStudy
2014
Genotype and risk of major bleeding during warfarin treatment
Kawai V, Cunningham A, Vear S, Van Driest S, Oginni A, Xu H, Jiang M, Li C, Denny J, Shaffer C, Bowton E, Gage B, Ray W, Roden D, Stein C. Genotype and risk of major bleeding during warfarin treatment. Pharmacogenomics 2014, 15: 1973-1983. PMID: 25521356, PMCID: PMC4304738, DOI: 10.2217/pgs.14.153.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiological Specimen BanksCytochrome P-450 CYP2C9Cytochrome P-450 Enzyme SystemCytochrome P450 Family 4Dose-Response Relationship, DrugEthnicityFemaleGene FrequencyGenetic Association StudiesGenetic VariationGenotypeHemorrhageHumansMaleMiddle AgedRisk FactorsVitamin K Epoxide ReductasesWarfarin
2004
Facilitating cancer research using natural language processing of pathology reports.
Xu H, Anderson K, Grann V, Friedman C. Facilitating cancer research using natural language processing of pathology reports. 2004, 107: 565-72. PMID: 15360876.Peer-Reviewed Original Research