2020
COVID-19 TestNorm: A tool to normalize COVID-19 testing names to LOINC codes
Dong X, Li J, Soysal E, Bian J, DuVall S, Hanchrow E, Liu H, Lynch K, Matheny M, Natarajan K, Ohno-Machado L, Pakhomov S, Reeves R, Sitapati A, Abhyankar S, Cullen T, Deckard J, Jiang X, Murphy R, Xu H. COVID-19 TestNorm: A tool to normalize COVID-19 testing names to LOINC codes. Journal Of The American Medical Informatics Association 2020, 27: 1437-1442. PMID: 32569358, PMCID: PMC7337837, DOI: 10.1093/jamia/ocaa145.Peer-Reviewed Original ResearchConceptsElectronic health recordsLOINC codesSecondary useRule-based toolOnline web applicationOpen-source packageCritical data elementsWeb applicationData networksEnd usersData elementsIndependent test setHealth recordsTest setKey challengesData normalizationCritical resourcesTest namesRoutine clinical practice dataCodeClinical practice dataCoronavirus disease 2019COVID-19 diagnostic testsToolDevelopersEfficient and Accurate Extracting of Unstructured EHRs on Cancer Therapy Responses for the Development of RECIST Natural Language Processing Tools: Part I, the Corpus
Li Y, Luo Y, Wampfler J, Rubinstein S, Tiryaki F, Ashok K, Warner J, Xu H, Yang P. Efficient and Accurate Extracting of Unstructured EHRs on Cancer Therapy Responses for the Development of RECIST Natural Language Processing Tools: Part I, the Corpus. JCO Clinical Cancer Informatics 2020, 4: cci.19.00147. PMID: 32364754, PMCID: PMC7265793, DOI: 10.1200/cci.19.00147.Peer-Reviewed Original ResearchConceptsNatural language processing toolsElectronic health recordsLanguage processing toolsGold standard dataUnstructured electronic health recordsProcessing toolsAmount of dataClinical notesStandard dataMayo Clinic electronic health recordsClinic's electronic health recordEnvironment toolsAccurate annotationHealth recordsInformatics toolsEffective analysisData setsTextual sourcesCorpusToolInformationData extractionSetExtractingAnnotation
2017
Lightweight predicate extraction for patient-level cancer information and ontology development
Amith M, Song H, Zhang Y, Xu H, Tao C. Lightweight predicate extraction for patient-level cancer information and ontology development. BMC Medical Informatics And Decision Making 2017, 17: 73. PMID: 28699547, PMCID: PMC5506564, DOI: 10.1186/s12911-017-0465-x.Peer-Reviewed Original ResearchConceptsOntological knowledgebaseKnowledge triplesInformation extraction toolsDevelopment of ontologiesNatural language domainRDF representationSoftware libraryOntology developmentCustom applicationsOntologyDevelopment processExtraction toolAccurate extractionPublic health domainKnowledgebaseTextual sourcesTriplesKnowledgebasesHealth domainsToolExtractionTaskMethodsThis paperMedlinePlusDomainExpressing Biomedical Ontologies in Natural Language for Expert Evaluation.
Amith M, Manion F, Harris M, Zhang Y, Xu H, Tao C. Expressing Biomedical Ontologies in Natural Language for Expert Evaluation. 2017, 245: 838-842. PMID: 29295217, PMCID: PMC6644701.Peer-Reviewed Original Research
2014
Chapter 12 Linking Genomic and Clinical Data for Discovery and Personalized Care
Denny J, Xu H. Chapter 12 Linking Genomic and Clinical Data for Discovery and Personalized Care. 2014, 395-424. DOI: 10.1016/b978-0-12-401678-1.00012-9.Peer-Reviewed Original ResearchElectronic health recordsEHR dataNatural language processingSuch algorithmsLanguage processingDecision supportPhenotype algorithmsIdeal repositoryHealth recordsNumber of challengesRepositoryAlgorithmClinical notesClinical careClinical documentationGenomic dataResult dataAccurate caseDNA biobanksEarly demonstration projectsHealth care qualityClinical recordsMedication recordsClinical dataTool
2012
DTome: a web-based tool for drug-target interactome construction
Sun J, Wu Y, Xu H, Zhao Z. DTome: a web-based tool for drug-target interactome construction. BMC Bioinformatics 2012, 13: s7. PMID: 22901092, PMCID: PMC3372450, DOI: 10.1186/1471-2105-13-s9-s7.Peer-Reviewed Original ResearchConceptsWeb-based toolUser-friendly web interfaceWeb-based queriesRich data sourceDifferent knowledge basesDatabase schemaWeb interfaceVisualization processKnowledge basesComputational workflowDiscovery processData sourcesNetworkDrug-target interactionsDrugs' primary targetsDrug-target networkWorkflowEarly-stage drug discoveryNetwork analysisQueriesToolPromising approachDrug discovery processSchemaDetailed network analysis
2006
A natural language processing (NLP) tool to assist in the curation of the laboratory Mouse Tumor Biology Database.
Xu H, Krupke D, Blake J, Friedman C. A natural language processing (NLP) tool to assist in the curation of the laboratory Mouse Tumor Biology Database. AMIA Annual Symposium Proceedings 2006, 2006: 1150. PMID: 17238769, PMCID: PMC1839428.Peer-Reviewed Original ResearchConceptsMouse Genome Informatics groupNatural language processing toolsModel organism databaseMouse Tumor Biology DatabaseLanguage processing toolsBiology databasesOrganism databasesGenomic informationBiological communitiesProcessing toolsSpecific organismsInformatics GroupOrganismsKey informationDatabaseInformationSubstantial effortCurationTool