2012
Predicting warfarin dosage in EuropeanAmericans and AfricanAmericans using DNA samples linked to an electronic health record
Ramirez A, Shi Y, Schildcrout J, Delaney J, Xu H, Oetjens M, Zuvich R, Basford M, Bowton E, Jiang M, Speltz P, Zink R, Cowan J, Pulley J, Ritchie M, Masys D, Roden D, Crawford D, Denny J. Predicting warfarin dosage in EuropeanAmericans and AfricanAmericans using DNA samples linked to an electronic health record. Pharmacogenomics 2012, 13: 407-418. PMID: 22329724, PMCID: PMC3361510, DOI: 10.2217/pgs.11.164.Peer-Reviewed Original ResearchAdultAgedAged, 80 and overAnticoagulantsAryl Hydrocarbon HydroxylasesBlack or African AmericanCalcium-Binding ProteinsCytochrome P-450 CYP2C9Cytochrome P-450 Enzyme SystemCytochrome P450 Family 4Dose-Response Relationship, DrugDrug Administration ScheduleElectronic Health RecordsFemaleHumansMaleMiddle AgedMixed Function OxygenasesPolymorphism, Single NucleotideSubstance-Related DisordersVitamin K Epoxide ReductasesWarfarinWhite People
2011
Predicting Clopidogrel Response Using DNA Samples Linked to an Electronic Health Record
Delaney J, Ramirez A, Bowton E, Pulley J, Basford M, Schildcrout J, Shi Y, Zink R, Oetjens M, Xu H, Cleator J, Jahangir E, Ritchie M, Masys D, Roden D, Crawford D, Denny J. Predicting Clopidogrel Response Using DNA Samples Linked to an Electronic Health Record. Clinical Pharmacology & Therapeutics 2011, 91: 257-263. PMID: 22190063, PMCID: PMC3621954, DOI: 10.1038/clpt.2011.221.Peer-Reviewed Original ResearchMeSH KeywordsAgedAryl Hydrocarbon HydroxylasesAryldialkylphosphataseATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1ClopidogrelCytochrome P-450 CYP2C19Databases, Nucleic AcidElectronic Health RecordsFemaleGenotypeHumansMaleMyocardial InfarctionPharmacogeneticsPlatelet Aggregation InhibitorsPolymorphism, GeneticStentsThrombosisTiclopidineTreatment OutcomeConceptsPercutaneous coronary interventionElectronic health recordsCardiac eventsMyocardial infarctionRecurrent cardiac eventsRecurrent cardiovascular eventsHealth recordsUse of EHRsClopidogrel therapyCardiovascular eventsClopidogrel treatmentClopidogrel resistanceClopidogrel responseCoronary interventionStent thrombosisReal-world settingCYP2C19ABCB1PON1Pharmacogenomic studiesRecurrent eventsTreatmentDNA repositoryDNA samplesInfarctionFacilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin
Xu H, Jiang M, Oetjens M, Bowton E, Ramirez A, Jeff J, Basford M, Pulley J, Cowan J, Wang X, Ritchie M, Masys D, Roden D, Crawford D, Denny J. Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin. Journal Of The American Medical Informatics Association 2011, 18: 387-391. PMID: 21672908, PMCID: PMC3128409, DOI: 10.1136/amiajnl-2011-000208.Peer-Reviewed Original ResearchAlgorithmsAnticoagulantsAryl Hydrocarbon HydroxylasesCytochrome P-450 CYP2C9Data MiningDatabases, Nucleic AcidDrug Dosage CalculationsElectronic Health RecordsGenome-Wide Association StudyHumansLinear ModelsMixed Function OxygenasesNatural Language ProcessingPharmacogeneticsPrecision MedicineUnited StatesVitamin K Epoxide ReductasesWarfarin